Results 111 to 120 of about 394,851 (262)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Generative design and its role in developing the design of cans and packaging
الاكاديميIn the current study (generative design and its role in developing the design of cans and packaging), the researcher studied generative design and its role in developing the field of can and packaging design, which saves the effort and time needed to ...
Suha Mahmoud Taha, Ali Ghazi Matar
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Perfect prosthetic heart valve: generative design with machine learning, modeling, and optimization. [PDF]
Front Bioeng Biotechnol, 2023 Danilov VV +6 more
europepmc +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Open Macromolecular Genome: Generative Design of Synthetically Accessible Polymers. [PDF]
ACS Polym Au, 2023 Kim S, Schroeder CM, Jackson NE.
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural Optimization Design of Dual Robot Gripper Unloading Device Based on Intelligent Optimization Algorithms and Generative Design. [PDF]
Sensors (Basel), 2023 Jia J +5 more
europepmc +1 more source
, 2017 Today it is increasingly essential to fully understand the potential of the software, now able to let us hire more awareness in the control of the project, but especially in the potential of new forms of development. Evolved codes and programming languages are already available and, as well as giving many ideational possibilities, place their ...
openaire +1 more source