Results 51 to 60 of about 44,727 (269)
Germline variants in DNA repair genes associated with hereditary breast and ovarian cancer syndrome: analysis of a 21 gene panel in the Brazilian population
BMC Medical Genomics, 2020 Background The Hereditary Breast and Ovarian Cancer Syndrome (HBOC) occurs in families with a history of breast/ovarian cancer, presenting an autosomal dominant inheritance pattern.Simone da Costa e Silva Carvalho, Nathalia Moreno Cury, Danielle Barbosa Brotto, Luiza Ferreira de Araujo, Reginaldo Cruz Alves Rosa, Lorena Alves Texeira, Jessica Rodrigues Plaça, Adriana Aparecida Marques, Kamila Chagas Peronni, Patricia de Cássia Ruy, Greice Andreotti Molfetta, Julio Cesar Moriguti, Dirce Maria Carraro, Edenir Inêz Palmero, Patricia Ashton-Prolla, Victor Evangelista de Faria Ferraz, Wilson Araujo Silva Jr +16 moredoaj +1 more sourceMITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more sourceUK-based clinical testing programme for somatic and germline BRCA1/2, ATM and CDK12 mutations in prostate cancer: first results
BMJ OncologyObjective Germline BRCA2 pathogenic variants (PVs) are known to cause ~4% of prostate cancer, but other homologous repair genes, BRCA1, ATM, PALB2 and Lynch syndrome genes are also involved.Helene Schlecht, Emma R Woodward, D Gareth Evans, Fiona Lalloo, George Burghel, Ashwin Sachdeva, Andrew Hudson, Robert Bristow, Omi Parikh +8 moredoaj +1 more sourcePALB2 (partner and localizer of BRCA2) [PDF]
, 2018 PALB2 (Partner and Localizer of BRCA2) was first identified as a BRCA2-interacting protein. Subsequently, PALB2 has been recognized as a cog in the cellular machinery for DNA repair by homologous recombination (HR).Hanenberg, Helmut, Andreassen, Paul Rcore +1 more sourceInhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen +11 morewiley +1 more sourceCommon breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
, 2011 The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by ...Donaldson, A., Danièle Muller, Mark H Greene, L Mai, Phuong,, SWE-BRCA, Madeleine MA Tilanus Linthorst, Engel, C., Pankratz, Vernon, Murray, A, Muy-Kheng Tea, Barrowdale, D., Paul DP Pharoah, Wachenfeldt, v.A., Lynch, Henry, Maria A Caligo, Network, OCG, Wachenfeldt, A. (Anna) von, Anne Marie Gerdes, Boutry-Kryza, Nadia, Barkardottir, Rosa B, F Easton, Douglas,, Varon-Mateeva, Raymonda, Investigators, K, Tilanus-Linthorst, Madeleine M. A., Ozcelik, Hilmi, Pascal Pujol, Breast Canc Family Registry, Kast, K, Kets, C.M. (Marleen), Raymonda Varon Mateeva, Wachenfeldt, V., Martine Dumont, Ejlertsen, B. (Bent), Meindl, A., K Godwin, Andrew, Gschwantler-Kaulich, D. (Daphne), Viel, Alessandra, Meijers-Heijboer, Hanne E.J., Heli Nevanlinna, Patricia A. Ganz, de la Hoya, Miguel, Andrew K. Godwin, Couch, F.J. (Fergus), Skytte, Anne-Bine, Paolo