Results 121 to 130 of about 10,527,177 (301)

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Cost‐effectiveness analysis of a biopsy‐free diagnostic strategy for prostate cancer using mpMRI and PSMA‐PET/CT

BJUI Compass
Introduction Prostate‐Specific Membrane Antigen Positron Emission Tomography Computed Tomography (PSMA PET/CT) has shown a higher diagnostic accuracy in prostate cancer imaging when compared to conventional modalities, with improved sensitivity and ...
Joshua Yi Min Tung, Rachel Shu‐En Lau, Edmund Pek Siang Teo, Kit Mun Chow, Julene Hui Wun Ong, Timothy Siliang Lu, Weiren Chen, Jingqiu Li, Xinyan Yang, Alvin Yuanming Lee, Yu Guang Tan, Kae Jack Tay, Sue Ping Thang, Winnie Wing Chuen Lam, Yan Mee Law, Henry Sun Sien Ho, Christopher Wai Sam Cheng, John Shyi‐Peng Yuen, Kenneth Chen   +18 more
doaj   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

General Urology [PDF]

Anesthesiology, 1976
openaire   +2 more sources

A prospective study using questionnaires and urodynamic assessments to evaluate bladder function and continence changes after robotic assisted radical prostatectomy

Scientific Reports
Post-prostatectomy continence status, in addition to lower urinary tract symptoms, is a major concern among patients after robotic-assisted radical prostatectomy (RaRP).
Ping-Hsuan Yu, Chih-Chieh Lin, Hsiao-Jen Chung, Tzu-Ping Lin, Eric Yi-Hsiu Huang, Tzu-Hao Huang, William J. Huang   +6 more
doaj   +1 more source

Cleveland Clinic Akron General Urology Residency Program's COVID-19 Experience. [PDF]

Urology, 2020
Vargo E, Ali M, Henry F, Kmetz D, Drevna D, Krishnan J, Bologna R.   +6 more
europepmc   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

A novel approach to cystolithotripsy with suction under local Anaesthesia: A case series from a tertiary institution

Urology Video Journal
Cystolithotripsy is a procedure performed for bladder stones that is typically done under general or regional anesthesia. This is a case series of cystolithotripsy done under local anesthesia with flexible cystoscopy and suction.A 71-year-old man with no
Julene Ong Hui Wun, Lim Yong Wei, Alvin Low Wei Xiang, Palaniappan Sundaram, Jeremy Tay Yong Jie, Lee Lui Shiong, Benjamin Lim Tze Ying   +6 more
doaj   +1 more source

Smith's general urology

, 2000
+hlm ...
MCANINCH, JACK W. (EDITOR), TANAGHO, EMIL A. (EDITOR)   +1 more
core  

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source