Results 51 to 60 of about 45,766 (306)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
IET Generation, Transmission & Distribution, 2022 This paper presents a two‐stage resilient framework for generation and transmission expansion planning that profits static and dynamic models. The first stage problem finds the generation and transmission expansion results without considering extreme ...
Mahdi Golchoob Firoozjaee +1 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Robust generation expansion planning considering high penetration renewable energies uncertainty
Engineering Reports, 2020 The proper optimal generation expansion planning (GEP) should meet the reliability criteria requirements over a planning horizon under the presence of uncertainties.
Omar H. Abdalla +2 more
doaj +1 more source
, 2023 The increasing participation of intermittent renewable energy sources (RES) in modern power systems makes expansion and operational planning an even more complex task, especially in hydro-based systems.
Borges C. L. T. +4 more
core +1 more source
Metaheuristics for Transmission Network Expansion Planning [PDF]
, 2020 This chapter presents the characteristics of the metaheuristic algorithms used to solve the transmission network expansion planning (TNEP) problem.
Gianfranco Chicco +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
ENERGY GENERATION EXPANSION PLANNING MODEL CONSIDERING EMISSIONS CONSTRAINTS
Dyna, 2010 El problema de expansión de la generación consiste en determinar el tipo de tecnología, dimensionamiento, ubicación y momento en el cual nuevas plantas de generación deben ser integradas al sistema, en un horizonte de planeamiento dado, para satisfacer ...
DIEGO ADOLFO MEJIA GIRALDO +2 more
doaj
, 2021 Centralized generation-expansion planning is one of the well-known problems in the literature, and usually a static power transmission network is considered for this problem.
Jabarnejad M.
core +1 more source