Results 101 to 110 of about 394,851 (262)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Applied SciencesImproving building energy efficiency has become essential for reducing global greenhouse gas emissions. (1) Background: We aim to strengthen early-stage collaboration among stakeholders based on integrated design principles, rather than relying solely on
So-Yeon Kim, Jong-Ho Lee
doaj +1 more source
Probabilistic generative transformer language models for generative design of molecules. [PDF]
J Cheminform, 2023 Wei L, Fu N, Song Y, Wang Q, Hu J.
europepmc +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Methodological Framework for Semiconductor Fab Design Using Dynamo-Based Generative Design
Applied SciencesThe rapid growth of the semiconductor industry has created a bottleneck in which traditional manual methods for designing fabrication plants (fabs) cannot keep pace with their high complexity and short technological lifecycles.
Yeongyu Hwang +4 more
doaj +1 more source
Generative Design of Structured Materials for Controlled Frequency Responses. [PDF]
3D Print Addit Manuf, 2023 Yang W, Huang L, Singamneni S.
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
GENERATIVE DESIGN IN CULTURAL FLUX: SPATIOTEMPORAL DYNAMICS AND VALUE METRICS
Russian Studies in Culture and SocietyCulture, as the core dimension for value manifestation in generative design, exerts decisive influence on design morphology through its spatiotemporal attributes and structural characteristics.
Wei Weng
doaj +1 more source