Results 81 to 90 of about 5,097,692 (293)

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Structure and expression of fungal calmodulin gene

Journal of Biological Chemistry, 1989
I report on the isolation, structural analysis, and in vivo expression patterns of a fungal calmodulin gene. The gene is intronless and encodes a protein of 148 amino acid residues that is 92% homologous with vertebrate calmodulins. Through S1 nuclease transcript mapping, it was determined that the cloned gene (a) is transcribed in vivo, (b) has a 5 ...
openaire   +3 more sources

The filamentous fungal gene expression database (FFGED) [PDF]

Fungal Genetics and Biology, 2010
Filamentous fungal gene expression assays provide essential information for understanding systemic cellular regulation. To aid research on fungal gene expression, we constructed a novel, comprehensive, free database, the filamentous fungal gene expression database (FFGED), available at http://bioinfo.townsend.yale.edu.
Jeffrey P. Townsend, Zhang Zhang
openaire   +3 more sources

Studying fungal pathogens of humans and fungal infections: fungal diversity and diversity of approaches

Genes and Immunity, 2019
Seminal work by Louis Pasteur revealed the contribution of fungi—yeasts and microsporidia to agroindustry and disease in animals, respectively. More than 150 years later, the impact of fungi on human health and beyond is an ever-increasing issue ...
G. Janbon, J. Quintin, F. Lanternier, C. d’Enfert   +3 more
semanticscholar   +1 more source

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

Moving beyond species: fungal function in house dust provides novel targets for potential indicators of mold growth in homes

Microbiome
Background Increased risk of asthma and other respiratory diseases is associated with exposures to microbial communities growing in damp and moldy indoor environments.
Neeraja Balasubrahmaniam, Jon C. King, Bridget Hegarty, Karen C. Dannemiller   +3 more
doaj   +1 more source

Reference genes for gene expression analysis in the fungal pathogen Neonectria ditissima and their use demonstrating expression up-regulation of candidate virulence genes.

PLoS ONE, 2020
European canker, caused by the necrotrophic fungal phytopathogen Neonectria ditissima, is one of the most damaging apple diseases worldwide. An understanding of the molecular basis of N. ditissima virulence is currently lacking.
Liz M Florez, Reiny W A Scheper, Brent M Fisher, Paul W Sutherland, Matthew D Templeton, Joanna K Bowen   +5 more
doaj   +1 more source

Fungal virulence genes as targets for antifungal chemotherapy [PDF]

Antimicrobial Agents and Chemotherapy, 1996
Fungal virulence genes have now met the age of molecular pathogenesis. The definition of virulence genes needs to be broad so that it encompasses the focus on molecular antifungal targets and vaccine epitopes. However, in the broad but simple definition of a virulence gene, there will be many complex genetic and host interactions which investigators ...
openaire   +3 more sources

HEx: A heterologous expression platform for the discovery of fungal natural products

Science Advances, 2018
We develop a novel synthetic biology platform for rapid, scalable expression of fungal biosynthetic genes and encoded metabolites. For decades, fungi have been a source of U.S.
Colin J. B. Harvey, Mancheng Tang, U. Schlecht, J. Horecka, Curt R. Fischer, Hsiao‐Ching Lin, Jian Li, Brian T. Naughton, J. Cherry, Molly Miranda, Y. F. Li, A. Chu, James R. Hennessy, G. Vandova, Diane O. Inglis, Raeka S. Aiyar, L. Steinmetz, Ronald W. Davis, M. Medema, Elizabeth S. Sattely, C. Khosla, Robert P. St. Onge, Yi Tang, Maureen Hillenmeyer   +23 more
semanticscholar   +1 more source

GbSER02 Interacts With GhVOZ1 to Promote Fiber Elongation by Modulating Gibberellin Synthesis in Cotton

Advanced Science, EarlyView.
GbSER02 with a single base change (SNP517G) encodes normal serpin protein and interacts with transcription factor VOZ1 to alleviate the repression of VOZ1 on GA3ox1 and promote GA3 biosynthesis. Further, GA3 induces the expression of cell wall loosening‐related genes and decreases flavonoid content, ultimately facilitating fiber cell elongation in ...
Hao Jia, Dongmei Zhang, Qishen Gu, Yanbin Li, Jing Li, Wannian Li, Zhengwen Sun, Huifeng Ke, Jun Yang, Liqiang Wu, Yan Zhang, Zhiying Ma, Xingfen Wang   +12 more
wiley   +1 more source