Evolution of stress-regulated gene expression in duplicate genes of Arabidopsis thaliana. [PDF]
PLoS Genetics, 2009 Due to the selection pressure imposed by highly variable environmental conditions, stress sensing and regulatory response mechanisms in plants are expected to evolve rapidly.
Cheng Zou +3 more
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Duplicate Genes Contribute to Variability in Abiotic Stress Resistance in Allopolyploid Wheat
Plants, 2023 Gene duplication is a universal biological phenomenon that drives genomic variation and diversity, plays a crucial role in plant evolution, and contributes to innovations in genetic engineering and crop development.
Linying Du, Zhenbing Ma, Hude Mao
doaj +1 more source
PLoS Genetics, 2013 When a duplicate gene has no apparent loss-of-function phenotype, it is commonly considered that the phenotype has been masked as a result of functional redundancy with the remaining paralog. This is supported by indirect evidence showing that multi-copy
Shane Woods +8 more
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Role of duplicate genes in determining the tissue-selectivity of hereditary diseases. [PDF]
PLoS Genetics, 2018 A longstanding puzzle in human genetics is what limits the clinical manifestation of hundreds of hereditary diseases to certain tissues, while their causal genes are expressed throughout the human body.
Ruth Barshir +5 more
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Endothelin-1 Drives Epithelial-Mesenchymal Transition In Hypertensive Nephroangiosclerosis [PDF]
, 2016 BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney.
Belloni, Anna S +13 more
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Gene duplication and evolution in recurring polyploidization–diploidization cycles in plants
Genome Biology, 2019 Background The sharp increase of plant genome and transcriptome data provide valuable resources to investigate evolutionary consequences of gene duplication in a range of taxa, and unravel common principles underlying duplicate gene retention. Results We
Xin Qiao +7 more
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A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes. [PDF]
PLoS Genetics, 2010 Gene duplication is supposed to be the major source for genetic innovations. However, how a new duplicate gene acquires functions by integrating into a pathway and results in adaptively important phenotypes has remained largely unknown.
Yun Ding +11 more
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An overview of online resources for intra-species detection of gene duplications
Frontiers in Genetics, 2022 Gene duplication plays an important role in evolutionary mechanism, which can act as a new source of genetic material in genome evolution. However, detecting duplicate genes from genomic data can be challenging. Various bioinformatics resources have been
Xi Zhang, Xi Zhang, David Roy Smith
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Loss of redundant gene expression after polyploidization in plants
, 1978 Based on chromosomal location data of genes encoding 28 biochemical systems in allohexaploid wheat,Triticum aestivum L. (genomes AABBDD), it is concluded that the proportions of systems controlled by triplicate, duplicate, and single loci are 57%, 25 ...
C. Aragoncillo +20 more
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The fate of Arabidopsis thaliana homeologous CNSs and their motifs in the Paleohexaploid Brassica rapa. [PDF]
, 2013 Following polyploidy, duplicate genes are often deleted, and if they are not, then duplicate regulatory regions are sometimes lost. By what mechanism is this loss and what is the chance that such a loss removes function?
Freeling, Michael +3 more
core +2 more sources