Results 41 to 50 of about 1,254 (246)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Role and Impact of Radio Listening Practices in Older Adults’ Everyday Lives
Frontiers in Psychology, 2020 Previous research has indicated older adults value listening to music as a leisure activity. Yet, recent research into listening practices broadly has often focused on younger adults and the use of newer, digital listening technologies.
Amanda E. Krause, Amanda E. Krause
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
, 1975 We define and investigate a class of continua called weakly smooth. Smooth dendroids, weakly smooth dendroids, generalized trees, and smooth continua are all examples of weakly smooth continua.
Lewis Lum
core +2 more sources
Revista Portuguesa de Cardiologia, 2023 Introduction and objectives: High blood pressure (BP) remains a major modifiable cardiovascular (CV) risk factor. Several epidemiologic studies have been performed to assess the association between air pollution exposure and this CV risk factor but ...
Vânia Gaio +5 more
doaj +1 more source
Generalized continua. Foundations, material modeling, and uncertainty quantification.
, 2023 This dissertation is devoted to the modeling of architectured metamaterials and particle-based materials. Such materials generally necessitate the use of sophisticated continuum models to properly characterize their mechanical behavior and make accurate ...
LA VALLE, Gabriele
core
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Strain gradient and generalized continua obtained by homogenizing frame lattices
, 2018 International audienceWe determine the effective behavior of periodic structures made of welded elastic bars. Taking into account the fact that flexural and torsional stiffnesses are much smaller than the extensional one we overpass classical ...
Abdoul-Anziz, Houssam, Seppecher, Pierre
core +1 more source