Results 91 to 100 of about 2,435,192 (345)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Emergency General Surgery and Mental Health in the COVID‐19 Syndemic: In Search of the Double‐Edged Blade [PDF]

, 2023
Robert K. Goldman, Jesse R. Fann
openalex   +1 more source

News in Brief [PDF]

, 2011
Gurjyot Bajwa, MD, has joined the Division of Cardiothoracic Surgery. She is fellowship-trained in Adult Cardiac Surgery, Congenital Cardiac Surgery and General Thoracic Surgery.

core   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Cellular Heterogeneity and IL-17 Pathway Dynamics Reveal Insights into the Transition from Ulcerative Colitis to Colorectal Cancer Through scRNA-Seq Analysis

Journal of Inflammation Research
Yaxian Li,1,* Ruochuan Sun,1,* Xiaodong Wang,2 Mengdi Ma,1 Huizhen Wang,1 Bo Yang,1 Yida Lu,3 Yongxiang Li1 1Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2The ...
Li Y, Sun R, Wang X, Ma M, Wang H, Yang B, Lu Y, Li Y   +7 more
doaj  

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

miR-424 Targets AKT3 and PSAT1 and Has a Tumor-Suppressive Role in Human Colorectal Cancer [Retraction]

Cancer Management and Research
Fang Y, Liang X, Xu J, Cai X. Cancer Manag Res. 2018;10:6537–6547. We, the Editors and Publisher of the journal Cancer Management and Research, have retracted the published article.
Fang Y, Liang X, Xu J, Cai X
doaj  

Palliative Surgery in General Surgery Clinics

Bezmiâlem Science, 2022
Adem AKÇAKAYA
doaj   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source

ROS-Responsive Nanosystem Targeted Co-Delivery YC-1 and Regorafenib to Alleviate Hypoxia Enhancing Hepatocellular Carcinoma Therapy

International Journal of Nanomedicine
Liming Song,1– 3 Yahui Wu,1– 3 Senfeng Zhao,1– 3 Yin Liu,1– 3 Zhipu Liu,1– 3 Yunpeng Zhai,1– 3 Jiahui Cao,1– 3 Yaning Xia,4 Ruopeng Liang,1– 3 Weijie Wang,1– 3 Rongtao Zhu,1– 3 Binghua Sun,5 Yupeng Shi,4 Yuling Sun1– 3 1Department of Hepatobiliary and ...
Song L, Wu Y, Zhao S, Liu Y, Liu Z, Zhai Y, Cao J, Xia Y, Liang R, Wang W, Zhu R, Sun B, Shi Y, Sun Y   +13 more
doaj