Results 111 to 120 of about 405,858 (264)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Analysis of the application of generative artificial intelligence in interior design education
Ain Shams Engineering JournalThe rapid advancement of artificial intelligence (AI) has introduced generative AI tools as transformative resources in interior design education, enhancing creativity, aesthetic quality, and practical design outcomes.
Yao Liu +3 more
doaj +1 more source
Perfect prosthetic heart valve: generative design with machine learning, modeling, and optimization. [PDF]
Front Bioeng Biotechnol, 2023 Danilov VV +6 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Use of Generative AI to Support Inclusivity and Design Deliberation for Online Instruction
Online LearningGenerative AI presents significant opportunities for instructional designers to revolutionize content creation and personalization in online learning environments.
Jill Stefaniak, Stephanie Moore
doaj +1 more source
Open Macromolecular Genome: Generative Design of Synthetically Accessible Polymers. [PDF]
ACS Polym Au, 2023 Kim S, Schroeder CM, Jackson NE.
europepmc +1 more source
, 2017 Today it is increasingly essential to fully understand the potential of the software, now able to let us hire more awareness in the control of the project, but especially in the potential of new forms of development. Evolved codes and programming languages are already available and, as well as giving many ideational possibilities, place their ...
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source