Results 121 to 130 of about 520,866 (339)
An Improved Version of the Symmetrical Immune Network Theory [PDF]
arXiv, 2010 An improved version of the symmetrical immune network theory is presented, in which killing is ascribed to IgM antibodies, while IgG antibodies are stimulatory. A recurring theme in the symmetrical network theory is the concept of co-selection. Co-selection is the mutual positive selection of individual members from within two diverse populations, such
arxiv
Major histocompatibility complex class I involvement in the rejection of allogeneic erythrocytes in rainbow trout (Oncorhynchus mykiss) [PDF]
, 2003 Major histocompatibility complex genes are thought to be involved in allogeneic graft rejection but not many reports are available on their functional analysis in fish.
Sarder, M.R.I.
core
Advanced Healthcare Materials, EarlyView.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source
Influences of MHC Class II Haplotypes on Avian Influenza Traits in Thai Indigenous Chicken
The Journal of Poultry Science, 2006 Natural infections with influenza viruses have been reported in a variety of animal species including human, pigs, horses, sea mammals, mustelids and birds.
Kalaya Boonyanuwat +5 more
doaj +1 more source
Humoral immunocompetence in relation to condition, size, asymmetry and MHC class II variation in great snipe (Gallinago media) males [PDF]
arXiv, 2013 1. In recent years many studies have investigated the relationships between different aspects of the immune system and ecology in various organisms. Yet, it remains unclear why individuals differ in their ability to mount an immune response against various antigens (often referred to as 'immunocompetence'). Different kinds of trade-offs may be involved
arxiv
Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction
Advanced Healthcare Materials, EarlyView.This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi +13 more
wiley +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
Advanced Materials, Volume 37, Issue 12, March 26, 2025.Tissue‐repairing macrophages compromise radiotherapy‐induced antitumor immunity. An alkaline adjuvant (MgAl‐based hydrotalcite, bLDH) reverses the situation. After engendering macrophages to phagocytose irradiated cancer cells, bLDH is administrated and improves the cross‐presentation of engulfed tumor antigens over tenfold. bLDH limits the activity of
Bei Li +9 more
wiley +1 more source
Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma
Advanced Materials, Volume 37, Issue 16, April 23, 2025.A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura +19 more
wiley +1 more source
Advanced Science, EarlyView.Iron deficiency reduces monocyte dendritic cell progenitor (MDP) numbers by inhibiting migration and proliferation while promoting apoptosis, subsequently reducing downstream common dendritic cell precursors (CDP) and dendritic cell (DC). Impaired DCs enter the lungs via blood circulation, where reduced antigen presentation impairs T‐cell activation ...
Quanzhong Ren +8 more
wiley +1 more source