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Disruption of functional gradients in genetic generalized epilepsy and its clinical relevance: evidence from high-density EEG

Zhang J, Rigoni I, Van De Ville D, Vulliémoz S, Roehri N.   +4 more
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Second-Line Medications for Women Aged 10 to 50 Years With Idiopathic Generalized Epilepsy.

JAMA Netw Open
Cerulli Irelli E, Cocchi E, Gesche J, Peña-Ceballos J, Caraballo RH, Lattanzi S, Strigaro G, Morano A, Moloney PB, Ferlazzo E, Pascarella A, Mazzeo A, D'Aniello A, Pizzanelli C, Milano C, Giuliano L, Viola V, Mostacci B, Fortunato F, Pulitano P, Burani M, Meletti S, Pignatta P, Perulli M, Battaglia D, Rosati E, Delanty N, Di Gennaro G, Gambardella A, Labate A, Operto FF, Giallonardo AT, Beier CP, Di Bonaventura C, Women with Epilepsy Treatment Options and Research (WETOR) study group.   +34 more
europepmc   +1 more source

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Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy

Neurology Clinical Practice, 2023
Cenobamate (CNB) is a United States Food and Drug Administration-approved antiseizure medication (ASM) for focal-onset seizures; however, its potential clinical effectiveness as a broad-spectrum ASM is not established. CNB has a proposed dual mechanism of action with preferential blockade of persistent sodium currents and positive allosteric modulation
Shruti Agashe, Gregory Worrell, Jeffrey Britton, Katherine Noe, Anthony Ritaccio, Elaine C. Wirrell, Katherine C. Nickels, Gregory D. Cascino, David Burkholder   +8 more
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Photosensitivity in generalized epilepsies

Epilepsy & Behavior, 2017
Photosensitivity, which is the hallmark of photosensitive epilepsy (PSE), is described as an abnormal EEG response to visual stimuli known as a photoparoxysmal response (PPR). The PPR is a well-recognized phenomenon, occurring in 2-14% of patients with epilepsy but its pathophysiology is not clearly understood.
Shervonne, Poleon, Jerzy P, Szaflarski
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Idiopathic generalized epilepsy

Current Treatment Options in Neurology, 2004
Successful treatment of idiopathic generalized epilepsy begins with accurate seizure classification. Seizure types, such as absence, myoclonic, and primary generalized tonic-clonic seizures (PGTCS), often can be classified based on a detailed history and inter-ictal electroencephalogram (EEG).
Joseph E., Sullivan, Dennis J., Dlugos
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Generalized epilepsies

2019
Idiopathic generalized epilepsies (IGE) are characterized by normal background EEG activity and generalized interictal spike-and-wave discharges in the absence of any evidence of brain lesion. Absence epilepsies are the prototypes of IGEs. In childhood and juvenile absence epilepsies, by definition, all patients manifest absence seizures associated ...
Guerrini R., Marini C., Barba C.
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Primary generalized epilepsies

Current Treatment Options in Neurology, 2000
For pure childhood absence epilepsy (CAE), ethosuximide (ESM) remains the drug of first choice. Although valproic acid (VPA) is of equal efficacy, it is more toxic, and is reserved for those patients with accompanying convulsions. Lamotrigine (LTG) is effective as both add-on and monotherapy for CAE.
, Murphy, , Delanty
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Idiopathic generalized epilepsies

2013
Idiopathic generalized epilepsies (IGEs) may start in infancy, childhood, or adolescence, but some have an onset in adulthood. They are genetically determined and affect otherwise healthy people of both sexes and all races, and are generally lifelong. Some, however, are age related. IGEs account for nearly a third of all epilepsies.
Roberto H, Caraballo, Bernardo, Dalla Bernardina   +1 more
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Genetic Generalized Epilepsies

Journal of Clinical Neurophysiology, 2012
In the International League Against Epilepsy's most recent revision of classification and terminology, the term idiopathic epilepsy, previously used to describe those epilepsies whose cause was unknown, but presumed genetic, has been removed. It has been replaced by the term genetic epilepsy, only to be used to describe epilepsy in which the etiology ...
William B, Gallentine, Mohamad A, Mikati
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