Results 101 to 110 of about 3,718,179 (295)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

TeV Scale Seesaw and a flavorful Z' at the LHC

, 2010
Small neutrino masses and their large mixing angles can be generated at the TeV scale by augmenting the Standard Model with an additional generation dependent, anomaly-free U(1)_{nu} symmetry, in the presence of three right-handed neutrinos. The Z' gauge
E. Byckling, Jinrui Huang, M. Gell-Mann, M.-C. Chen, Mu-Chun Chen, R. N. Mohapatra, S. L. Glashow, T. Yanagida   +7 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Postculture Influence on Generation “Z”

Проблеми на постмодерността
This article aims to identify the characteristic features of postculture influencing the understanding of culture of generation Z. Culture itself is not seen as a kindred culture and spirit, but as an action and sensibility that passes from generation ...
Milena Vinarova
doaj   +1 more source

Constraints on the CMB temperature redshift dependence from SZ and distance measurements

, 2011
The relation between redshift and the CMB temperature, $T_{CMB}(z)=T_0(1+z)$ is a key prediction of standard cosmology, but is violated in many non-standard models. Constraining possible deviations to this law is an effective way to test the $\Lambda$CDM
, A Avgoustidis, A. Albrecht ., A. Avgoustidis, A. Avgoustidis, A. Avgoustidis, A. Cavaliere, A. Furuzawa ., A. Mirizzi, A. Mirizzi, A. Omont, A. Refregier ., A.G. Riess ., A.G. Riess ., A.M.R.V.L Monteiro, A.N. Aguirre, B.A. Bassett, C.J.A.P Martins, D. Nagai, D. Stern, D.E. Welty, D.J. Fixsen ., DUNE collaboration, E.S. Battistelli ., European Space Agency, G Luzzi, G. Luzzi ., H.-J. Seo, I. de Martino ., I.M.H. Etherington, J. Liske ., L. Ostman, N. Aghanim, P. Blasi, P. De Bernardis ., P. Svrček, P.P. Kronberg, Planck collaboration, R. Amanullah ., R. Jimenez, S. More, SDSS-III collaboration, SNAP collaboration, Supernova Cosmology Project collaboration   +43 more
core   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Generalized P0- and Z-matrices

Linear Algebra and its Applications, 1993
The study of linear complementarity problems often relies on the structure of the associated matrix. The same can be expected of the generalized problem. In this paper, the authors characterize the vertical block \(P_ 0\)- and \(Z\)-matrix classes. These characterizations include extensions of some of the classical results of \textit{M.
Ebiefung, A.A., Kostreva, M.M.
openaire   +1 more source

Detecting quasars at very high redshift with next generation X-ray telescopes

, 2008
The next generation of X-ray telescopes have the potential to detect faint quasars at very high redshift and probe the early growth of massive black holes (BHs). We present modelling of the evolution of the optical and X-ray AGN luminosity function at 2 <
Aird, Archibald, Babić, Barger, Barkana, Bauer, Best, Bongiorno, Boyle, Bromley, Cattaneo, Comastri, Cowie, Croom, Croton, Di Matteo, Dunn, Fan, Fan, Ferrarese, Ferrarese, Fiore, Fontanot, Fontanot, Garcia, Gaskell, Gebhardt, Gilli, Greene, Greene, Haehnelt, Haehnelt, Haiman, Hasinger, Hasinger, Hickox, Hopkins, Hopkins, Hopkins, Hopkins, Hopkins, Jiang, Kauffmann, Kauffmann, Kirsty J. Rhook, Kollmeier, Lacey, Li, Li, Madau, Maiolino, Malbon, Martin G. Haehnelt, Martínez-Sansigre, Marulli, McLure, Miyaji, Miyaji, Miyaji, Moretti, Parmar, Pei, Press, Rhook, Richards, Rines, Risaliti, Salvaterra, Shankar, Shankar, Sheth, Shields, Sijacki, Sijacki, Silk, Silverman, Simpson, Steffen, Treister, Ueda, Volonteri, Volonteri, Windhorst, Wolf, Worsley, Wyithe, Wyithe   +86 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source