Gene Expression Dominance in Allopolyploids: Hypotheses and Models [PDF]
Trends in Plant Science, 2018 The classical example of nonadditive contributions of the two parents to allopolyploids is nucleolar dominance, which entails silencing of one parental set of ribosomal RNA genes. This has been observed for many other loci. The prevailing explanation for this genome-wide expression disparity is that the two merged genomes differ in their transposable ...
Bottani, S +3 more
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Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Nature, 2017 Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with the acquisition of large copy number variants that provide mutated cells with
F. Merkle +16 more
semanticscholar +1 more source
Oakleaf: an S locus-linked mutation of Primula vulgaris that affects leaf and flower development [PDF]
, 2015 •In Primula vulgaris outcrossing is promoted through reciprocal herkogamy with insect-mediated cross-pollination between pin and thrum form flowers. Development of heteromorphic flowers is coordinated by genes at the S locus.
Anders S +19 more
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The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank
Scientific Reports, 2023 We recently devised continuous “sex-scores” that sum up multiple quantitative traits, weighted by their respective sex-difference effect sizes, as an approach to estimating polyphenotypic “maleness/femaleness” within each binary sex.
Daniel E. Vosberg +2 more
doaj +1 more source
Germline Mutations in Predisposition Genes in Pediatric Cancer.
New England Journal of Medicine, 2015 BACKGROUND The prevalence and spectrum of predisposing mutations among children and adolescents with cancer are largely unknown. Knowledge of such mutations may improve the understanding of tumorigenesis, direct patient care, and enable genetic ...
Jinghui Zhang +31 more
semanticscholar +1 more source
Acta Scientiarum: Agronomy, 2016 Mixed inheritance analysis using joint segregation analysis (JSA) for stripe rust (Puccinia striiformis f. sp. tritici) resistance was carried out in six basic populations (P1, F1, P2, BC1, BC2 and F2) of four wheat crosses (Hashim-08 × LU-26, Farid-06 ×
Kalim Ullah +5 more
doaj +1 more source
Genetic Complexity of Autosomal Dominant Polycystic Kidney and Liver Diseases.
Journal of the American Society of Nephrology, 2017 Data indicate significant phenotypic and genotypic overlap, plus a common pathogenesis, between two groups of inherited disorders, autosomal dominant polycystic kidney diseases (ADPKD), a significant cause of ESRD, and autosomal dominant polycystic liver
E. Cornec-Le Gall, V. Torres, P. Harris
semanticscholar +1 more source
Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS) [PDF]
, 2012 Background: The pir genes comprise the largest multi-gene family in Plasmodium, with members found in P. vivax, P. knowlesi and the rodent malaria species.
Berriman, Matthew +11 more
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Genetic Analysis on Seed Size of Chieh-qua by Mixture Model of Major Genes and Polygenes
Guangdong nongye kexue, 2023 【Objective】Genetic analysis of major gene and polygenes was conducted on the length, width, and quality of Chieh-qua seeds to study the genetic rules of seed size and select high-quality Chieh-qua varieties.【Method】Chieh-qua inbred line J16 (big seed ...
Yin GAO +3 more
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Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]
, 2014 Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C +8 more
core +1 more source