Results 71 to 80 of about 24,986 (221)

Differential Changes in Expression of Intestinal Antimicrobial Peptide Genes During Ascaris lumbricoides Infection in Zambian Adults Do Not Respond to Helminth Eradication [PDF]

The Journal of Infectious Diseases, 2011
Intestinal helminthiasis modulates immune responses to vaccines and environmental allergens. To explore the impact on intestinal host defense, we assessed expression of antimicrobial peptide genes, together with T cell subset markers and cytokines, in patients with ascariasis before and after treatment.Case patients (n = 27) and control subjects (n ...
Kapulu, MC, Simuyandi, M, Sianongo, S, Mutale, M, Katubulushi, M, Kelly, P   +5 more
openaire   +4 more sources

ParaHox Genes Revisited: From Gut Patterning to Integrated Axial and Neural Organization in Rotifera

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In rotifers, ParaHox genes show a dispersed genomic organization, with Xlox absent across gnathiferans. Exclusive neuronal expression of Gsx and Cdx reveals that ancestral ParaHox genes coordinated neural and epithelial development beyond gut patterning, suggesting an integrated role in early bilaterian body plan organization.
Andreas C. Fröbius, David B. Mark Welch, Holger Herlyn   +2 more
wiley   +1 more source

Mucosal Barrier and Th2 Immune Responses Are Enhanced by Dietary Inulin in Pigs Infected With Trichuris suis

Frontiers in Immunology, 2018
Diet composition may play a crucial role in shaping host immune responses and commensal gut microbiota populations. Bioactive dietary components, such as inulin, have been extensively studied for their bioactive properties, particularly in modulating gut
Laura J. Myhill, Sophie Stolzenbach, Tina V. A. Hansen, Kerstin Skovgaard, C. Rune Stensvold, Lee O'Brien Andersen, Peter Nejsum, Helena Mejer, Stig M. Thamsborg, Andrew R. Williams   +9 more
doaj   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Sustainable control of cyathostomin infections in practice

Equine Veterinary Education, EarlyView.
Summary Cyathostomins are the most prevalent helminths in horses and are found in nearly all grazing groups. These parasites have been shown to exhibit widespread anthelmintic resistance and can cause clinical disease, so they are a growing concern.
J. B. Matthews, T. S. Mair
wiley   +1 more source

Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Schistosomes cause more mortality and morbidity than any other human helminth, but control primarily relies on a single drug that kills adult worms.
Geoffrey N Gobert, Mai H Tran, Luke Moertel, Jason Mulvenna, Malcolm K Jones, Donald P McManus, Alex Loukas   +6 more
doaj   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Revealing the associated microflora hosted by the globally significant parasite Trichostrongylus colubriformis

Scientific Reports
Trichostrongylus colubriformis is a parasitic helminth that primarily infects small ruminants, causing substantial economic losses in the livestock industry. Exploring the microbiome of this helminth might provide insights into the potential influence of
Erwin A. Paz, Eng Guan Chua, Dieter G. Palmer, Johan C. Greeff, Shimin Liu, Carolina Cheuquemán, Shamshad Ul Hassan, Graeme B. Martin, Chin Yen Tay   +8 more
doaj   +1 more source

Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion. [PDF]

PLoS Neglected Tropical Diseases, 2018
A number of features at the host-parasite interface are reminiscent of those that are also observed at the host-tumor interface. Both cancer cells and parasites establish a tissue microenvironment that allows for immune evasion and may reflect functional
Prakash Babu Narasimhan, Leor Akabas, Sameha Tariq, Naureen Huda, Sasisekhar Bennuru, Helen Sabzevari, Robert Hofmeister, Thomas B Nutman, Roshanak Tolouei Semnani   +8 more
doaj   +1 more source

Grassland management and helminth control on cattle farms [PDF]

, 2017
Farmers manage their pastures and grazing animals primarily to ensure that swards provide adequate, quality nutrients to support animal performance, but it is also possible to provide useful levels of parasite control without compromising production.
Forbes, Andrew
core   +1 more source