Results 101 to 110 of about 520,866 (339)
Expression Changes of MHC and Other Immune Genes in Frog Skin during Ontogeny
Animals, 2020 Anuran amphibians undergo major physiological and immunological changes following metamorphosis. Genes of the major histocompatibility complex (MHC) code for receptors important for vertebrate adaptive immunity.
Quintin Lau +3 more
doaj +1 more source
BMC Molecular and Cell Biology, 2021 Background The crucial role of the major histocompatibility complex (MHC) for the immune response to infectious diseases is well-known, but no information is available on the 3D nuclear organization of this gene-dense region in immune cells, whereas ...
Florence Mompart +7 more
doaj +1 more source
Trans-allelic model for prediction of peptide:MHC-II interactions [PDF]
arXiv, 2017 Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, helper T cells mount an immune response against invading pathogens.
arxiv
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
BMC Genomics, 2017 Background Bats are an extremely successful group of mammals and possess a variety of unique characteristics, including their ability to co-exist with a diverse range of pathogens.
Justin H. J. Ng +3 more
doaj +1 more source
Epitope prediction improved by multitask support vector machines [PDF]
We use various multitask kernels in order to improve MHC-I-peptide
binding prediction, in particular for MHC alleles for which few training data
is available. (05/02/2007), 2007 Motivation: In silico methods for the prediction of antigenic peptides binding to MHC class I molecules play an increasingly important role in the identification of T-cell epitopes. Statistical and machine learning methods, in particular, are widely used to score candidate epitopes based on their similarity with known epitopes and non epitopes.
arxiv
UDP‐glucose dehydrogenase variants cause dystroglycanopathy
Annals of Clinical and Translational Neurology, EarlyView.Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs +8 more
wiley +1 more source
HLA class I binding prediction via convolutional neural networks [PDF]
arXiv, 2017 Many biological processes are governed by protein-ligand interactions. One such example is the recognition of self and nonself cells by the immune system. This immune response process is regulated by the major histocompatibility complex (MHC) protein which is encoded by the human leukocyte antigen (HLA) complex.
arxiv
, 2005 Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants.
Drozina, G. +3 more
core +2 more sources
The MHC and the Recognition of Self and Altered Self in Experimental and Rheumatoid Arthritis [PDF]
, 2014 The Major histocompatibility complex (MHC) is a highly polymorphic and genedense region on chromosome 6 in humans and 20 in the rat. Genes in the MHC are the major risk factor for the development of autoimmunity.
Haag, Sabrina
core +1 more source