Results 91 to 100 of about 22,988 (314)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

General Relativity and the AKSZ Construction. [PDF]

Commun Math Phys, 2021
Canepa G, Cattaneo AS, Schiavina M.
europepmc   +1 more source

Testing general relativity with geodetic VLBI [PDF]

, 2018
Oleg Titov, Anastasiia Girdiuk, S. B. Lambert, J. E. J. Lovell, Lucia McCallum, Stanislav S. Shabala, Lucia McCallum, David J. Mayer, Matthias Schartner, Aletha de Witt, Fengchun Shu, Alexey Melnikov, Д. В. Иванов, A. G. Mikhailov, Shaohua Yi, Benedikt Soja, Bo Xia, Tianyu Jiang   +17 more
openalex   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Towards Unification of General Relativity and Quantum Theory: Dendrogram Representation of the Event-Universe. [PDF]

Entropy (Basel), 2022
Shor O, Benninger F, Khrennikov A.
europepmc   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Quantum vacuum energy in general relativity

European Physical Journal C: Particles and Fields, 2018
The paper deals with the scale discrepancy between the observed vacuum energy in cosmology and the theoretical quantum vacuum energy (cosmological constant problem).
Christian Henke
doaj   +1 more source

Geometry of static w = - 1 / 5 perfect fluid spheres in general relativity. [PDF]

Eur Phys J C Part Fields, 2022
Fazlpour B, Banijamali A, Faraoni V.
europepmc   +1 more source

On an integral formula on hypersurfaces in general relativity [PDF]

, 1997
Jörg Frauendiener, Jörg Frauendiener
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source