Results 71 to 80 of about 727,973 (288)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Conceptualizing generalizability: New contributions and a reply

, 2012
Tsang and Williams offer some good and provocative ideas in their critique of our earlier article on generalizing and generalizability. In this essay we will advance some new ideas by building on those collected in both Tsang and Williams and our ...
Allen, L., Baskerville, Richard
core  

A unified analysis on cross-architecture generalizability of coresets

Coreset selection methods aim to identify a representative subset of training data that preserves competitive performance. However, mainstream coreset selection approaches are model-specific and assume they already have full information about the target ...
Zhou, Jun, de Hoog, Frank, Chen, Diqi, Liu, Jiajun, Kusy, Brano, Gao, Yongsheng   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The ‘Real-World Approach’ and Its Problems: A Critique of the Term Ecological Validity

Frontiers in Psychology, 2020
A popular goal in psychological science is to understand human cognition and behavior in the ‘real-world.’ In contrast, researchers have typically conducted their research in experimental research settings, a.k.a. the ‘psychologist’s laboratory.’ Critics
Gijs A. Holleman, Gijs A. Holleman, Ignace T. C. Hooge, Chantal Kemner, Chantal Kemner, Chantal Kemner, Roy S. Hessels, Roy S. Hessels   +7 more
doaj   +1 more source

Generalizability of Edaravone Efficacy

Muscle & Nerve
ABSTRACT The pivotal phase 3 trial MCI186‐19 (Study 19) demonstrated the efficacy of intravenous edaravone in slowing functional decline in patients with amyotrophic lateral sclerosis (ALS), leading to United States Food and Drug Administration approval.
Benjamin Rix Brooks, David L. Ennist, Danielle Beaulieu, Stephen Apple   +3 more
openaire   +2 more sources

Improving generalizability coefficient estimate accuracy: A way to incorporate auxiliary information

, 2018
Initially proposed by Marcoulides and further expanded by Raykov and Marcoulides, a structural equation modeling approach can be used in generalizability theory estimation.
Shi, Dexin, Jiang, Zhehan, Walker, Kevin W., Cao, Jian   +3 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Predicting Methane Dry Reforming Performance via Multi-Output Machine Learning: A Comparative Study of Regression Models

Energies
Dry reforming of methane (DRM) offers a sustainable route to convert two major greenhouse gases—CH4 and CO2—into synthesis gas (syngas), enabling low-carbon hydrogen production and carbon utilization.
Sheila Devasahayam, John Samuel Thella, Manoj K. Mohanty   +2 more
doaj   +1 more source