Results 101 to 110 of about 405,858 (264)
Applied SciencesImproving building energy efficiency has become essential for reducing global greenhouse gas emissions. (1) Background: We aim to strengthen early-stage collaboration among stakeholders based on integrated design principles, rather than relying solely on
So-Yeon Kim, Jong-Ho Lee
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Methodological Framework for Semiconductor Fab Design Using Dynamo-Based Generative Design
Applied SciencesThe rapid growth of the semiconductor industry has created a bottleneck in which traditional manual methods for designing fabrication plants (fabs) cannot keep pace with their high complexity and short technological lifecycles.
Yeongyu Hwang +4 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
GENERATIVE DESIGN IN CULTURAL FLUX: SPATIOTEMPORAL DYNAMICS AND VALUE METRICS
Russian Studies in Culture and SocietyCulture, as the core dimension for value manifestation in generative design, exerts decisive influence on design morphology through its spatiotemporal attributes and structural characteristics.
Wei Weng
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Generative design and its role in developing the design of cans and packaging
الاكاديميIn the current study (generative design and its role in developing the design of cans and packaging), the researcher studied generative design and its role in developing the field of can and packaging design, which saves the effort and time needed to ...
Suha Mahmoud Taha, Ali Ghazi Matar
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Probabilistic generative transformer language models for generative design of molecules. [PDF]
J Cheminform, 2023 Wei L, Fu N, Song Y, Wang Q, Hu J.
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Generative Design of Structured Materials for Controlled Frequency Responses. [PDF]
3D Print Addit Manuf, 2023 Yang W, Huang L, Singamneni S.
europepmc +1 more source