Peterlongo, Janavicius, Ramunas,, Bonanni, Bernardo, Ana Osorio, John L Hopper, Viel, A., Y Karlan, Beth,, Arnold, N, Soller, M., Mai, P.L. (Phuong), Caldes, Trinidad,, Hopper, JL, Olopade, Olufunmilayo, Ruehl, Ina, Gross, J. (Jenny), Eason, J., Chung, Wendy K., Kirsten B. Moysich, A. C. Breast Cancer Family Registry Antoniou, Wachenfeldt, VA, Arver, Brita, A Ganz, Patricia, Pujol, P, Brita Arver, Niederacher, D, Hansen, Thomas V.O., Miguel de la Hoya, Radice, Paolo,, Mark Sherman, Rookus, Matti, Sherman, Mark, Berthet, Pascaline, Benitez, Javier,, Verheus, Martijn, François Cornelis, Godino, J, Neuhausen, S.L. (Susan), Douglas F. Easton, Mulligan, A.M., S Pankratz, Vernon, Osorio, A, Hardouin, A, Os, Theo V., Antonis C. Antoniou, Rebbeck, Timothy R, Esther M John, Mazoyer, S, Aittomäki, K., Evans, D.G. (Gareth), Blanco, I, Rosa B. Barkardottir, Benítez, J. (Javier), Lee, A, Papi, Laura, Muller, D, Gómez García, EB, Kirsten B Moysich, Deissler, Helmut,, van Os, Theo, Gordon Glendon, Lebrun, Marine, Michel Longy, Spurdle, Amanda B, Antoniou, Antonis, Frances P. O'Malley, Pujol, Pascal,, Greene, Mark H., Ganz, Patricia A, Cattaneo, E., Iván Muñoz-Repeto, Berthet, P., Daphne Gschwantler-Kaulich, Gross, Jenny, Henry T. Lynch, J Louise Jones, Susan L Neuhausen, Buys, Saundra M, Mortemousque, Isabelle, Coupier, Isabelle,, Pertesi, M, Fricker, J-P, Ignacio Blanco, Hansen, T.V., Donaldson, A, Peissel, Bernard,, Fredericksen, Z, Henriksson, K, Eeles, R., van Der Luijt, Rob, Niederacher, Dieter,, Hopper, J.L., Godwin, AK, Fassy-Colcombet, M. (Marion), Tilanus-Linthorst, Madeleine M.A., Schäfer, D., Eason, J. (Jacqueline), Peock, Susan,, Cornelis, F, Peterlongo, Paolo, Evans, D. Gareth; id_orcid, Glendon, Gordon,, Pharoah, P.D.P., Dieter Schäfer, Varon-Mateeva, R, Olopade, O.I., Kruse, Torben A, Ganz, P.A. (Patricia), Ros Eeles, Chung, W., Terry, Mary, Beattie, M., Leone, Melanie,, Montagna, M., Javier Godino, Robson, Mark,, Durán, M., Kruse, Torben A., Gregory, H, Noralane M. Lindor, Gadzicki, D., Lindor, Noralane M, Pankratz, Vernon S, Davidson, R., Fricker, Jean-Pierre, Soucy, Penny, Susan J. Ramus, Raymonda Varon-Mateeva, Berthet, P. (Pascaline), Jensen, Uffe, Birk, Tilanus-Linthorst, M.M.A. (Madeleine), Simard, J. (Jacques), Miron, Alexander F., Manoukian, S. (Siranoush), Julian Barwell, Kruse, T.A., Godino, J. (Javier), van Os, Theo,, Os, Theo van, Robson, Mark, Sue Healey, Frances P O'Malley, Gerdes, Anne-Marie, GEMO Study Collaborators, Madeleine MA Tilanus-Linthorst, Bonanni, Bernardo,, Singer, Christian, Caux-Moncoutier, V. (Virginie), Engel, Christoph, Tognazzo, Silvia,, Kauff, N. (Noah), Pertesi, Maroulio,, Torben A. Kruse, Adlard, Julian,, Aittomäki, K. (Kristiina), Sakr, R. (Rita), Ramunas Janavicius, Buys, SM, Ottini, Laura,, Schäfer, Dieter, Marie