Results 31 to 40 of about 44,727 (269)
Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2 for a defined personal and family history in an Ashkenazi Jewish woman (LAMBDA) [PDF]
, 2003 INTRODUCTION: Ancestral mutations in BRCA1 and BRCA2 are common in people of Ashkenazi Jewish descent and are associated with a substantially increased risk of breast and ovarian cancer.Ellen Solomon, Fisher, S A, Lewis, C M; id_orcid, Lewis, CM, Southey, MC, John L Hopper, Hodgson, SV, Venter, DJ, Michael Friedlander, Hopper, JL, Hopper, J L, Solomon, E, Bankier, A, Hooper, J L, Cathryn M Lewis, Tucker, K, Melissa C Southey, Southey, M C, Lesley Andrews, Friedlander, M, Carmel Apicella, Hodgson, S V, Fisher, SA, Katherine Tucker, Venter, D J, Agnes Bankier, Apicella, C, Deon J Venter, Andrews, L, Shirley V Hodgson, Sheila A Fisher +30 morecore +1 more sourceGenetic predisposition to male breast cancer in Poland
BMC Cancer, 2021 Background Breast cancer in men accounts for fewer than 1 % of all breast cancer cases diagnosed in men and women. Genes which predispose to male breast cancer include BRCA1 and BRCA2. The role of other genes is less clear.Marek Szwiec, Joanna Tomiczek-Szwiec, Wojciech Kluźniak, Dominika Wokołorczyk, Karolina Osowiecka, Robert Sibilski, Małgorzata Wachowiak, Jacek Gronwald, Helena Gronwald, Jan Lubiński, Cezary Cybulski, Steven A. Narod, Tomasz Huzarski +12 moredoaj +1 more sourceCase Review: Whole-Exome Sequencing Analyses Identify Carriers of a Known Likely Pathogenic Intronic BRCA1 Variant in Ovarian Cancer Cases Clinically Negative for Pathogenic BRCA1 and BRCA2 Variants [PDF]
, 2022 Background: Detecting pathogenic intronic variants resulting in aberrant splicing remains a challenge in routine genetic testing. We describe germline whole-exome sequencing (WES) analyses and apply in silico predictive tools of familial ovarian cancer ...El Haffaf, Z, Patricia N. Tonin, Alenezi, WM, Fierheller, CT, William D. Foulkes, Zaki El Haffaf, Wejdan M. Alenezi, Corinne Serruya, Anne-Marie Mes-Masson, Revil, T, Mes-Masson, A-M, Diane Provencher, Jiannis Ragoussis, Timothée Revil, Foulkes, WD, Ragoussis, J, Tonin, PN, Caitlin T. Fierheller, Provencher, D, Serruya, C +19 morecore +1 more sourceOverexpression of BRCA2 gene in sporadic breast tumours [PDF]
Oncogene, 1999 The breast cancer susceptibility gene BRCA2 is expressed in a wide range of tissues as an 11-kb mRNA transcript that encodes a 3418-amino acid protein involved in the response to DNA damage. To obtain better a molecular characterization of BRCA2 expression in sporadic breast cancer, we quantified BRCA2 mRNA by means of RT - PCR in a large series of ...I, Bièche, C, Noguès, R, Lidereauopenaire +2 more sourcesEvaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) [PDF]
