Results 61 to 70 of about 517,569 (314)
Generalized Fractional-Order Discrete-Time Integrator
Complexity, 2017 We investigate a generalization of discrete-time integrator. Proposed linear discrete-time integrator is characterised by the variable, fractional order of integration/summation.
Dorota Mozyrska, Piotr Ostalczyk
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Indefinite Hamiltonian systems whose Titchmarsh–Weyl coefficients have no finite generalized poles of non-positive type [PDF]
, 2013 The two-dimensional Hamiltonian system (*) y'(x)=zJH(x)y(x), x∈(a,b), where the Hamiltonian H takes non-negative 2x2-matrices as values, and $J:= \begin{pmatrix} 0 & -1 \\ 1 & 0 \end{pmatrix}$, has attracted a lot of interest over the past decades ...
Harald Woracek +3 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The induced generalized OWA operator (WP)
, 2013 [spa] Se presenta el operador OWA generalizado inducido (IGOWA). Es un nuevo operador de agregación que generaliza al operador OWA a través de utilizar las principales características de dos operadores muy conocidos como son el operador OWA generalizado ...
Merigó Lindahl, José M. +1 more
core +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Intertwined order of generalized global symmetries
SciPost PhysicsWe investigate the interplay of generalized global symmetries in 2+1 dimensions in a lattice model that couples a $\mathbb{Z}_N$ clock model to a $\mathbb{Z}_N$ gauge theory via a topological interaction.
Benjamin Moy, Eduardo Fradkin
doaj +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Generalized Optimal Linear Orders
CoRR, 2020 210 pages, M.S. Thesis of Rishi Bommasani (Cornell University, 2020; please cite: https://ecommons.cornell.edu/handle/1813/103195)
openaire +3 more sources