Stenmark-Askmalm, Soller, Maria,, Janavicius, R, Gevensleben, H, Heidrun Gevensleben, Rookus, M, Hansen, Thomas V., Godwin, Andrew K, Christian Sutter, Meindl, A, DAndrea, Emma,, Karlan, B.Y., Muy Kheng Tea, Sevenet, N., Mai, Phuong L, Toland, Amanda E, Dieter Niederacher, Caux-Moncoutier, V, Benítez, J., Wijnen, J., Muller, Danièle, Hamann, U. (Ute), Ottini, Laura, Moysich, Kirsten B., Gross, J, Madeleine M. A. Tilanus Linthorst, Iván Muñoz Repeto, E Side, Lucy, Susan J Ramus, Henry T Lynch, Arver, B. (Brita Wasteson), Muller, D.W. (Danièle), Isaacs, Claudine, Barrowdale, Daniel,, Esther M. John, Peterlongo, P, Southey, Melissa C., Fredericksen, Z., Hansen, Thomas vO., Olopade, Olufunmilayo I, Bhatia, Jasmine, Wijnen, J, Heinritz, W., Mai, PL, Ozcelik, H, Rosa B Barkardottir, Manoukian, S., Antoniou, A.C. (Antonis), Gerdes, Anne-Marie,, Peock, S. (Susan), Thomassen, M. (Mads), Gómez García, Encarna B., Domchek, SM, Daniel Barrowdale, Henriksson, Karin, Kientz, Caroline,, Caux-Moncoutier, Virginie, Gaudet, M., Kets, C Marleen,, Sevenet, Nicolas,, Kauff, N, Adlard, J.W. (Julian), Adlard, J, Lee, A. (Andrew), Mortemousque, Isabelle,, Easton, Douglas F., Melissa C Southey, Ruehl, I. (Ina), Léoné, Mélanie, Skytte, A.-B. (Anne-Bine), Emma McCann, Lebrun, M., Bernard Peissel, Andrulis, I.L. (Irene), Lazaro, C, Caligo, MA, Hanne EJ Meijers-Heijboer, Os, Theo v, Wang, X.S., Caux-Moncoutier, V., Houghton, C., Heikinen, T. (Tuomas), Jacqueline Eason, Deissler, H. (Helmut), Schmutzler, RK, Anne Bine Skytte, Gadzicki, D. (Dorothea), Saundra M. Buys, Donaldson, Alan,, Gerdes, A-M. (Anne-Marie), O'Malley, Frances, F Miron, Alexander,, Maria A. Caligo, Weitzel, JN, Seynaeve, C.M. (Caroline), Sutter, C., Pharoah, Paul D. P., Ozcelik, H. (Hilmi), Anne-Marie Gerdes, Helmut Deissler, Gaudet, Mia,, Finn C Nielsen, F Miron, Alexander, Garcia, E.B.G., Rookus, M., Eccles, Diana,, Coupier, I., Fassy-Colcombet, Marion, Caligo, Maria A, Toland, Amanda E., Penny Soucy, L Nathanson, Katherine, McCann, E., Mulligan, Anna Marie, Mads Thomassen, Spurdle, Amanda, Meindl, Alfons,, C Southey, Melissa,, Domchek, S.M., Deissler, H., Mazoyer, S., Eeles, Ros, McGuffog, L. (Lesley), Tea, Muy-Kheng, Preisler-Adams, Sabine,, Gadzicki, D, Fergus J Couch, Hansen, TV, Frost, D., Terry, MB, Marcel R Nelen, Vernon S Pankratz, Marion Fassy Colcombet, Os, T. van, Neuhausen, Susan, Hopper, John L., Hansen, TVO, B Barkardottir, Rosa,, Hamann, U, Conxi Lazaro, Schoenbuchner, Ines, Imyanitov, E., Antoniou, AC, Rosemarie Davidson, Isaacs, C., Wachenfeldt, von A, Soller, M, Pujol, Pascal, Davidson, R, Donaldson, Alan, Eason, Jacqueline,, Adlard, Julian, Offit, K, Sherman, M.E. (Mark), Donaldson, A. (Alan), Frost, D, Daly, Mary B, Schaefer, Dieter, Cook, J., Wang, XS, Wang, Xianshu, Ottini, L, Caligo, Maria, Peock, Susan, Hansen, Thomas