Results 51 to 60 of about 596,618 (263)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

STaRQ-Agent-Investigating Generalization in Knowledge Graph Question Answering via a Multi-Agent Collaborative Framework

IEEE Access
Generalization to different Knowledge Graphs (KGs) is a core challenge of Knowledge Graph Question Answering (KGQA). Current models struggle to adapt to unseen KGs due to their underlying heterogeneity. Most approaches depend on data-hungry methods, such
Longquan Jiang, Debayan Banerjee, Ricardo Usbeck   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Performance and generalizability impacts of incorporating location encoders into deep learning for dynamic PM2.5 estimation

GIScience & Remote Sensing
Deep learning models have demonstrated success in geospatial applications, yet quantifying the role of geolocation information in enhancing model performance and geographic generalizability remains underexplored.
Morteza Karimzadeh, Zhongying Wang, James L. Crooks   +2 more
doaj   +1 more source

Generalizability of Edaravone Efficacy

Muscle & Nerve
ABSTRACT The pivotal phase 3 trial MCI186‐19 (Study 19) demonstrated the efficacy of intravenous edaravone in slowing functional decline in patients with amyotrophic lateral sclerosis (ALS), leading to United States Food and Drug Administration approval.
Benjamin Rix Brooks, David L. Ennist, Danielle Beaulieu, Stephen Apple   +3 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Real-World Integration of an Automated Tool for Intracranial Hemorrhage Detection in an Unselected Cohort of Emergency Department Patients—An External Validation Study

Diagnostics
Background/Objectives: Intracranial hemorrhage (ICH) is a life-threatening condition that can be rapidly detected by non-contrast head computed tomography (NCCT). RAPID ICH is a deep learning (DL) tool for automatic ICH identification using NCCT. Our aim
Ronald Antulov, Martin Weber Kusk, Gustav Højrup Knudsen, Sune Eisner Lynggaard, Simon Lysdahlgaard, Vladimir Antonov   +5 more
doaj   +1 more source

Generalizability of experimental studies

CoRR
Experimental studies are a cornerstone of Machine Learning (ML) research. A common and often implicit assumption is that the study's results will generalize beyond the study itself, e.g., to new data. That is, repeating the same study under different conditions will likely yield similar results. Existing frameworks to measure generalizability, borrowed
Federico Matteucci, Vadim Arzamasov, Jose Cribeiro-Ramallo, Marco Heyden, Konstantin Ntounas, Klemens Böhm   +5 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Attrition and representativeness in development and validation of online symptom checkers—a case study on the Rheumatic? Questionnaire

Frontiers in Artificial Intelligence
BackgroundOnline symptom checkers are often developed and validated on data subject to self-selection and selective attrition, potentially introducing biases in prediction models.ObjectivesTo assess recruitment, selection, and attrition patterns in a ...
Floor Dijkstra Zegers, Floor Dijkstra Zegers, Ling Qin, Daniyal Selani, Georgy Gomon, Georgy Gomon, Tjardo Maarseveen, Kasper Glas, Astrid van Tubergen, Astrid van Tubergen, Yvonne Goekoop Ruiterman, Marcel Reinders, Marcel Reinders, Erik van den Akker, Erik van den Akker, Corne Baatenburg de Jong, Lars Klareskog, Barbara Axnäs, Reinhard Bos, Reinhard Bos, Saskia le Cessie, Saskia le Cessie, Rachel Knevel   +22 more
doaj   +1 more source