, 2009 BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and ...Rodriguez, GC, S V Blank, Gomez Garcia, E. B., O Barnett-Griness, Caligo, M A, de la Hoya, M.,, Schaefer, D.,, SWE-BRCA, Fricker, J. P., Imyanitov, E.N., Engel, C., H T Lynch, Spiess, A.C., Olivier-Faivre, L, Douglas, F., D Frost, E N Imyanitov, Rennert, G. (Gad), Meindl, A., Gschwantler-Kaulich, D. (Daphne), K Offit, De La Hoya, M., Couch, F.J. (Fergus), Milne, R.L. (Roger), Peyrat, JP, Schaefer, D., Johannsson, O.T., Ozcelik, H.,, Askmalm, M. S., Viel, A., Hogervorst, F. B.L., Bergman, Annika,, Arnold, N, Mai, P.L. (Phuong), C F Singer, Hopper, JL, Morrison, Patrick, Sinilnikova, O. M., Blank, S.V. (Stephanie), Weerasooriya, N.,, Group, EMBRACE, Douglas, F. (Fiona), M B Terry, A van den Ouweland, Dagan, E., Manoukian, S.,, Niederacher, D, Allavena, A., Froster, U.G. (U.), O M Sinilnikova, Versmold, B., Hansen, Thomas V.O., Revillion, F.,, Nevanlinna, H.,, Milne, R L, Radice, P.,, Boggess, J.F., Neuhausen, S.L. (Susan), Ding, Y C,, Easton, D F, Osorio, A, S Giraud, Dagan, E, Askmalm, M S, Evans, D.G. (Gareth), Benítez, J. (Javier), Muller, D, Rennert, G, Gómez García, EB, Claes, K.,, Moncoutier, V. (Virginie), Allavena, A, E M John, Moncoutier, V.,, L Barjhoux, F Révillion, Boggess, J F, Pita, G., Peyrat, J. -P, Antoniou, A C, Greene, M. H., S L Neuhausen, Wijnen, JT, Schwartz, P.E. (Peter), Hansen, T.v.O, Schaefer, D. (D.), A B Spurdle, Basil, J., Claes, K., Hopper, J. L., Fricker, J-P, Hansen, T.V., Milne, R.L., Eeles, R., Hopper, J.L., Cajal, T.R.Y., Godwin, AK, Buys, S., Varon-Mateeva, R, P Radice, Jernström, H. (H.), N. Imyanitov, E., Giraud, S. (Sophie), Fiebig, B.,, Montagna, M., Casella, C. (Cinzia), J Brunet, Group, GEMO, Barnett-Griness, O., A Meindl, Allavena, A. (Anna), S Peock, Simard, J. (Jacques), Jernström, Helena, van den Ouweland, A.,, Manoukian, S. (Siranoush), A E Toland, C Engel, Cassini, C., Peyrat, J-P,, Wang, X.,, Cruger, D G, Kaufman, B.,, Verhoef, S, Kirchhoff, T., Barnett-Griness, O.,, Blank, S V, Luccarini, C, A Osorio, Oliver, C T, Goldgar, D.,, Meindl, A, R Gershoni-Baruch, Pfeiler, G. (Georg), J Cook, Szabo, C.I., Kircchoff, T. (Tomas), E. Schwartz, P., Hamann, U. (Ute), Giraud, S, U G Froster, Boggess, JF, Arver, B. (Brita Wasteson), T. Johannsson, O.,, Kaufman, B. (Bella), Muller, D.W. (Danièle), Chen, X.C. (X. C.), G Pita, Tizzoni, L., Froster, U.G., Olivier-Faivre, L.,, Kosarin, K.,, Peterlongo, P, Oliver, C.T., Faivre, L. (Laurence), Milne, RL, Kosarin, K., Andrulis, I. L., Ozcelik, H, Manoukian, S., Antoniou, A.C. (Antonis), Peock, S. (Susan), Nathanson, K L,, Thomassen, M. (Mads), Domchek, SM, Pita, G. (Guillermo), Pfeiler, G.,, Tizzoni, L. (Laura), Schwartz, PE, Moncoutier, V., E Friedman, Mai, P., J Simard, Andrulis, I.L. (Irene), Caligo, MA, Heikinen, T. (Tuomas), Hogervorst, F.B., Schmutzler, RK, Gomez Garcia, E.B., F J Couch, Simard, J.,, Luccarini, C.,, Laitman, Y., Gerdes, A-M. (Anne-Marie), E. Toland, A.,, Spiess, A.