Results 71 to 80 of about 23,322 (214)

Enrichment of type I interferon signaling in colonic group 2 innate lymphoid cells in experimental colitis

Frontiers in Immunology, 2022
Group 2 innate lymphoid cells (ILC2s) serve as frontline defenses against parasites. However, excluding helminth infections, it is poorly understood how ILC2s function in intestinal inflammation, including inflammatory bowel disease.
Emi Irie, Rino Ishihara, Ichiro Mizushima, Shunya Hatai, Yuya Hagihara, Yoshiaki Takada, Junya Tsunoda, Kentaro Iwata, Yuta Matsubara, Yusuke Yoshimatsu, Hiroki Kiyohara, Nobuhito Taniki, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Toshiaki Teratani, Nobuhiro Nakamoto, Yohei Mikami, Takanori Kanai, Takanori Kanai   +20 more
doaj   +1 more source

Macrophages in wound healing: activation and plasticity. [PDF]

, 2019
Macrophages are critically involved in wound healing, from dampening inflammation to clearing cell debris and coordinating tissue repair. Within the wound, the complexity of macrophage function is increasingly recognized, with adverse outcomes when ...
Kim, Sang Yong, Nair, Meera G
core  

Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1

Allergy, EarlyView.
Sequential switching through IgG1 is not required to produce IgE with sufficient allergen‐binding affinity to cause anaphylaxis against food allergens. Sequential switching through IgG1 does not confer a competitive advantage to become an IgE‐expressing cell.
Joshua F. E. Koenig, Adam K. Wade‐Vallance, Rodrigo Jiménez‐Saiz, Kelly Bruton, Siyon Gadkar, Emily Grydziuszko, Tina D. Walker, Melissa E. Gordon, Amy E. Gillgrass, Justin J. Taylor, Susan Waserman, Manel Jordana   +11 more
wiley   +1 more source

Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.

PLoS Pathogens, 2012
Idiopathic chronic diarrhea (ICD) is a leading cause of morbidity amongst rhesus monkeys kept in captivity. Here, we show that exposure of affected animals to the whipworm Trichuris trichiura led to clinical improvement in fecal consistency, accompanied ...
Mara Jana Broadhurst, Amir Ardeshir, Bittoo Kanwar, Julie Mirpuri, Uma Mahesh Gundra, Jacqueline M Leung, Kirsten E Wiens, Ivan Vujkovic-Cvijin, Charlie C Kim, Felix Yarovinsky, Nicholas W Lerche, Joseph M McCune, P'ng Loke   +12 more
doaj   +1 more source

GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection.

PLoS Pathogens, 2020
Multiple sclerosis (MS) is a highly disabling neurodegenerative autoimmune condition in which an unbalanced immune response plays a critical role. Although the mechanisms remain poorly defined, helminth infections are known to modulate the severity and ...
Juan M Ortiz Wilczyñski, Cinthia M Olexen, Andrea E Errasti, Mirta Schattner, Carla V Rothlin, Jorge Correale, Eugenio A Carrera Silva   +6 more
doaj   +1 more source

Differences in the gene expression profiles of haemocytes from schistosome-susceptible and -resistant biomphalaria glabrata exposed to Schistosoma mansoni excretory-secretory products. [PDF]

PLoS ONE, 2014
During its life cycle, the helminth parasite Schistosoma mansoni uses the freshwater snail Biomphalaria glabrata as an intermediate host to reproduce asexually generating cercariae for infection of the human definitive host.
Zahida Zahoor, Anne E Lockyer, Angela J Davies, Ruth S Kirk, Aidan M Emery, David Rollinson, Catherine S Jones, Leslie R Noble, Anthony J Walker   +8 more
doaj   +1 more source

Comparative transcriptomics of stickleback immune gene responses upon infection by two helminth parasites, Diplostomum pseudospathaceum and Schistocephalus solidus

Zoology, 2016
Immune systems of vertebrates are much more diverse than previously thought, in particular at the base of the vertebrate clade. RNA-seq was used to describe in detail the transcriptomic response of stickleback hosts to infection by two helminth parasites, the trematode Diplostomum pseudospathaceum (2 genotypes plus a genotype mix) and the cestode ...
Haase, David, Rieger, Jennifer K., Witten, Anika, Stoll, Monika, Bornberg-Bauer, Erich, Kalbe, Martin, Schmidt-Drewello, Alexander, Scharsack, Jörn P., Reusch, Thorsten B.H.   +8 more
openaire   +5 more sources

Natural variation in immune responses to neonatal mycobacterium bovis bacillus calmette-guerin (BCG) vaccination in a cohort of Gambian infants [PDF]

, 2008
Background There is a need for new vaccines for tuberculosis (TB) that protect against adult pulmonary disease in regions where BCG is not effective.
A Lalvani, A Marchant, AM Cooper, AP Soares, Arnaud Marchant, AS Pym, AV Hill, B Wu, Ben Marais, Chris Finan, D Elias, D O'Donovan, E Jouanguy, G Dai, G Sirugo, GA Colditz, GA Poland, GF Black, GF Black, H Fletcher, H Mahomed, I Malhotra, J Vekemans, JJ Ellner, LB Reichman, LC Rodrigues, M Bonecini-Almeida, M Ota, MA Behr, MA Horwitz, Martin O. C. Ota, Melanie J. Newport, MJ Newport, MJ Newport, MOC Ota, NE Beveridge, PC Hill, PEM Fine, RE Weir, RE Weir, RH Brookes, S Dupuis, S Mallal, SE Dorman, ST Bennett, TB Stop, V Davids   +46 more
core   +3 more sources

IL‐25 Enhances B Cell Responses in Type 2 Inflammation Through IL‐17RB Receptor

Allergy, Volume 80, Issue 4, Page 965-975, April 2025.
Human B cells express IL‐17RB under IgE inducing conditions (anti‐CD40 + IL‐4) and respond to IL‐25 with enhanced antibody production, particularly IgE. ScRNA‐seq revealed that IL‐17RB+ B cells have a distinct transcriptional profile compared to IL‐17RB‐B cells.
Semah Abdu, Jiao Xia, Huihui Yuan, Tiak Ju Tan, Janice A. Layhadi, Mohamed H. Shamji, Andrew N. J. McKenzie, Nora Haloob, Claire Hopkins, Grzegorz Woszczek, Stephen J. Till   +10 more
wiley   +1 more source

Dietary seaweed (Saccharina latissima) supplementation in pigs induces localized immunomodulatory effects and minor gut microbiota changes during intestinal helminth infection

Scientific Reports, 2023
Brown seaweeds have a rich bioactive content known to modulate biological processes, including the mucosal immune response and microbiota function, and may therefore have the potential to control enteric pathogens.
Charlotte Smith Bonde, Helena Mejer, Laura J. Myhill, Ling Zhu, Penille Jensen, Nilay Büdeyri Gökgöz, Lukasz Krych, Dennis Sandris Nielsen, Kerstin Skovgaard, Stig Milan Thamsborg, Andrew R. Williams   +10 more
doaj   +1 more source