Results 61 to 70 of about 2,446,651 (342)

Applications of controlled surgery in dimension 4: Examples

, 2006
The validity of Freedman's disk theorem is known to depend only on the fundamental group. It was conjectured that it fails for nonabelian free fundamental groups. If this were true then surgery theory would work in dimension four.
Hegenbarth, Friedrich, Repovš, Dušan
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Distribution of RET proto‐oncogene variants in children with appendicitis

Molecular Genetics & Genomic Medicine, 2022
Background In addition to patient‐related systemic factors directing the immune response, the pathomechanisms of appendicitis (AP) might also include insufficient drainage leading to inflammation caused by decreased peristalsis.
Jurek Schultz, Ines Freibothe, Michael Haase, Patrick Glatte, Gustavo Barreton, Andreas Ziegler, Heike Görgens, Guido Fitze   +7 more
doaj   +1 more source

Frequency of Predisposing Factor of Nausea and Vomiting After Chest Surgery Under General Anaesthesia [PDF]

, 2019
Background: Postoperative nausea and vomiting are common and distressing postsurgical symptoms. These symptoms are of particular concern in outpatient surgery because they may require additional direct resources, such as supplies and antiemetic ...
Bhatti, S. U. (Sami), Hanif, A. (Asif), Rehman, U. A. (Usman), Shahnawaz, A. (Ayesha), Ulhaq, Z. (Zabinfat), Ullah, Q. (Qudrat)   +5 more
core   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Roscoe Reid Graham (1890 to 1948): a Canadian pioneer in general surgery. [PDF]

, 2014
Roscoe Reid Graham, a Canadian surgeon trained at the University of Toronto, was a true pioneer in the field of general surgery. Although he may be best known for his omental patch repair of perforated duodenal ulcers-often referred to as the Graham ...
Cowan, MD, Scott W., Piper, BA, Christine C., Yeo, MD, Charles J.   +2 more
core   +1 more source

Possible Skull Base Erosion After Prolonged Frontal Sinus Stenting [PDF]

, 2019
Frontal sinus stenting is widely used with the goal of maintaining nasofrontal duct patency after sinus surgery. The general recommendation is to leave stents in place for 6 months; however, prolonged stenting up to 6 years has been reported with no ...
Ching, Harry H., MD, Kim, Yuna, MD, Reeve, Nathaniel H., MD, Schroeder, Walter W., MD   +3 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Stress-Induced Hyperglycemia in General Surgery: a Narrative-Review

Novelty in Biomedicine
Background: Stress-induced hyperglycemia, also known as stress hyperglycemia, occurs after severe stress on the body, such as surgery. Awareness of this condition and its management are essential to reducing complications and mortality in patients after ...
Sina Homaee, Farnaz Saberian, Mohammad Mehdi Atarod, Sahar Kavan   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source