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The immunoglobulins and immunoglobulin genes of swine
Veterinary Immunology and Immunopathology, 1994The historical works describing the characterization of swine immunoglobulins are reviewed. The three major isotypes, IgM, IgA and IgG, have been recognized for 25 years and their concentrations in various body fluids, the location of the plasma cells throughout the body which synthesize them and their transport into lacteal secretions and absorption ...
J E, Butler, W R, Brown
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The expression of immunoglobulin genes
Immunology Today, 1988Abstract Transcription of antibody genes is restricted to lymphoid cells and is a process controlled by multiple DNA elements. However, modulation of expression during B-cell ontogeny is effected by post-transcriptional and post-translational processes.
M S, Neuberger, G P, Cook
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Immunoglobulin genes in Primates
Molecular Immunology, 2018Five classes of immunoglobulins are known to exist in mammals. The number of isotypes of classes G, E and A varies among species for unknown reasons. Here, a study of the presence of immunoglobulin genes in Primates was carried out from the genomes and transcriptomes deposited in the NCBI repository.
David N. Olivieri +1 more
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Immunoglobulin Genes in Autoimmunity
International Archives of Allergy and Immunology, 2009The contribution of V germline genes and somatic mutation as well as the mechanism governing expression of the various V family genes in response to self-antigens are still unknown. Thus, we are still far from understanding the contribution and role of the B cell repertoire in human autoimmunity. Much of our current data on autoantibody gene repertoire
P S, Leung, M E, Gershwin
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Immunoglobulin Gene Transcription
Annual Review of Immunology, 1991Transcriptional regulation of the immunoglobulin (Ig) genes is one of the best-studied systems for understanding tissue-restricted gene control. Dissection of the Ig genes reveals that each contains multiple regulatory elements that are preferentially active in B lymphocytes. These include a promoter and one or more enhancer elements.
L M, Staudt, M J, Lenardo
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Immunoglobulin genes of the turtles
Immunogenetics, 2012The availability of reptile genomes for the use of the scientific community is an exceptional opportunity to study the evolution of immunoglobulin genes. The genome of Chrysemys picta bellii and Pelodiscus sinensis is the first one that has been reported for turtles.
Susana, Magadán-Mompó +2 more
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Immunoglobulins and immunoglobulin genes of the horse
Developmental & Comparative Immunology, 2006Antibodies of the horse were studied intensively by many notable immunologists throughout the past century until the early 1970's. After a large gap of interest in horse immunology, additional basic studies on horse immunoglobulin genes performed during the past 10 years have resulted in new insights into the equine humoral immune system. These include
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The immunoglobulin genes of fish
Developmental & Comparative Immunology, 1995Abstract The current state of knowledge concerning the structure, organization, and functional expression of immunoglobulin genes in chondrichthyan and osteichthyan fish is presented.
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Immunoglobulin Gene Diversification
Annual Review of Genetics, 2005Three processes alter genomic sequence and structure at the immunoglobulin genes of B lymphocytes: gene conversion, somatic hypermutation, and class switch recombination. Though the molecular signatures of these processes differ, they occur by a shared pathway which is induced by targeted DNA deamination by a B cell–specific factor, activation induced
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Immunoglobulin mRNA and Immunoglobulin Genes
1976The genetic origin of antibody diversity has been a subject of much thought and controversy over the past 20 years. Extensive studies of immunoglobulins, particularly at the amino acid sequence level, have provided us with a general scheme of the genetic loci which encode antibody molecules (Fig. 1).
C. Milstein +5 more
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