-C., Ozcelik, H. (Hilmi), Garcia, E.B.G., Oliver, C.T. (Clare), Morrison, P J,, Eeles, R.,, Evans, D G,, S Cohen, Couch, F J, Domchek, S.M., Gomez Garcia, E B, Ditsch, N.,, B Arver, Caldes, T.,, Deissler, H., McGuffog, L. (Lesley), Weerasooriya, N, Hogervorst, F B L, Kirchhoff, T, Hansen, TV, Terry, MB, Frost, D., Spiess, A. C., Hansen, TVO, Hamann, U, Antoniou, AC, N Arnold, Spiess, AC, Luccarini, C. (Craig), Offit, K, Frost, D, Lynch, H T, Barjhoux, L. (Laure), Cook, J., Greene, M H, J-P Peyrat, F Douglas, Andrulis, I L,, EB Gómez García, Schmutzler, R. K., John, EM, KConFab, S Healey, D G Evans, Beesley, J.,, Caldes, T. (Trinidad), Claes, Kathleen, Beesley, J. (Jonathan), Nathanson, K.L. (Katherine), F Lejbkowicz, Offit, K.,, Kaufman, B, Wang, X, Muller, D., Heikkinen, T., Lalloo, F., Jernström, H, Evans, D G, Kontorovich, T. (Tair), G Pichert, Lalloo, F.,, Cook, M., Pichert, G., C. Rodriguez, G., Askmalm, M.S., B Malmer, Singer, C F, A-M Gerdes, Domchek, S M, C Cassini, Ding, Y. C., Yassin, Y. (Yosuf), Godwin, A.K. (Andrew), McGuffog, L., Buys, S, Weerasooriya, N. (Nayana), Spurdle, A B,, Miron, A., M Piedmonte, Miron, A. (Alexander), Gershoni-Baruch, R.,, Fricker, J.P., Laitman, Y.,, Caldes, T., Hamann, U.,, M Montagna, Sinilnikova, OM, Friedman, E.,, Pfeiler, G., Cruger, D.G., Ozcelik, H., G. Froster, U., Ditsch, N. (Nina), Froster, UG, Stoppa-Lyonnet, D., Peterlongo, P. (Paolo), Terry, M B,, Y C Ding, Toland, A E, Zikan, M., Daly, M.B. (Mary), L McGuffog, Pita, G.,, Versmold, B, Engel, C.,, Morrison, PJ, Oliver, C T,, J F Boggess, B Kaufman, Caldes, T, Hoya, M. (Miguel) de La, D Niederacher, A Allavena, Hogervorst, FB, Easton, D. F., Stoppa-Lyonnet, D, Peterlongo, P., Stoppa-Lyonnet, D. (Dominique), Caligo, M A,, Montagna, M, Viel, A. (Alessandra), Couch, F. J., Cook, M.,, G. Froster, U.,, GEMO, Zikan, M, Y Yassin, Wijnen, J.T., Family Registry, Breast Cancer, Rodriguez, G. C., Neuhausen, S.L., J Benítez, T Ramón y Cajal, Cruger, DG, Barjhoux, L.,, A C Antoniou, Pichert, G, J Beesley, Nathanson, K. L., S M Domchek, Benitez, J.,, Healey, S, Douglas, F.,, Ramon Y Cajal, T., P Peterlongo, EMBRACE, Group, HEBON, Toland, A.E., Group, KConFab, Greene, M.H., Nevanlinna, H., Hoya, M. de la, Boggess, J.F. (John), Ding, Y C, Gschwantler-Kaulich, D.,, Nathanson, K L, G Chenevix-Trench, Hodgson, S.,, Garcíla, E. B. G., Antoniou, A.C., N. Imyanitov, E.,, Blank, SV, Singer, CF, Yassin, Y.,, Friedman, E, Gerdes, A. M., Andrulis, IL, Mai, P.,, Fricker, J.P. (Jean Pierre), Breast Cancer Family Registry, Stenmark Askmalm, Marie, Lynch, H.T., Deissler, H.,, Wakeley, K., Goldgar, D., Claes, K, H Ozcelik, M Barile, Szabo, C. I., Barjhoux, L., Nevanlinna, H, Caligo, M.A. (Maria), Schmutzler, R