Results 41 to 50 of about 80,629 (260)
Advanced Materials, EarlyView.The water permeability of amorphous carbon dots (CDs) is demonstrated by investigating their plasticization. Novel polyamide‐based and amorphous nanoparticles are synthesized by controlling their inner packing density. Water plasticization is evidenced by the decrease of the CDs glass transition temperature with increasing the hydration degree.
Elisa Sturabotti +8 more
wiley +1 more source
AAPS OpenThis paper examines the standardization of bioequivalence (BE) administration methods for chewable tablets and other dosage forms instructing chewing in alignment for generic drug development.
Hye Lim Lim +4 more
doaj +1 more source
In Silico Methods for Development of Generic Drug–Device Combination Orally Inhaled Drug Products
CPT: Pharmacometrics & Systems Pharmacology, 2019 The development of generic, single‐entity, drug–device combination products for orally inhaled drug products is challenging in part because of the complex nature of device design characteristics and the difficulties associated with establishing ...
Ross L. Walenga +2 more
doaj +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2023 This report summarizes the proceedings for day 2 sessions 1 and 3 of the 2‐day public workshop entitled “Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches,” a jointly sponsored workshop by the US Food and Drug ...
Fang Wu +17 more
doaj +1 more source
Advanced Materials, EarlyView.ABSTRACT Microneedle arrays (MNAs) is a rapidly emerging technology with broad biomedical applications in drug delivery and biosensing. With sub‐millimeter dimensions and periodicity, MNAs possess geometries nearly ideal for biomedical devices operating within the terahertz (THz) spectral window.
Sang Hyun Lee +6 more
wiley +1 more source
Generic drugs: benefit/risk ratio
Неврология, нейропсихиатрия, психосоматика, 2021 The review discusses the interchangeability of medications, approaches to the registration of original and generic drugs, and types of their equivalence, as well as problems with generics in clinical practice.
E. A. Ushkalova +2 more
doaj +1 more source
Multilayered Digital Microfluidic Chip for Cell‐Based Assays
Advanced Materials Interfaces, EarlyView.A multilayered digital microfluidic (mDMF) chip architecture is introduced to improve throughput and robustness in cell‐based assays. By multilayering electrode components and dielectric layers on glass, this design significantly reduces actuation voltage, maintains reliability, and enables expansion of the operational area with minimum current leakage.
Mert Ozden +2 more
wiley +1 more source
Femtosecond‐Laser Mould Texturing Enables Tunable Biointerfaces in COC Microfluidics
Advanced Materials Interfaces, EarlyView.Femtosecond‐laser texturing of injection‐mould inserts enables scalable engineering of biointerfaces in cyclic olefin copolymer microfluidics. Replicated micro‐ and nano‐topographies modulate surface roughness and wettability, leading to texture‐dependent protein adsorption and cell adhesion without chemical post‐processing.
Irene Varela‐Leniz +9 more
wiley +1 more source
Evaluation of model‐based bioequivalence approach for single sample pharmacokinetic studies
CPT: Pharmacometrics & Systems Pharmacology, 2023 In a traditional pharmacokinetic (PK) bioequivalence (BE) study, a two‐way crossover study is conducted, PK parameters (namely the area under the time‐concentration curve [AUC] and the maximal concentration [Cmax]) are obtained by noncompartmental ...
Coralie Tardivon +10 more
doaj +1 more source
Topography‐Regulated Screening Platform for Myoblast Contact Guidance
Advanced Materials Technologies, EarlyView.This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng +6 more
wiley +1 more source