v, Karlan, BY, Moysich, Kirsten B, Rhiem, K, Mazoyer, S. (Sylvie), E. M. John, Yan, M. (Max), Benitez, Javier, Boutry-Kryza, N, Muñoz-Repeto, I., Papi, L., Ontario Canc Genetics Network, Ding, Yuan,, Lee, A., Nielsen, FC, Luijt, R.B. (Rob) van der, Mary B. Daly, John, EM, Preisler-Adams, S. (Sabine), Barkardottir, R.B. (Rosa), Wachenfeldt, von Anna, Mulligan, AM, Sakr, R., Chung, W. (Wendy), Caldes, T. (Trinidad), Kientz, C, Nathanson, K.L. (Katherine), Izatt, Louise, Savarese, A., Pankratz, V.S. (Shane), Os, Theo, Rita K. Schmutzler, Wang, X, Muller, D., Sutter, C, Gadzicki, Dorothea,, Kientz, Caroline, Manoukian, Siranoush,, Ganz, P.A., Lalloo, F., Heikkinen, T., Alan Donaldson, Wang, Xianshu,, C Marleen Kets, Evans, D G, Mortemousque, I. (Isabelle), Houghton, Catherine,, Ontario Cancer Genetics Network, Adlard, J., Loris Bernard, Bhatia, Jasmine,, Os, Theo, Van, Hamann, Ute, Yan, Max, Cornelis, F. (Franco̧is), Fassy-Colcombet, M., E Tomlinson, Gail, Singer, Christian F, Kruse, T.A. (Torben), Norbert Arnold, Kets, C Marleen, Easton, Douglas, Jean Pierre Fricker, Godwin, A.K. (Andrew), McGuffog, L., Blanco, I., Peissel, Bernard, Stenmark-Askmalm, M., Schaefer, Dieter,, Sevenet, N. (Nicolas), Sevenet, N, Miron, A. (Alexander), P OMalley, Frances,, Radice, Paolo, Frost, Debra, Ganz, PA, van der Luijt, RB, Jeffrey N Weitzel, Fricker, J.P., Arnold, Norbert, L Andrulis, Irene,, Rebbeck, T, Kast, Karin, Pharoah, Paul DP, Ramus, S.J., Barkardottir, Rosa, Caldes, T., Daly, Mary B., Gregory, Helen,, Sakr, R, Murray, A., Miron, AF, Ruehl, Ina,, Sinilnikova, OM, Maroulio Pertesi, Jones, J Louise, Meijers-Heijboer, Hanne E, Fricker, Jean-Pierre,, Chun Ding, Yuan, Side, L.E., Boutry-Kryza, Nadia,, Ramus, Susan J, C. Marleen Kets, Noah Kauff, Ozcelik, H., Caroline Seynaeve, Trinidad Caldes, Daphne Gschwantler Kaulich, Soucy, Penny,, Stoppa-Lyonnet, D., Peterlongo, P. (Paolo), Munoz-Repeto, Ivan,, Rookus, M.A. (Matti), A Ganz, Patricia,, Soller, Maria, Side, Lucy E, Dorkins, H, Daly, M.B. (Mary), Henriksson, Karin,, D P Pharoah, Paul,, Glendon, Gordon, A Kruse, Torben,, van Os, T., Wijnen, Juul, McCann, Emma, H Greene, Mark, Karlsson, Per,, Karin Kast, Fredericksen, Z. (Zachary), Huw Dorkins, Caldes, T, Hoya, M. (Miguel) de La, Paul D. P. Pharoah, Alexander F. Miron, Cattaneo, Elisa, Stenmark-Askmalm, M, D P Pharoah, Paul, Gail E. Tomlinson, Susan M Domchek, Stoppa-Lyonnet, D, Tilanus-Linthorst, Madeleine M A, Peterlongo, P., Lázaro, C. (Conxi), Garcia, Encarna B. Gomez, Barwell, Julian, John, Esther, Greene, Mark H, Gevensleben, H. (Heidrun), Stoppa-Lyonnet, D. (Dominique), Bent Ejlertsen, Montagna, M, Beattie, Mary, Ejlertsen, B, Caux-Moncoutier, Virginie,, Viel, A. (Alessandra), Anneliese Fink-Retter, Peterlongo, Paolo,, Nelen, Marcel R, Encarna B Gómez García, Mulligan, Anna, Marie, Jackie