Results 181 to 190 of about 7,004,183 (346)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Numerical Hydrodynamics in General Relativity

open access: yesLiving Reviews in Relativity, 2000
The current status of numerical solutions for the equations of ideal general relativistic hydrodynamics is reviewed. Different formulations of the equations are presented, with special mention of conservative and hyperbolic formulations well-adapted to ...
Font José A.
doaj  

Spacetime Emergence: An (In)effective Story

open access: yesPhilosophy of Physics
Physicists and philosophers are increasingly prone to regarding our current physical theories as providing ‘effective descriptions’ of real-world systems.
Mike D. Schneider
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Black hole thermodynamics: Beyond general relativity

open access: yes, 2013
The striking similarity of the laws of black hole mechanics with thermodynamics was first established in the case of general relativity (GR). But the Einstein-Hilbert Lagrangian of general relativity is only the lowest order term in a derivative ...
Sarkar, Sudipta
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

Some Thoughts on Relativity and the Flow of Time: Einstein's Equations given Absolute Simultaneity [PDF]

open access: yes, 2004
The A-theory of time has intuitive and metaphysical appeal, but suffers from tension, if not inconsistency, with the special and general theories of relativity (STR and GTR).
Pitts, J. Brian
core  

A radiating star in Einstein-Gauss-Bonnet gravity

open access: yesNuclear Physics B
We generate a radiating star in Einstein-Gauss-Bonnet (EGB) gravity for spacetime dimension N=5 and a shear-free geometry. The temporal boundary condition contains curvature corrections from the Lovelock tensor and reduces to the general relativity limit.
Sunil D. Maharaj   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

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