Results 241 to 250 of about 142,631 (286)

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Phenotypic and Molecular Analysis of Fosfomycin Resistance Among <i>P. aeruginosa</i> Isolates from Cystic Fibrosis Patients. [PDF]

Infect Drug Resist
Poormehr P, Behzadi A, Talebi Ahoi M, Khanbabaee G, Hakemi-Vala M.   +4 more
europepmc   +1 more source

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, EarlyView.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies. [PDF]

Bone Res
de Molon RS, Vernal R, Oliveira GE, Steffens JP, Ervolino E, Theodoro LH, van den Beucken JJJP, Tetradis S.   +7 more
europepmc   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, EarlyView.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions. [PDF]

Nat Commun
Alaiz-Noya M, Miozzo F, Fuentes-Ramos M, Machnicka MA, Kurowska M, Herrera ML, Del Blanco B, Ninerola S, Bustos-Martínez I, Wilczynski B, Barco A.   +10 more
europepmc   +1 more source

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

In-Silico discovery of Pediatric Acute-Myeloid-Leukemia (pAML) causing druggable molecular signatures highlighting their pathogenetic processes and therapeutic agents through single-cell RNA-Seq profile analysis. [PDF]

PLoS One
Ahmed MF, Al Noman M, Ahmed MF, Latif MA, Pappu MAA, Islam MS, Hossain MS, Hossen MB, Faysal MF, Hasan MM, Mollah MNH.   +10 more
europepmc   +1 more source

L-Quebrachitol Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption in Ovariectomized Rat Model. [PDF]

Biomolecules
Rattajak P, Aroonkesorn A, Yodthong T, Issuriya A, Maskaew S, Smythe C, Wititsuwannakul R, Pitakpornpreecha T.   +7 more
europepmc   +1 more source

Ototoxicity-induced c-Fos activation underlies the regenerative capacity of the vestibular sensory epithelia. [PDF]

Cell Commun Signal
Zhang Y, You D, Che C, Wang X, Li H, Tang YQ, Sun S.   +6 more
europepmc   +1 more source