Cook, Dumont, M., Neuhausen, Susan L, Terry, Mary, Beth, Karlsson, P., Lee, Andrew Roger, Barbara Wappenschmidt, Family Registry, Breast Cancer, Meindl, Alfons, Terry, Mary,, Neuhausen, S.L., L Neuhausen, Susan, Lazaro, Conxi, Ejlertsen, Bent,, Evgeny Imyanitov, Anna Marie Mulligan, Terry, Mary B., Soucy, P., Eason, J, Martijn Verheus, Tomlinson, Gail E, Arver, Brita,, Gevensleben, Heidrun, Heikkinen, Tuomas, Toland, Amanda, Isabelle Mortemousque, Tilanus-Linthorst, MMA, Dorkins, Huw, Healey, S, McCann, Emma,, Aittomäki, Kristiina, Heinritz, W. (Wolfram), Couch, Fergus, I Olopade, Olufunmilayo, Tognazzo, S., Tomlinson, G.E., EMBRACE, Dorothea Gadzicki, Hardouin, Agnès, Preisler-Adams, S., Toland, A.E., Greene, M.H., Karlan, Beth, Nevanlinna, H., Coupier, Isabelle, Hoya, M. de la, Nathanson, Katherine L, von Wachenfeldt, Anna, Pasini, B, Sutter, Christian,, A Caligo, Maria,, McGuffog, Lesley, Lazaro, C (Conxi), Fink-Retter, A. (Anneliese), Hilmi Ozcelik, Collaborators, GEMOS, Pharoah, Paul D P, Lee, Andrew, Sakr, Rita, Jensen, UB, Simard, Jacques,, Chung, Wendy,, Ruehl, I., Mazoyer, Sylvie, Christian F. Singer, Olga M Sinilnikova, B Barkardottir, Rosa, Hopper, John, Jones, J L, Schmutzler, Rita, Antoniou, A.C., Heikkinen, Tuomas,, Claudine Isaacs, Boutry-Kryza, N., M Buys, Saundra, Singer, CF, Papi, Laura,, Ding, Yuan C., Hardouin, Agnes,, Blanco, Ignacio, Lynch, Henry T., Mulligan, Anna,, Chun Ding, Yuan,, Ottini, L. (Laura), Andrulis, IL, Fricker, J.P. (Jean Pierre), Susan M. Domchek, Breast Cancer Family Registry, Pankratz, VS, Sherman, M, Stenmark Askmalm, Marie, Lynch, H.T., Side, L. (Lucy), Lazaro, Conxi,, Meijers-Heijboer, E.J. (Hanne), Goldgar, D., Nathanson, Katherine, Tea, Muy Kheng, Aittomaki, Kristiina,, McCann, E. (Emma), Karlan, B.Y. (Beth), Siranoush Manoukian, Nevanlinna, H, Ramus, Susan, Nelen, MR, Schoenbuchner, I., Terry, Mary B, Pascaline Berthet, Caligo, M.A. (Maria), Goldgar, D, Mark H. Greene, Ramus, Susan J., Nevanlinna, H. (Heli), Sylvie Mazoyer, Fink-Retter, A., Meijers-Heijboer, Hanne E J, Hanne E. J. Meijers Heijboer, Ramus, Susan J,, Moysich, Kirsten, Zaffaroni, Daniela, Kets, C.M., Pankratz, V.S., Preisler-Adams, Sabine, Seynaeve, C, Katherine L Nathanson, Hansen, Thomas V O, Simard, J., Easton, D.F., Nelen, Marcel, Sabine Preisler-Adams, Per Karlsson, Bernard, L, Godwin, Andrew K., Jensen, Uffe,, Mary Beth Terry, Radice, P, Gevensleben, Heidrun,, Jones, J.L. (J Louise), Weitzel, J.N. (Jeffrey), F Singer, Christian,, Weitzel, J.N., B Daly, Mary,, Chenevix-Trench, G., Daly, Mary, Sinilnikova, O.M., Terry, Mary Beth, Ding, Y.C., Glendon, G, Hansen, T.V.O. (Thomas), Virginie Caux Moncoutier, Lucy E. Side, Marie Stenmark Askmalm, Lazaro, C., Hansen, Thomas V. O., kConFab Investigators, Imyanitov, E, Montagna, Marco,, Christoph Engel, F