Results 151 to 160 of about 276,945 (256)

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, EarlyView.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

Depolymerization and Reuse of Polycarbonates: Emerging Classes, Mechanisms and Challenges

Angewandte Chemie, EarlyView.
This review collects the latest developments in the area of chemical and catalytic polycarbonate recycling strategies and includes the controlled degradation of similar types of macromolecules. Apart from the main strategies for deconstruction, the key mechanistic features of these depolymerization processes are also discussed together with the ...
Davide Rigo, David H. Lamparelli, Antonio Buonerba, Carmine Capacchione, Arjan W. Kleij   +4 more
wiley   +2 more sources

Can We Trust the Quality of Generic Drugs? [PDF]

J Manag Care Spec Pharm, 2020
Eban K.
europepmc   +1 more source

Generalized pustular drug eruptions

Journal of the European Academy of Dermatology and Venereology, 1999
Koumantaki-Mathioudaki, E, Papadavid, E, Katsambas, A   +2 more
openaire   +3 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Physicochemical and Mechanical Characterization of Commercial Collagen‐Based Wound Dressings

Advanced NanoBiomed Research, EarlyView.
Commercial collagen‐based wound dressings are systematically compared to reveal how porous architecture governs hydration‐driven swelling and mechanical adaptation. Distinct structure–function relationships are identified, showing that wet‐state elasticity and conformability emerge from material composition and processing rather than manufacturer ...
Davide V. Verdolino, David M. Warde, Helen A. Thomason, Kimberly A. Mace, Sarah H. Cartmell   +4 more
wiley   +1 more source

Bioequivalence trials for the approval of generic drugs in Saudi Arabia: a descriptive analysis of design aspects. [PDF]

BMC Med Res Methodol
Althunian TA, Alzenaidy BR, Alroba RA, Almadani OA, Alqahtani FA, Binajlan AA, Almousa AI, Alamr DK, Al-Mofada MS, Alsaqer NY, Alarfaj HA, Bahlewa AA, Alharbi MA, Alhomaidan AM, Alsuwyeh AA, Alsaleh AA.   +15 more
europepmc   +1 more source

Prescribing Behavior of General Practitioners for Generic Drugs. [PDF]

Int J Environ Res Public Health, 2020
Tuncay B, Pagano S, De Santis M, Cavallo P.   +3 more
europepmc   +1 more source

Generic Drugs Post Novo Nordisk [PDF]

, 2012
Kalter, Alexander J.
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