K, Goldgar, D, Laitman, Y. (Yael), Nevanlinna, H. (Heli), Van Den Ouweland, A., Morrison, P. J., Pichert, G.,, Chen, X., Yannoukakos, D.,, Hansen, Thomas V O, Simard, J., Easton, D.F., Arver, B.,, Godwin, A K,, V. Blank, S., Johannson, O.T. (Oskar), Radice, P, Frost, D.,, Chenevix-Trench, G., Basil, J.,, Sinilnikova, O.M., Brunet, J.,, Ding, Y.C., U Hamann, K. Schmutzler, R.,, Cassini, C, Imyanitov, EN, Hansen, T.V.O. (Thomas), Hansen, T. V. O., Gerdes, A-M,, K. Schmutzler, R., H Deißler, Garcia, E.B. Gomez, Healey, S. (Sue), J-P Fricker, Sinilnikova, O M, C I Szabo, Foretova, L., Garcia, EBG, Gershoni-Baruch, R, Versmold, B.,, Fiebig, B. (Britta), M S Askmalm, Niederacher, D., F Lalloo, Fricker, JP, Zikan, M.,, Douglas, F, Barnett-Griness, O, Miron, A.,, Gomez Garcia, E B,, S Manoukian, Greene, MH, R L Milne, N Ditsch, Piedmonte, M, Kontorovich, T., J Basil, Rodriguez, G C, Chenevix-Trench, G.,, Greene, M.H. (Mark), Osorio, A.,, Friedman, E., Milne, R L,, Hopper, J L, Froster, U. G., R Eeles, Basil, J, Cassini, C. (C.), Blank, S.V., Lynch, H. (Henry), Morrison, P J, A-C Spiess, Spurdle, Amanda B., Spurdle, AB, Lynch, HT, Domchek, S.M. (Susan), v. O. Hansen, Thomas,, Godwin, A K, Ramón Y Cajal, T, Moncoutier, V, T Caldes, Sinilnikova, O M,, Wakeley, K.,, Evans, DG, John, E.M. (Esther), Hogervorst, F.B.L. (Frans), Giraud, S., v. O. Hansen, Thomas, D Yannoukakos, Peyrat, J. P., A Miron, Johannsson, O T, Terry, M. B., Miron, A, L Foretova, Chen, X.,, Piedmonte, M.,, M A Caligo, Fiebig, B, Schaefer, D, S Hodgson, Szabo, C I,, Spiess, A. -C, Kirchhoff, T.,, Andrulis, I L, Daly, M.,, Hogervorst, FBL, Cajal, T. Ramon y,, Oliver, CT, Casella, C., Ditsch, N, R Varon-Mateeva, John, E M, Spiess, A-C,, Group, SWE-BRCA, Gerdes, A.-M., Y Laitman, Pfeiler, G, Fricker, J. -P, Pita, G, Mai, P, Giraud, S.,, Kosarin, K. (Kristi), C Casella, Lejbkowicz, F. (Flavio), Yannoukakos, D. (Drakoulis), X Wang, Claes, K. (Kathleen), Buys, S. M., Révillion, F, Imyanitov, E.N. (Evgeny), Cruger, D. G., Schmutzler, R.K. (Rita), Ramon, Y.Cajal, K Wakeley, P Mai, Nathanson, K.L., Ditsch, N., Lindor, N.,, Arnold, N.,, Group, OCGN, G Rennert, Morrison, P.J., Chenevix-Trench, G, G Pfeiler, Arver, B., B Fiebig, Couch, FJ, Offit, K., Evans, D.G., Schwartz, P.E., Hogervorst, F. B. L., Ouweland, A.M.W. (Ans) van den, Malmer, Beatrice,, Eeles, R, Szabo, C I, Tizzoni, L, Healey, S., Hodgson, S., E. Toland, A., S Verhoef, Benítez, J, Singer, C F,, Montagna, M.,, Foretova, L.,, T Heikkinen, Engel, C, John, E. M., Dagan, E. (Efrat), V Moncoutier, Yannoukakos, D., M H Greene, Toland, A.E. (Amanda), Froster, U G, Domchek, S M,, Neuhausen, S. L., Cajal, T. Ramon y, Rennert, G.,, Kontorovich, T.,, Beesley, J, Meindl, A.,, McGuffog, L.,, Jernstrom, H., Heikkinen, T.,, OCGN, Malmer, B, J T Wijnen, K Kosarin, Johannsson, OT, Schwartz, P