Results 131 to 140 of about 520,866 (339)

BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies [PDF]

arXiv, 2010
Gene-gene interactions have long been recognized to be fundamentally important to understand genetic causes of complex disease traits. At present, identifying gene-gene interactions from genome-wide case-control studies is computationally and methodologically challenging.
arxiv  

Transcriptional and post-transcriptional regulation of human MHC class II genes require the synthesis of short-lived proteins.

Journal of Immunology, 1989
We have studied the stability of protein factors which control the intracellular levels of human MHC class II genes in B cells. We report that human MHC class II gene transcription and mRNA stability require the synthesis of short-lived proteins which ...
A. Maffei, C. Perfetto, N. Ombra, G. Del Pozzo, J. Guardiola   +4 more
semanticscholar   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Association between NDO-LID and PGL-1 for leprosy and class I and II human leukocyte antigen alleles in an indigenous community in Southwest Amazon

Brazilian Journal of Infectious Diseases, 2020
The frequencies of the Human leukocyte antigen (HLA) alleles in the Puyanawa indigenous reserve population and their association with the NDO-LID and ELISA PGL-1 rapid serological test was assessed.
Stéfanie Ferreira Teles, Eliane Aparecida Silva, Rodrigo Medeiros de Souza, Jane Tomimori, Marcos Cesar Florian, Rogério Oliveira Souza, Elaine Valim Camarinha Marcos, Fabiana Covolo de Souza-Santana, Mônica Antar Gamba   +8 more
doaj  

The Shrinkage Variance Hotelling $T^2$ Test for Genomic Profiling Studies [PDF]

arXiv, 2017
Designed gene expression micro-array experiments, consisting of several treatment levels with a number of replicates per level, are analyzed by applying simple tests for group differences at the per gene level. The gene level statistics are sorted and a criterion for selecting important genes which takes into account multiplicity is applied.
arxiv  

Tolerance to solid organ transplants through transfer of MHC class II genes.

Journal of Clinical Investigation, 2001
Donor/recipient MHC class II matching permits survival of experimental allografts without permanent immunosuppression, but is not clinically applicable due to the extensive polymorphism of this locus.
Kai-C. Sonntag, David W. Emery, Akihiko Yasumoto, Gary Haller, S. Germana, Tomasz Sablinski, Akira Shimizu, K. Yamada, H. Shimada, S. Arn, David H. Sachs, C. Leguern   +11 more
semanticscholar   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Cell Reports, 2023
Summary: Disruption of antigen presentation via loss of major histocompatibility complex (MHC) expression is a strategy whereby cancer cells escape immune surveillance and develop resistance to immunotherapy.
Michael B. Mumphrey, Noshad Hosseini, Abhijit Parolia, Jie Geng, Weiping Zou, Malini Raghavan, Arul Chinnaiyan, Marcin Cieslik   +7 more
doaj  

The Utility of Supertype Clustering in Prediction for Class II MHC-Peptide Binding

Molecules, 2018
Motivation: Extensive efforts have been devoted to understanding the antigenic peptides binding to MHC class I and II molecules since they play a fundamental role in controlling immune responses and due their involvement in vaccination, transplantation ...
Wen-Jun Shen, Xun Zhang, Shaohong Zhang, Cheng Liu, Wenjuan Cui   +4 more
doaj   +1 more source

Sepsis is a syndrome with hyperactivity of TH17-like innate immunity and hypoactivity of adaptive immunity [PDF]

arXiv, 2013
Currently, there are two major theories for the pathogenesis of sepsis: hyperimmune and hypoimmune. Hyperimmune theory suggests that cytokine storm causes the symptoms of sepsis. On the contrary, hypoimmune theory suggests that immunosuppression causes the manifestations of sepsis.
arxiv