Results 111 to 120 of about 243,880 (305)

Aberrant Methylation Profile and Microsatellit Instability in Turkish Sporadic Colorectal Carcinoma

Bezmiâlem Science, 2019
Objective:Genomic DNA obtained from paraffin blocks of the intended colorectal cancer cases was evaluated for promoting colorectal cancer by investigating the promoter methylation of 6 different gene promoter regions and microsatellite instability ...
Cumhur Gökhan EKMEKÇİ, Mine GÜLLÜOĞLU, Yersu KAPRAN, Ferhunde DİZDAROĞLU, Uğur ÖZBEK   +4 more
doaj   +1 more source

ANALYSIS OF TP53, APC, KRAS, AND MMR GENETIC MUTATIONS IN COLORECTAL CANCER: A REVIEW ARTICLE [PDF]

Sanamed
Introduction: Colorectal cancer (CRC) is one of the most common malignancies with significant global health and economic implications. Genetic mutations in genes such as TP53, APC, KRAS, and MMR play a crucial role in the development and progression of ...
Gavric Igor, Hodzic Edin, Sarajlic Lana, Salibasic Mirhan, Bajramagic Salem, Dizdarevic Advan, Kulovic Edin   +6 more
doaj   +1 more source

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers. [PDF]

, 2013
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-
Adler, Thure, Amodio, Stefania, Betsholtz, Christer, Betsholtz, Ingrid Holmberg, Busch, Dirk H., Casola, Stefano, Castelletti, Daniela, Di Fiore, Pier Paolo, Fuchs, Helmut, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Lucano, Caterina, Offenhäuser, Nina, Pozzi, Benedetta, Rathkolb, Birgit, Ronzoni, Simona, Sciullo, Anna, Treise, Irina, Wolf, Eckhard   +18 more
core   +2 more sources

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Genetic and Epigenetic Changes of Components Affecting the WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability

Neoplasia: An International Journal for Oncology Research, 2005
An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or promoter hypermethylation of five components of the WNT signaling cascade [APC, CTNNB1 (encoding
Lin Thorstensen, Guro E. Lind, Tone Løvig, Chieu B. Diep, Gunn I. Meling, Torleiv O. Rognum, Ragnhild A. Lothe   +6 more
doaj   +1 more source

APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and Hyperplastic Polyps

Cancer Informatics, 2020
Aberrant activation of the WNT/CTNNB1 pathway is notorious in colorectal cancer (CRC). Here, we demonstrate that the expression of specific and crucial WNT signaling pathway genes is linked to disease progression in colonic adenomatous (AP) and ...
Sama Rezasoltani, Mahrooyeh Hadizadeh, Mina Golmohammadi, Ehsan Nazemalhossini-Mojarad, Sina Salari, Hamid Rezvani, Hamid Asadzadeh-Aghdaei, Michael Ladomery, Chris Young, Fakhrosadat Anaraki, Sarah Almond, Maziar Ashrafian Bonab   +11 more
doaj   +1 more source

Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes. [PDF]

, 2016
Mu-protocadherin (MUCDHL) is an adhesion molecule predominantly expressed by colorectal epithelial cells which is markedly downregulated upon malignant transformation.
Calabretta, Bruno, Ferrari, Stefano, Ferrarini, Fabrizio, Gemelli, Claudia, Grande, Alexis, Losi, Lorena, Manco, Gianrocco, Montorsi, Lucia, Parenti, Sandra, Rossi, A, Tagliafico, Enrico, Zanocco-Marani, Tommaso   +11 more
core   +2 more sources

Alleles of the APC gene: An attenuated form of familial polyposis

Cell, 1993
An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosome 5q.
Lisa Spirio, Sylviane Olschwang, Joanna Groden, Margaret Robertson, Wade Samowitz, Geoff Joslyn, Lawrence Gelbert, Andrew Thliveris, Mary Carlson, Brith Otterud, Henry Lynch, Patrice Watson, Patrick Lynch, Pierre Laurent-Puig, Randall Burt, J.P. Hughes, Gilles Thomas, Mark Leppert, Ray White   +18 more
openaire   +2 more sources

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Next-generation sequencing of prostate cancer: genomic and pathway alterations, potential actionability patterns, and relative rate of use of clinical-grade testing. [PDF]

, 2019
Despite being one of the most common cancers, treatment options for prostate cancer are limited. Novel approaches for advanced disease are needed. We evaluated the relative rate of use of clinical-grade next generation sequencing (NGS) in prostate cancer,
Carter, Jennifer L, Elkin, Sheryl K, Ikeda, Sadakatsu, Kurzrock, Razelle, Tomson, Brett N   +4 more
core