Results 51 to 60 of about 23,322 (214)

Genes associated with alternatively activated macrophages discretely regulate helminth infection and pathogenesis in experimental mouse models

Immunobiology, 2010
Resolution of helminth infections is typically associated with the host launching a TH2 dominated immune response. In experimental models of helminth infections a key feature of this TH2 immunity is the induction of alternatively activated macrophage (AAM) populations.
Frank Brombacher, Frank Brombacher, William G. C. Horsnell   +2 more
openaire   +3 more sources

Temporal Changes in Total Serum Immunoglobulin E Levels in East German Children and the Effect of Potential Predictors [PDF]

, 2011
Background: Elevated total serum immunoglobulin E (IgE) levels are a prominent feature of allergic and parasitic diseases. An epidemiologic study was conducted in East German children to describe trends in the development of total serum IgE levels and ...
Brüske, Irene, Flohrs, Katrin, Heinrich, Joachim, Rzehak, Peter, Thiering, Elisabeth, Wichmann, Heinz-Erich   +5 more
core   +1 more source

Reference Intervals of Hematological Parameters Among Healthy Adults in Northern Sudan: A Community‐Based Cross‐Sectional Study

Journal of Clinical Laboratory Analysis, EarlyView.
Two hundred fifty‐three adults were enrolled in a cross‐sectional study conducted in Northern Sudan. The RVs of hemoglobin 9.71–16.10 g/dL, red blood cells (RBC) 3.66–5.79 × 106/mm3, hematocrit (HCT) 28.02%–46.75%, mean corpuscular volume (MCV) 64.02–95.65 fL, mean corpuscular hemoglobin (MCH) 21.57–33.80 pg, mean corpuscular hemoglobin concentration ...
Mohamed F. Lutfi, Ahmed Ali Hassan, Ishag Adam   +2 more
wiley   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation [PDF]

, 2015
We thank Manuel Kulagin for technical help, Pierre Bonnaventure for portal vein blood sampling, Francisco Sepulveda for technical assistance in GS-MS acquisition, and Dorothee Hahne (Metabolomics Australia, University of Western Australia) for human ...
Croese, John, Dubey, Lalit Kumar, Geldhof, Peter, Giacomin, Paul R, Harris, Nicola L, Junt, Tobias, Lebon, Luc, Loukas, Alex, Macpherson, Andrew J, Marsland, Benjamin J, McCoy, Kathleen D, Menin, Laure, Mosconi, Ilaria, Paerewijck, Oonagh, Piersigilli, Alessandra, Rapin, Alexis, Rougemont, Jacques, Sarter, Kerstin, Walker, Alan W, Zaiss, Mario M   +19 more
core   +4 more sources

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Schistosomes cause more mortality and morbidity than any other human helminth, but control primarily relies on a single drug that kills adult worms.
Geoffrey N Gobert, Mai H Tran, Luke Moertel, Jason Mulvenna, Malcolm K Jones, Donald P McManus, Alex Loukas   +6 more
doaj   +1 more source

Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation [PDF]

, 2016
Immunological cross talk between mucosal tissues such as the intestine and the lung is poorly defined during homeostasis and disease. Here, we show that a low-dose infection with the intestinally restricted helminth parasite Trichuris muris results in ...
Antignano, Frann, Burrows, Kyle, Chenery, Alistair L., Perona-Wright, Georgia, Scheer, Sebastian, Zaph, Colby   +5 more
core   +2 more sources

Forging a New Frontier: Antimicrobial Peptides and Nanotechnology Converging to Conquer Gastrointestinal Pathogens

Small, EarlyView.
This review explores the potential of antimicrobial peptides (AMPs) and nanotechnology for the treatment of gastrointestinal infections. It analyzes bacterial resistance mechanisms, the antimicrobial actions of AMPs, and advances in nanocarriers, such as lipid‐based, polymeric, metallic, and mesoporous silica systems, that enhance peptide protection ...
Christian Shleider Carnero Canales, Cesar Augusto Roque‐Borda, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Uner Josseph Pinto Apaza, Vanderson de Jesus Silva, Laura Maria Duran Gleriani Primo, Maura Jennifer Martínez‐Morales, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +10 more
wiley   +1 more source

Mucosal Barrier and Th2 Immune Responses Are Enhanced by Dietary Inulin in Pigs Infected With Trichuris suis

Frontiers in Immunology, 2018
Diet composition may play a crucial role in shaping host immune responses and commensal gut microbiota populations. Bioactive dietary components, such as inulin, have been extensively studied for their bioactive properties, particularly in modulating gut
Laura J. Myhill, Sophie Stolzenbach, Tina V. A. Hansen, Kerstin Skovgaard, C. Rune Stensvold, Lee O'Brien Andersen, Peter Nejsum, Helena Mejer, Stig M. Thamsborg, Andrew R. Williams   +9 more
doaj   +1 more source