Genetic interactions reveal the evolutionary trajectories of duplicate genes
Molecular Systems Biology, 2010 The characterization of functional redundancy and divergence between duplicate genes is an important step in understanding the evolution of genetic systems.
Benjamin VanderSluis +9 more
doaj +2 more sources
Extensive copy-number variation of young genes across stickleback populations. [PDF]
PLoS Genetics, 2014 Duplicate genes emerge as copy-number variations (CNVs) at the population level, and remain copy-number polymorphic until they are fixed or lost. The successful establishment of such structural polymorphisms in the genome plays an important role in ...
Frédéric J J Chain +10 more
doaj +1 more source
On the origins of Mendelian disease genes in man: the impact of gene duplication [PDF]
, 2011 Over 3,000 human diseases are known to be linked to heritable genetic variation, mapping to over 1,700 unique genes. Dating of the evolutionary age of these disease-associated genes has suggested that they have a tendency to be ancient, specifically ...
Dickerson, Jonathan E. +1 more
core +1 more source
Role of duplicate genes in robustness against deleterious human mutations. [PDF]
PLoS Genetics, 2008 It is now widely recognized that robustness is an inherent property of biological systems [1],[2],[3]. The contribution of close sequence homologs to genetic robustness against null mutations has been previously demonstrated in simple organisms [4],[5 ...
Tzu-Lin Hsiao, Dennis Vitkup
doaj +1 more source
The evolution of gene duplicates in angiosperms and the impact of protein-protein interactions and the mechanism of duplication [PDF]
, 2019 Gene duplicates, generated through either whole genome duplication (WGD) or small-scale duplication (SSD), are prominent in angiosperms and are believed to play an important role in adaptation and in generating evolutionary novelty.
Carretero-Paulet, Lorenzo +2 more
core +2 more sources
Target enrichment using parallel nanoliter quantitative PCR amplification [PDF]
, 2014 Background: Next generation targeted resequencing is replacing Sanger sequencing at high pace in routine genetic diagnosis. The need for well validated, high quality enrichment platforms to complement the bench-top next generation sequencing devices is ...
De Wilde, Bram +7 more
core +2 more sources
Recombination facilitates neofunctionalization of duplicate genes via originalization
BMC Genetics, 2010 Background Recently originalization was proposed to be an effective way of duplicate-gene preservation, in which recombination provokes the high frequency of original (or wild-type) allele on both duplicated loci.
Huang Ren +3 more
doaj +1 more source
Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]
, 2018 Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M. +5 more
core +1 more source
Multi-Omic Profiling of Melophlus Sponges Reveals Diverse Metabolomic and Microbiome Architectures that Are Non-overlapping with Ecological Neighbors. [PDF]
, 2020 Marine sponge holobionts, defined as filter-feeding sponge hosts together with their associated microbiomes, are prolific sources of natural products. The inventory of natural products that have been isolated from marine sponges is extensive. Here, using
Agarwal, Vinayak +5 more
core +2 more sources
Genetics and Molecular Biology, 2008 While it remains a matter of some debate, rapid sequence evolution of the coding sequences of duplicate genes is characteristic for early phases past duplication, but long established duplicates generally evolve under constraint, much like the rest of ...
Michael H. Kohn
doaj +1 more source