Results 91 to 100 of about 769,013 (308)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Survival Under Siege: The Effect of Nutritional and Environmental Stress on Persistence in Klebsiella pneumoniae and Proteus mirabilis [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Persister cells pose a critical challenge in treating chronic and recurrent infections. This study systematically evaluated the impact of diverse stress conditions including acidic pH, osmotic pressure, nutrient and amino acid starvation, phosphate ...
Rana N. Abokhalil, Nooran S. Elleboudy, Mohammad M. Aboulwafa, Nadia A. Hassouna   +3 more
doaj   +1 more source

Ramanujan and Labos primes, their generalizations and classifications of primes

, 2009
Considering Ramanujan primes and the symmetric to them so-called Labos primes, we study their parallel properties, we study all primes with these properties (generalized Ramanujan and Labos primes) and construct two kinds of sieves for them. Finally, we give a further natural generalization of these constructions and pose some conjectures and open ...
openaire   +3 more sources

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

On generalized Dedekind prime rings

Journal of Algebra, 2008
\textit{D. D. Anderson} and \textit{B. G. Kang} [J. Algebra 122, No. 2, 323-336 (1989; Zbl 0698.13004)] and \textit{M. Zafrullah} [Mathematika 33, 285-295 (1986; Zbl 0613.13001)] investigated integral domains \(R\) satisfying \((AB)^{-1}=A^{-1} B^{-1}\) for all nonzero fractional ideals \(A\) and \(B\) of \(R\).
openaire   +1 more source

Algebraic divisibility sequences over function fields [PDF]

, 2011
In this note we study the existence of primes and of primitive divisors in function field analogues of classical divisibility sequences. Under various hypotheses, we prove that Lucas sequences and elliptic divisibility sequences over function fields ...
Mahe, Valery, Ingram, Patrick, Valéry Mahé, Marco Streng, Streng, T.C., Patrick Ingram, Streng, Marco, Katherine E. Stange, Stange, K.E., Silverman, Joseph H., Mahé, V., Joseph H. Silverman, Silverman, J.H., Ingram, P., Stange, Katherine E.   +14 more
core   +2 more sources

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Safest-Value of the Number of Primes in RSA Modulus and an Improvised Generalized Multi-Moduli RSA

Mathematics
Several attacks on the well-known RSA cryptosystem that can be extended to a multi-prime version of RSA reveal that it is preferable to use the modulus having more prime factors. On the contrary, the larger the number of prime factors of the modulus, the
Jay Mehta, Hitarth Rana
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino, Lavanya Muthukumar, Evan L. Reynolds, Peter Todd, Sinem Ovunc, Sheng Chih Jin, Zitian Tang, Simone Thomas, PNRR Study Group, Ahmet Höke, Brian C. Callaghan, Sarah Berth, Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Hristelina Ilieva, Thomas Lloyd, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Bipasha Mukherjee‐Clavin, Lyle Ostrow, Michael Polydefkis, Ricardo Roda, Charlotte Sumner   +25 more
wiley   +1 more source