Easton, Douglas, Skytte, Anne Bine, Moysich, K.B. (Kirsten), Healey, S. (Sue), Seynaeve, C., Fox, S.B. (Stephen), Bernard, Loris, Kauff, N., van der Luijt, Rob B., Beth Terry, Mary,, Couch, Fergus J, Mai, Phuong, Lebrun, M. (Marine), van der Luijt, Rob B,, Garcia, EBG, Barkardottir, Rosa B., Andrulis, Irene L, Alex Murray, Kristiina Aittomäki, Ganz, Patricia, Olga M. Sinilnikova, Wappenschmidt, B, Fiebig, B. (Britta), Zachary Fredericksen, Max Yan, Niederacher, D., H Greene, Mark,, Fricker, JP, Side, Lucy, Mia Gaudet, Fassy-Colcombet, Marion,, A Caligo, Maria, DAndrea, Emma, Greene, MH, Pujol, P. (Pascal), Pharoah, Paul D, Frost, Debra,, Karlan, Beth Y, Saundra M Buys, van der Luijt, R.B., Yan, M, Kauff, Noah,, Soller, M. (Maria), Tilanus-Linthorst, M.M.A., Verheus, M, Beth Terry, Mary, Georgia Chenevix-Trench, Osorio, Ana, Greene, M.H. (Mark), Offit, Kenneth, Houghton, C. (Catherine), T Lynch, Henry,, Nielsen, Finn, de Al Hoya, Miguel, M Lindor, Noralane,, Ozcelik, Hilmi,, Debra Frost, Agnès Hardouin, Barwell, J., Varon-Mateeva, Raymonda,, M Buys, Saundra,, Miron, A.F., Jones, JL, Thomas vO Hansen, Pharoah, Paul D.P., Jensen, Uffe B, Southey, Melissa, Janavicius, Ramunas, Lynch, H. (Henry), Barrowdale, D, O'Malley, F.P., Beattie, M, L Hopper, John,, de la Hoya, M., Spurdle, Amanda B,, Spurdle, Amanda B., Kast, K., Rob B van der Luijt, Tea, Muy-Kheng,, Heinritz, W, Nielsen, Finn C, Evans, D Gareth, Bonanni, B, Spurdle, AB, Greene, Mark, Soucy, P, van Os, T, Lynch, HT, Bernard, Loris,, Melissa C. Southey, Domchek, S.M. (Susan), Diana Eccles, Os, Theo,, Alexander F Miron, Olufunmilayo I. Olopade, Jasmine Bhatia, Moysich, K.B., Tomlinson, Gail E., Evans, DG, John, E.M. (Esther), Davidson, Rosemarie,, B Moysich, Kirsten, Jones, J. Louise, Rebbeck, Tim,, Gómez García, E.B., Hamann, Ute,, Rebbeck, Tim, Peissel, B. (Bernard), Neuhausen, Susan L., Savarese, A, Jeffrey N. Weitzel, K Godwin, Andrew,, Olufunmilayo I Olopade, Isaacs, C. (Claudine), Fink-Retter, Anneliese, Cattaneo, Elisa,, Davidson, R. (Rosemarie), Gomez Garcia, EncarnaB,, Isabelle Coupier, Yan, Max,, Fiebig, B, Engel, Christoph,, Schaefer, D, P OMalley, Frances, Lesley McGuffog, Olopade, Olufunmilayo I., K Schmutzler, Rita, Offit, Kenneth,, Antoniou, Antonis C, Longy, M., Munoz-Repeto, I, Kientz, C., Andrew K Godwin, T Lynch, Henry, Phuong L. Mai, Amanda E. Toland, Eccles, D., Pasini, B., Zaffaroni, D., Britta Fiebig, Thomassen, Mads,, Fox, Stephen,, Fox, S., Katherine L. Nathanson, Mazoyer, Sylvie,, Fiebig, Britta, Lynch, Henry T, Gross, Jenny,, Sherman, M., Gerdes, A.