Results 101 to 110 of about 6,607,101 (361)
Zagadnienia Filozoficzne w Nauce, 2018 Black holes entered scientific literature as early as at the end of eighteenth century. They had been known at that time as dark stars, but their concept did not find its way to physics or astronomy, and had been abandoned for more than one hundred years.
Edward Malec
doaj
General relativity: An erfc metric
Results in Physics, 2018 This paper proposes an erfc potential to incorporate in a symmetric metric. One key feature of this model is that it relies on the existence of an intrinsic physical constant σ, a star-specific proper length that scales all its surroundings.
Réjean Plamondon
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Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Testing general relativity on accelerators
Physics Letters B, 2015 Within the general theory of relativity, the curvature of spacetime is related to the energy and momentum of the present matter and radiation. One of the more specific predictions of general relativity is the deflection of light and particle trajectories
Tigran Kalaydzhyan
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
A Novel Logarithmic Approach to General Relativistic Hydrodynamics in Dynamical Spacetimes
UniverseWe introduce a novel logarithmic approach within the Baumgarte–Shapiro–Shibata–Nakamura (BSSN) formalism for self-consistently solving the equations of general relativistic hydrodynamics (GRHD) in evolving curved spacetimes. This method employs a “3 + 1”
Mario Imbrogno +3 more
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Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
General Relativity by Kawaguchi geometry
EPJ Web of Conferences, 2013 We construct a parameterisation invariant Lagrange theory of fields up to second order by using multivector bundles and Kawaguchi geometry. In this setup, the spacetime is an dynamical object which is a submanifold of the greater manifold, and the actual
Tanaka Erico
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source