Results 91 to 100 of about 1,541,462 (314)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Advanced Bariatric and Metabolic Surgery [PDF]

open access: yes, 2012
Bariatric surgery has gained importance in the last 20 years because of the high prevalence of global obesity, and the vast understating of the physiological and pathological aspects of obesity and associated metabolic syndromes.

core   +1 more source

Who should perform thyroid surgery and who should not?

open access: yesTurkish Archives of Otorhinolaryngology, 2007
This report was prepared to • clarify the markedly increased disputes between the General Surgery Departments and Otorhinolaryngology-Head and Neck Surgery (ORL-HNS) Departments in respect to thyroid surgery, • to discuss the subject in question in ...
Levent Erişen   +2 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Screening for negative emotions and analysis of related factors among general surgery inpatients: a retrospective cross-sectional study

open access: yesFrontiers in Psychology
BackgroundAdverse psychological states in surgical patients can impact outcomes. This study aimed to evaluate mood disorders and associated factors in general surgery inpatients using the Huaxi Emotional Distress Index (HEI).MethodsThis retrospective ...
Jie Yang   +10 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Using Mesh Cutting in an Interactive Podiatric Orthopaedic Surgery Simulator [PDF]

open access: yes
Serious games are an established pedagogical tool, with applications in a wide variety of fields. Although this includes the area of medical training, there is currently no podiatric orthopaedic training simulator.
Boothroyd, Andrew
core  

Change in bowel habit, abdominal pain, and a palpable abdominal mass in a 58‐year‐old female

open access: yesClinical Case Reports, 2017
Key Clinical Message Giant colonic diverticulum is a rare complication of diverticulosis, which may present in the acute or chronic setting. Colonic resection and en bloc resection of the diverticulum are the favored management, however, conservative ...
Julian Peacock, Zane Perkins
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Mechanisms and Nanomedicine Interventions of Acute Lung Injury Induced by Intestinal Ischemia-Reperfusion: A Mini Review

open access: yesInternational Journal of Nanomedicine
Guangyao Li,1– 3,* Binghui Jin,3,* Jialin Zhou,3,* Tao Sun,1 Shuang Wang,4 Zhe Fan2,3 1Department of Oncology, Cancer Hospital of Dalian University of Technology, Shenyang, People’s Republic of China; 2Department of General ...
Li G   +5 more
doaj  

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