E, F. Boggess, J., Garcíla, EBG, Laitman, Y, Yannoukakos, D, Allavena, A.,, Couch, F.J., Hodgson, S.V. (Shirley), C T Oliver, Kontorovich, T, Szabo, CI, Niederacher, D.,, Daly, M., Chen, X, D Muller, Foretova, L, Yassin, Y., Hamann, U., Spurdle, A B, Toland, AE, T Kirchhoff, Wang, X., Peyrat, J.P., John, E M,, Barile, M, M Thomassen, Cruger, D. (Dorthe), Hansen, Thomas v. O., E Dagan, E. Schwartz, P.,, Caligo, M. A., Wakeley, K. (Katie), Buys, S.S. (Saundra), S Buys, Manoukian, S, Brunet, J., Spurdle, A.B., Benitez, J., A K Godwin, M Cook, Neuhausen, SL, Viel, A, Simard, J, Milne, R. L., Casella, C.,, Cohen, S.,, Lindor, N., Cook, J. (Jackie), Healey, S.,, Muller, D.,, M de la Hoya, Stoppa-Lyonnet, D.,, Ding, YC, Couch, F J,, Thomas v O Hansen, Lynch, H T,, CMBA, Thomassen, M.,, Verhoef, S.,, H Jernström, D Gschwantler-Kaulich, Peterlongo, P.,, Imyanitov, E. N., Brunet, J, Toland, A. E., Offit, K. (Kenneth), N Lindor, Rodriguez, G.C. (Gustavo), Arnold, N., Gerdes, A-M, D Schaefer, Garcíla, E.B.G. (E.B. Gómez), Thomassen, M, O T Johannsson, Rennert, G., Yassin, Y, Gershoni-Baruch, R., Cook, J.,, Gschwantler-Kaulich, D., Neuhausen, S L,, K Claes, C. Rodriguez, G.,, Tizzoni, L.,, Barjhoux, L, Revillion, F., Dagan, E.,, John, E.M., Malmer, B. (Beatrice), Brunet, J. (Joan), P E Schwartz, Easton, DF, Fiebig, B., Boggess, J. F., Terry, M.B., Piedmonte, M., Jernstrom, H.,, Hogervorst, F.B.L., Meindl, A. (Alfons), García, Eb Gómez, Blank, S. V., P J Morrison, C Luccarini, Hopper, J.L. (John), Singer, C.F., Casella, C, Singer, C.F. (Christian), Cassini, C.,, Askmalm, M.S. (Marie), Wijnen, J. T., Stenmark Askmalm, Marie,, Hogervorst, F B L,, D Stoppa-Lyonnet, Viel, A.,, Wang, X. (Xing), Spiess, E. (Eberhard), Nathanson, KL, Niederacher, D. (Dieter), Godwin, A.K., Heikkinen, T, Deiler, H. (H.), Verhoef, S., Varon-Mateeva, R., X Chen, H Nevanlinna, Andrulis, I.L., Caligo, M.A., Spiess, A-C, Johannsson, O. T., Lejbkowicz, F., Barile, M., Cohen, S, Sinilnikova, O. (Olga), Fricker, J-P,, Schmutzler, R.K., Olivier-Faivre, L., Goldgar, D. (David), Piedmonte, M. (Marion), Lalloo, F, Basil, J. (Jack), Terry, M B, Arnold, N. (Norbert), F B L Hogervorst, F. Boggess, J.,, Daly, M, Antoniou, A. C., Malmer, B., C. Antoniou, A., Cook, M, Beesley, J., Peock, S.,, Osorio, A. (Ana), B Versmold, Kaufman, B., Wakeley, K, Lynch, H. T., Cook, J, Szabo, C. (Csilla), Varon-Mateeva, R.,, Malmer, B.,, Pichert, G. (Gabriella), Cruger, D G,, Chenevix-Trench, G. (Georgia), R K Schmutzler, Peyrat, J-P, Easton, D F,, Kosarin, K, Oliver, C. T., Friedman, E. (Eitan), J L Hopper, Eeles, R. (Rosalind), Askmalm, MS, Lindor, N.M. (Noralane), Imyanitov, E N, de la Hoya, M, Hopper, J L,, Thomassen, M., Versmold, B. (Beatrix), Ouweland, A.M.W. van den, D G Cruger, Lalloo, F. (Fiona), Peyrat, J.