Results 71 to 80 of about 602,847 (266)

The case for multiple UESDs and an application to migrant deaths in the Mediterranean Sea

Political Science Research and Methods
Many recent applications of the “Unexpected Event during Survey Design” (UESD) analyze single cases of frequently occurring events. In this research note, I question the generalizability of research findings obtained this way and demonstrate the ...
Joris Frese
doaj   +1 more source

The role of replication studies in ecology

Ecology and Evolution, 2020
Recent large‐scale projects in other disciplines have shown that results often fail to replicate when studies are repeated. The conditions contributing to this problem are also present in ecology, but there have not been any equivalent replication ...
Hannah Fraser, Ashley Barnett, Timothy H. Parker, Fiona Fidler   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Concerns on Generalizability

JMIR mHealth and uHealth, 2023
openaire   +3 more sources

Are the Risk of Generalizability Biases Generalizable? A Meta-Epidemiological Study

Abstract Background Preliminary studies (e.g., pilot/feasibility studies) can result in misleading evidence that an intervention is ready to be evaluated in a large-scale trial when it is not. Risk of Generalizability Biases (RGBs, a set of external validity biases) represent study features that influence estimates of effectiveness, often ...
von Klinggraeff, Lauren, Pfledderer, Chris D., Burkart, Sarah, Ramey, Kaitlyn, Smith, Michal, McLain, Alexander C., Armstrong, Bridget, Weaver, R. Glenn, Okely, Anthony, Lubans, David, Ioannidis, John P.A., Jago, Russell, Turner-McGrievy, Gabrielle, Thrasher, James, Li, Xiaoming, Beets, Michael W.   +15 more
openaire   +2 more sources

On generalizability of MOOC models. [PDF]

, 2016
The big data imposes the key problem of generalizability of the results. In the present contribution, we discuss statistical tools which can help to select variables adequate for target level of abstraction. We show that a model considered as over-fitted in one context can be accurate in another.
Łukasz, Kidzinski, Sharma, Kshitij, Shirvani Boroujeni, Mina, Dillenbourg, Pierre   +3 more
openaire   +1 more source

Examining the effect of universal testing and treatment strategies for HIV prevention in Zambia and South Africa: generalizing the results of the HPTN 071 (PopART) trial

Journal of the International AIDS Society
Introduction HIV Prevention Trials Network (HPTN) 071 (PopART) was a cluster‐randomized trial to evaluate universal testing and treatment (UTT) strategies for HIV prevention.
Bonnie E. Shook‐Sa, Paul N. Zivich, Stephen R. Cole, Nora E. Rosenberg, Michael G. Hudgens, Deborah J. Donnell, Sizulu Moyo, Khangelani Zuma, Helen Ayles, Peter Bock, Joseph J. Eron, Richard J. Hayes, Jessie K. Edwards   +12 more
doaj   +1 more source