Results 51 to 60 of about 1,299,114 (291)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Inverses and eigenvalues of diamondalternating sign matrices
Special Matrices, 2014 An n × n diamond alternating sign matrix (ASM) is a (0, +1, −1)-matrix with ±1 entries alternatingand arranged in a diamond-shaped pattern. The explicit inverse (for n even) or generalized inverse (for nodd) of a diamond ASM is derived.
Catral Minerva +3 more
doaj +1 more source
Parallel Sum of Bounded Operators with Closed Ranges
Mathematics, 2023 Let H be a separable infinite dimensional complex Hilbert space and B(H) be the set of all bounded linear operators on H. In this paper, we present several conditions under which the distributive law of the parallel sum is valid.
Wenting Liang
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Forward Order Law for Least Squareg-Inverse of Multiple Matrix Products
Mathematics, 2019 The generalized inverse has many important applications in the aspects of the theoretic research of matrices and statistics. One of the core problems of the generalized inverse is finding the necessary and sufficient conditions of the forward order laws ...
Zhiping Xiong, Zhongshan Liu
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
A -partial isometries and generalized inverses
Linear Algebra and its Applications, 2013 Let \(A\) be a positive operator in \(B(H)\). One may consider the semi-inner product \(\langle x,y\rangle_A:=\langle Ax, y\rangle\). An operator \(T\in B(H)\) is called \(A\)-adjointable if it is adjointable with respect to \(\langle \cdot,\cdot\rangle_A\). Clearly, an \(A\)-adjoint \(T^\#\) of \(T\) exists if and only if \(AT^\#=T^*A\). Similarly, by
Arias, Maria Laura, Mbekhta, Mostafa
openaire +3 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Inversion of a Generalized Laplace Integral [PDF]
Proceedings of the National Academy of Sciences, 1942 Not ...
openaire +3 more sources
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source