Results 131 to 140 of about 280,132 (308)
The Norwegian market for pharmaceuticals and the non-mandatory substitution reform of 2001: The case of enalapril [PDF]
, 2004 A new demand model which accounts for the effect of the age of drugs on pharmaceutical demand is provided. Within this framework the problem of persistence in consumption of original branded drugs and a particular case of intra-molecular substitution are
Razzolini, Tiziano
core
Advanced Science, EarlyView.G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li +8 more
wiley +1 more source
Advanced Science, EarlyView.INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv +11 more
wiley +1 more source
Regulation, generic competition and pharmaceutical prices: Theory and evidence from a natural experiment [PDF]
We study the impact of regulatory regimes on generic competition and pharmaceutical pricing using a unique policy experiment in Norway, where reference pricing (RP) replaced price cap regulation in 2003 for a sub-sample of off-patent products. We exploit
Kurt R. Brekke +2 more
core
Advanced Science, EarlyView.This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu +9 more
wiley +1 more source
Is It Possible to Have Cheaper Drugs and Preserve the Incentive to Innovate: Reforming the Drug Approval Process According to Market Principles [PDF]
This paper argues that drugs are expensive not because of a lack of competition among research-based pharmaceutical companies, but because of a lack of competition in the drug approval process.
Corinne Sauer, Robert Sauer
core
Advanced Science, EarlyView.A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li +6 more
wiley +1 more source
Physicians' perceptions of generic drugs in China. [PDF]
Health Policy Open, 2022 He JH, Shang DW, Wang ZZ, Li XF, Wen YG.
europepmc +1 more source
Revitalisasi Penggunaan Obat Generik [PDF]
, 2011 The government through the Ministry of Health is very serious about revitalizing the use of generic drugs by issuing a policy that stipulated in the Regulation of the Minister of Health No. HK.
Yunarto, N. (Nanang)
core
Advanced Science, EarlyView.Mid‐infrared photothermal imaging enables multidimensional profiling of micro‐ and nanoplastics in bottled water. A total of 9.9 × 104 particles L−1 is detected, with 64% in the nanoscale regime. Spectral evolution, including peak narrowing and band shifts, reveals local chain reorganization in polyethylene terephthalate (PET), highlighting intrinsic ...
Xinyu Deng +4 more
wiley +1 more source