-M., Thomassen, Mads, Meijers-Heijboer, HEJ, Side, Lucy E., Tilanus-Linthorst, Madeleine, Jones, J Louise,, Kruse, TA, Bhatia, J., Preisler-Adams, S, Barbara Pasini, CIMBA, Weitzel, Jeffrey N, Anna Wachenfeldt, von, Rebbeck, T., Thomas V. O. Hansen, Kenneth Offit, Mai, P.L., Yuan Ding, Evans, D. Gareth, A Kruse, Torben, Gomez Garcia, EncarnaB, Noralane M Lindor, Sakr, Rita,, Imyanitov, E.N. (Evgeny), Eccles, D, Schmutzler, R.K. (Rita), Kets, C. Marleen, Rob B. van der Luijt, Fink-Retter, Anneliese,, Kets, C M, Murray, Alex,, M John, Esther,, Nathanson, K.L., Robson, M., Easton, Douglas F, Gómez García, Encarna, Emma D'Andrea, Chung, W, Coupier, I. (Isabelle), Stenmark-Askmalm, M. (M.), Christian F Singer, Niederacher, Dieter, Chenevix-Trench, G, Marine Lebrun, Zaffaroni, Daniela,, Arver, B., Schoenbuchner, I. (Ines), Moysich, KB, Ruehl, I, Marion Fassy-Colcombet, Tognazzo, S. (Silvia), Mulligan, Anna Marie,, Rhiem, K. (Kerstin), Jensen, Uffe B., McGuffog, Lesley,, Eeles, Ros,, Hansen, Thomas vO, Anna Wachenfeldt, von,, C Antoniou, Antonis,, Lund University., van Wijnen, J (Juul), D. Gareth Evans, Dominique Stoppa Lyonnet, Domchek, Susan M., Pankratz, Vernon S., Marcel R. Nelen, Offit, K., Couch, FJ, Domchek, Susan M,, Evans, D.G., Jensen, Uffe, Meijers-Heijboer, Hanne EJ, Dorkins, H. (Huw), Eeles, R, Nevanlinna, Heli, Ina Ruehl, Cook, Jackie, Schäfer, D, Dorkins, Huw,, Leone, M, Healey, S., John L. Hopper, Jacques Simard, Mary Beattie, B Moysich, Kirsten,, Wendy Chung, Savarese, A. (Antonella), Buys, Saundra M., Engel, C, Peissel, B., Meijers-Heijboer, Hanne, Simard, Jacques, C Antoniou, Antonis, Buys, S.M., S Pankratz, Vernon,, Sutter, C. (Christian), Toland, A.E. (Amanda), Verheus, M. (Martijn), Blanco, Ignacio,, Glendon, G., Y Karlan, Beth, Ding, Yuan, Bhatia, J, L Hopper, John, Stenmark-Askmalm, Marie, Louise Izatt, Szabo, Csilla, O'Malley, F.P. (Frances), L Neuhausen, Susan,, Sabine Preisler Adams, Wolfram Heinritz, Glendon, G. (Gord), Hardouin, A. (Agnès), Amanda E Toland, Nevanlinna, Heli,, Tuomas Heikkinen, Izatt, Louise,, Couch, Fergus J., Lindor, N.M., Couch, Fergus J,, Ramus, SJ, Benitez, J, Pertesi, M. (Maroulio), J. Louise Jones, Helen Gregory, Mulligan, Anna M, Houghton, C, Szabo, C, Kientz, C. (Caroline), Tilanus-Linthorst, Madeleine M A,, Couch, F.J., Izatt, L. (Louise), Nadia Boutry-Kryza, Skytte, Anne-Bine,, Jenny Gross, Montagna, Marco, Hamann, U., Duran, M, Tilanus - Linthorst, Madeleine, Ding, Yuan C, Toland, AE, Douglas F Easton, Rookus, Matti,, Pasini, B. (Barbara), Wang, X., Chenevix-Trench, Georgia,, Coupier, I, Szabo, C., Matti Rookus, Theo Os, Irene L Andrulis, Mulligan, Anna, Daly, MB, Eason, Jacqueline, Aittomaki, K, Tognazzo, S, Karlan, Beth Y., Dumont, Martine,, Verheus, M., Léone, M. (Mélanie), Godino, Javier, Laura Ottini, Hansen, Thomas V O,, Weitzel, Jeffrey N., Buys, S.S. (Saundra), Izatt, L. +999 morecore +1 more sourceHarnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma
Advanced Science, EarlyView.MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu +21 morewiley +1 more source
