Results 71 to 80 of about 2,446,651 (342)
THRIVE In Elderly Patients Undergoing Esophageal Foreign Body Removal Surgery Under General Anesthesia: A Case Series [PDF]
, 2023 Binbin He +59 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Annals of Surgery Open, 2022 Esha Pai, MBBS, MS (General Surgery), MCh. (Surgical Oncology), MRCS +1 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
, 2016 Matthew P. Jenkins, MD, has joined the Division of Plastic Surgery. Dr. Jenkins completed his general surgery residency at Temple University Hospital in 2013 and remained there for fellowship training in Plastic and Reconstructive Surgery.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A Brief Overview of the Life and Work of Lyon Henry Appleby, M.D. (1895-1970). [PDF]
, 2016 The life and work of Dr. Lyon Henry Appleby, M.D., portrays the essence of a devoted clinician committed to scholarly excellence. Born in Deseronto, Ontario, in 1895 and passing in 1970, Dr.
Cowan, Scott W. +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The applications of sub-Tenon's anaesthesia for canine ophthalmic surgery : a thesis presented in fulfilment of the requirements for the degree of Master of Veterinary Science (MVSc) at Massey University, Manawatu, New Zealand [PDF]
, 2016 Sub-Tenon's anaesthesia is an indispensable anaesthetic technique in human ophthalmic surgery. It produces highly effective regional anaesthesia and has a significantly lower complication rate than the previously used peribulbar and retrobulbar ...
Bayley, Kellam David
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source