Results 41 to 50 of about 2,274,473 (277)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2009 Let X be a smooth projective variety of dimension n in P^r. We study the fibers of a general linear projection pi: X --> P^{n+c}, with c > 0. When n is small it is classical that the degree of any fiber is bounded by n/c+1, but this fails for n >> 0.
David Eisenbud +7 more
core +2 more sources
Generic separating sets for 3D elasticity tensors [PDF]
, 2018 We define what is a generic separating set of invariant functions (a.k.a. a weak functional basis) for tensors. We produce then two generic separating sets of polynomial invariants for 3D elasticity tensors, one made of 19 polynomials and one made of 21 ...
Auffray, Nicolas +4 more
core +4 more sources
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
A comparative analysis of the microbiome of cigars produced in the Caribbean and China
Scientific ReportsFermentation of cigar tobacco leaves involves intense microbial activity, and hence, microorganisms have a significant impact on the quality and flavour of cigars. However, research on the correlation between microbial communities and the sensory quality
Bo Ding +10 more
doaj +1 more source
, 2016 Dan Rudolph showed that for an amenable group $\Gamma$, the generic measure-preserving action of $\Gamma$ on a Lebesgue space has zero entropy. Here this is extended to nonamenable groups.
Bowen, Lewis
core +2 more sources
Decompositions of ideals of minors meeting a submatrix [PDF]
, 2015 We compute the primary decomposition of certain ideals generated by subsets of minors in a generic matrix or in a generic symmetric matrix, or subsets of Pfaffians in a generic skew-symmetric matrix.
Neuerburg, Kent M., Teitler, Zach
core +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Generic uniqueness of a structured matrix factorization and applications in blind source separation
, 2016 Algebraic geometry, although little explored in signal processing, provides tools that are very convenient for investigating generic properties in a wide range of applications. Generic properties are properties that hold "almost everywhere". We present a
DeLathauwer, Lieven, Domanov, Ignat
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source