Results 51 to 60 of about 12,335 (183)

Genes associated with alternatively activated macrophages discretely regulate helminth infection and pathogenesis in experimental mouse models

Immunobiology, 2010
Resolution of helminth infections is typically associated with the host launching a TH2 dominated immune response. In experimental models of helminth infections a key feature of this TH2 immunity is the induction of alternatively activated macrophage (AAM) populations.
William G C, Horsnell, Frank, Brombacher
openaire   +2 more sources

Comparative transcriptomics of stickleback immune gene responses upon infection by two helminth parasites, Diplostomum pseudospathaceum and Schistocephalus solidus

Zoology, 2016
Immune systems of vertebrates are much more diverse than previously thought, in particular at the base of the vertebrate clade. RNA-seq was used to describe in detail the transcriptomic response of stickleback hosts to infection by two helminth parasites, the trematode Diplostomum pseudospathaceum (2 genotypes plus a genotype mix) and the cestode ...
Haase, D., Rieger, J., Witten, A., Stoll, M., Bornberg-Bauer, E., Kalbe, M., Schmidt-Drewello, A., Scharsack, J., Reusch, T.   +8 more
openaire   +5 more sources

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

Revealing the associated microflora hosted by the globally significant parasite Trichostrongylus colubriformis

Scientific Reports
Trichostrongylus colubriformis is a parasitic helminth that primarily infects small ruminants, causing substantial economic losses in the livestock industry. Exploring the microbiome of this helminth might provide insights into the potential influence of
Erwin A. Paz, Eng Guan Chua, Dieter G. Palmer, Johan C. Greeff, Shimin Liu, Carolina Cheuquemán, Shamshad Ul Hassan, Graeme B. Martin, Chin Yen Tay   +8 more
doaj   +1 more source

Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Schistosomes cause more mortality and morbidity than any other human helminth, but control primarily relies on a single drug that kills adult worms.
Geoffrey N Gobert, Mai H Tran, Luke Moertel, Jason Mulvenna, Malcolm K Jones, Donald P McManus, Alex Loukas   +6 more
doaj   +1 more source

Health Research Funders and Justice: Obligations to Coordinate and Counterbalance

Bioethics, EarlyView.
ABSTRACT Government health research funders are frequently criticized on the grounds that their distribution of resources fails to reflect a population's disease burden. These critiques do not take into account what other research funders are doing. In this paper, I argue that this is a mistake.
Joseph Millum
wiley   +1 more source

Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection.

PLoS Pathogens, 2023
Gastrointestinal helminths are a major health threat worldwide. Alternatively activated macrophages (AAMs) have been shown to contribute to host protection during secondary helminth infections. AAMs express effector molecules that depend on activation of
Stefanie Westermann, Christoph Schubart, Axel Dietschmann, Kirstin Castiglione, Daniel Radtke, David Voehringer   +5 more
doaj   +1 more source

Sustainable control of cyathostomin infections in practice

Equine Veterinary Education, EarlyView.
Summary Cyathostomins are the most prevalent helminths in horses and are found in nearly all grazing groups. These parasites have been shown to exhibit widespread anthelmintic resistance and can cause clinical disease, so they are a growing concern.
J. B. Matthews, T. S. Mair
wiley   +1 more source

Differential Changes in Expression of Intestinal Antimicrobial Peptide Genes During Ascaris lumbricoides Infection in Zambian Adults Do Not Respond to Helminth Eradication [PDF]

The Journal of Infectious Diseases, 2011
Intestinal helminthiasis modulates immune responses to vaccines and environmental allergens. To explore the impact on intestinal host defense, we assessed expression of antimicrobial peptide genes, together with T cell subset markers and cytokines, in patients with ascariasis before and after treatment.Case patients (n = 27) and control subjects (n ...
Kapulu, MC, Simuyandi, M, Sianongo, S, Mutale, M, Katubulushi, M, Kelly, P   +5 more
openaire   +4 more sources

Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.

PLoS Pathogens, 2012
Idiopathic chronic diarrhea (ICD) is a leading cause of morbidity amongst rhesus monkeys kept in captivity. Here, we show that exposure of affected animals to the whipworm Trichuris trichiura led to clinical improvement in fecal consistency, accompanied ...
Mara Jana Broadhurst, Amir Ardeshir, Bittoo Kanwar, Julie Mirpuri, Uma Mahesh Gundra, Jacqueline M Leung, Kirsten E Wiens, Ivan Vujkovic-Cvijin, Charlie C Kim, Felix Yarovinsky, Nicholas W Lerche, Joseph M McCune, P'ng Loke   +12 more
doaj   +1 more source