Results 191 to 200 of about 2,522,112 (307)

MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih, Issam Tout, Najwa Ahmad Doha, Tala Abu Arja, Idris Mohammed, Doua Abdelrhaman, Waseem Hasan, Chadi Saad, Hamdi Mbarek, Borbala Mifsud, Sahar Isa Da'as   +10 more
wiley   +1 more source

Gene Expression Dynamics in <i>Monilinia fructicola</i> and <i>Prunus persica</i> During the Battle for Infection Revealed by Dual RNA-Seq Analysis. [PDF]

J Fungi (Basel)
Di Cosmo D, Franco MEE, Crudele M, Gerin D, Landi L, Pollastro S, Faretra F, De Miccolis Angelini RM.   +7 more
europepmc   +1 more source

Organ‐Resolved Host Proteomic and Post‐Translational Modification Landscapes in a Mouse Model of Talaromyces marneffei Infection

iMetaMed, EarlyView.
We presented an organ‐resolved, multiple PTM remodeling atlas of systemic T. marneffei infection, integrating quantitative proteome, phosphoproteome, ubiquitinome, acetylome, and lactylome data across the liver, lung, and spleen. The atlas delineated organ‐specific PTM signatures and a functional convergence of divergent modification types on immune ...
Wudi Wei, Shiyi Lai, Xiaotao He, Xiaoting Wei, Xiaoting Xie, Weihong Huang, Baili Zhan, Meng Zhang, Zongxiang Yuan, Rongfeng Chen, Jingzhen Lai, Yuyuan Huang, Kang Li, Sanqi An, Li Ye, Hao Liang, Junjun Jiang   +16 more
wiley   +1 more source

Virulence determinants of Fusarium oxysporum for clinical infections. [PDF]

PLoS Pathog
Coleman JJ, Shlezinger N, Ma LJ.
europepmc   +1 more source

Cross species metabolic complementation of vitamin K2 biosynthesis determines emergent suppression of tomato Fusarium wilt

iMeta, EarlyView.
Multi‐omics approaches have revealed a cross‐species functional emergence phenomenon leading to emergent suppression of Fusarium wilt. We show that a three‑species consortium exhibits emergent suppression of Fusarium oxysporum f. sp. lycopersici (Fol) that is absent in single or pairwise cultures.
Lizhi Zhao, Yuhui Li, Jianning Zhao, Alexandre Jousset, Francisco Dini‐Andreote, Lu Tan, Xiujing Guan, Yan Xu, Zhong Wei   +8 more
wiley   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Warming and Nitrogen Addition Induce Asynchronous Taxonomic and Functional Responses and Reorganize Microbial C, N, P Cycling Potential in an Alpine Wetland on the Qinghai-Tibet Plateau. [PDF]

Microorganisms
Chang W, Ma W, Du J, He W, Zhu N.
europepmc   +1 more source

Looking at Soil as It Is: Evolution of Microscopic Soil Characterization From Kubiëna to Artificial Intelligence

Journal of Plant Nutrition and Soil Science, EarlyView.
We provide a historic overview of microscopic soil structure characterization from its founding father, Walter Kubiëna, to several technical revolutions like automation, digitalization, and artificial intelligence. In addition to technical advancements, we explore how concepts and research questions have evolved in time.
Steffen Schlüter, Maik Geers‐Lucas, Peter Kühn, Hans‐Jörg Vogel   +3 more
wiley   +1 more source

Antifungal resistance landscapes in major fungal pathogens in Zhejiang, China. [PDF]

Fungal Biol Biotechnol
Wang H, Zhang J, Zhang N, Ji Y, Hong X, Sámano-Sánchez H, Xu F, Han Y, Xiong X, Welburn SC, Schulze H, Bachmann TT, Ge Y, Scharf DH.   +13 more
europepmc   +1 more source

Perspectives of High‐Resolution Mass Spectrometry in Soil Science

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has evolved into a transformative tool for unraveling the complex chemical ...
Bruno Glaser, Tobias Bromm, Klaus Kaiser, Arthur Gross, Carsten Simon, Snežana Maletić, Ines Mulder, Oliver J. Lechtenfeld, Sören Thiele‐Bruhn, Ivy Notterpek, Callum Banfield, Michaela A. Dippold   +11 more
wiley   +1 more source