Results 151 to 160 of about 1,550,569 (253)

Advances in quantitative methods and modeling for complex generic drugs and opportunities to hybridize learnings between innovator and generic drug developers. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Jayachandran P.
europepmc   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Breaking barriers: how generic drugs democratize mental health. [PDF]

Front Pharmacol
Rosas-Sánchez GU, Mercado-Serna M, Fernández-Demeneghi R, Pérez-Vega MI, Soria-Fregozo C.   +4 more
europepmc   +1 more source

Attitude and Purchase Intention to Generic Drugs. [PDF]

Int J Environ Res Public Health, 2021
Arcaro R, da Veiga CRP, da Silva WV, Pereira da Veiga C, Pereira da Veiga C.   +4 more
europepmc   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

The impact of the consistency evaluation policy of generic drugs on the integration of innovation chain and industrial chain in the pharmaceutical manufacturing industry. [PDF]

Front Public Health
Xie Y, Zhang W.
europepmc   +1 more source

Reports of side effects associated with the use of drugs 1986

, 1986
During 1986 the National Drugs Advisory Board received 1,188 reports of adverse reactions from which 2,454 side effects were recorded. These results represent an increase of approximately 20% in reporting.
National Drugs Advisory Board (NDAB)
core  

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Potential impact of tariffs on active pharmaceutical ingredients on the price of US-made generic drugs. [PDF]

Health Aff Sch
Socal MP, Sun Y, Ballreich J, Acha J, Yazdi MA, Dai T, Dada M.   +6 more
europepmc   +1 more source

Pharmacy Benefit Manager Pricing and Spread Pricing for High-Utilization Generic Drugs.

JAMA Health Forum, 2023
Mattingly TJ, Ben-Umeh KC, Bai G, Anderson GF.   +3 more
europepmc   +1 more source