Results 241 to 250 of about 72,085 (305)

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Long-Term Grazing Exclusion Reveals Taxonomic and Functional Reorganization of Plant Communities in an Insular Mediterranean Geopark. [PDF]

Plants (Basel)
Kakampoura V, Zevgolis YG, Zouros N, Panitsa M, Dimitrakopoulos PG.   +4 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Neuropsychiatric Clues to Herpes Simplex Virus Encephalitis Presenting as Normal Pressure Hydrocephalus. [PDF]

Case Rep Psychiatry
Potts CE, Kassis A, Ali A, Issa J, Alizai U, May D.   +5 more
europepmc   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Factors associated with respiratory disturbance index higher than apnea-hypopnea index in patients with obstructive sleep apnea. [PDF]

Biomed Rep
Suntrawanichakul S, Boonsawat W, Khamsai S, Sawanyawisuth K.   +3 more
europepmc   +1 more source

Trauma-Informed Psychotherapy for Complex Post-traumatic Stress Disorder in a Young Adult Woman: A Case Report. [PDF]

Cureus
Shetty YN, Trivedi GY, Bhatia G.
europepmc   +1 more source

Non-syndromic Developmental Facial Palsy Co-occurring With Chiari I Malformation: Parallel Manifestations of a Shared Prenatal Disturbance? [PDF]

Cureus
Naoun AA, Garcia Martin Y, Garcia Santiago E.   +2 more
europepmc   +1 more source

Associations between expectations and responses to chronic resistance exercise in young adults with and without analogue generalized anxiety disorder. [PDF]

Sci Rep
Rice JM, Gordon BR, Lindheimer JB, Lyons M, Herring MP.   +4 more
europepmc   +1 more source

Factors influencing early post-wildfire vegetation and implications for invasive plant management in the interior of British Columbia, Canada. [PDF]

Fire Ecol
Oeggerli VV, Martin TG, Simard SW, Grenz J.   +3 more
europepmc   +1 more source