-P., Gerdes, A. -M, Cajal, TRY, Zikan, M. (Michal), Montagna, M. (Marco), Easton, D.F. (Douglas), Lejbkowicz, F.,, Peock, S., Garcíla, E. B.Gómez, Weerasooriya, N., Cohen, S. (Shimrit), Morrison, P.J. (Patrick), Lejbkowicz, F, I L Andrulis, van den Ouweland, A, Ouweland, A. van den, Spurdle, A. B., Peock, S, Wijnen, J T, Hodgson, S, Révillion, F. (Françoise), L Olivier-Faivre, D F Easton, Gerdes, A.M., Luccarini, C., Radice, P. (Paolo), Wijnen, J.T. (Juul), Arver, B, Deissler, H, Domchek, S. M., HEBON, M Daly, M Zikan, V. Blank, S.,, Evans, D. G., Foretova, L. (Lenka), Osorio, A., Terry, M.-B. (Mary-Beth), Rodriguez, G.C., Radice, P., Buys, S.,, Gerdes, AM, Cook, M. (Margaret), Deiler, H., Wijnen, J T,, Cohen, S., Barile, M. (Monica), Frost, D. (Debra), Barnett-Griness, O. (Ofra), Godwin, A. K., T Kontorovich, D Goldgar, N Weerasooriya, Greene, M H,, McGuffog, L, K L Nathanson, G C Rodriguez, T. Johannsson, O., Nordling, Margareta,, Varon-Mateeva, R. (Raymonda), Lindor, N, Neuhausen, S L, Ding, Y.C. (Yuan), Singer, C. F., Spurdle, A.B. (Amanda), Schwartz, P. E., A Viel, C. Antoniou, A.,, Engel, C. (Christoph), Fricker, J.-P., Gschwantler-Kaulich, D, Barile, M.,, L Tizzoni +809 morecore +1 more sourceBRCA-deficient metastatic prostate cancer has an adverse prognosis and distinct genomic phenotypeResearch in context
EBioMedicine, 2023 Summary: Background: Genomic alterations in DNA damage response (DDR) genes are common in metastatic castration-resistant prostate cancer (mCRPC). Understanding how these genomic events impact prognosis and/or treatment response is vital for optimising ...Heidi Fettke, Chao Dai, Edmond M. Kwan, Tiantian Zheng, Pan Du, Nicole Ng, Patricia Bukczynska, Maria Docanto, Louise Kostos, Siavash Foroughi, Stephen Brown, Lisa-Jane K. Graham, Kate Mahon, Lisa G. Horvath, Shidong Jia, Manish Kohli, Arun A. Azad +16 moredoaj +1 more sourceBRCA2 and Smad3 synergize in regulation of gene transcription [PDF]
Oncogene, 2002 Smad3 is an essential component in the intracellular signaling of transforming growth factor-beta (TGFbeta), which is a potent inhibitor of tumor cell proliferation. BRCA2 is a tumor suppressor involved in early onset of breast, ovarian and prostate cancer. Both Smad3 and BRCA2 possess transcription activation domains.Olena, Preobrazhenska, Mariya, Yakymovych, Takashi, Kanamoto, Ihor, Yakymovych, Rostyslav, Stoika, Carl-Henrik, Heldin, Serhiy, Souchelnytskyi +6 moreopenaire +2 more sourcesHypersensitivity of BRCA1 heterozygote lymphoblastoid cells to gamma radiation and PARP inhibitors [PDF]
, 2013 This article is made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 Bourton EC, et al. This is an open-access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use ...Bourton, EC, Plowman, PN, Parris, C, Parris, CN, Foster, HA, Harvey, AJ +5 morecore +1 more source
