Results 301 to 310 of about 520,866 (339)
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A model for the transcriptional regulation of MHC class II genes
Immunology Today, 1987The analysis of la antigens has focused primarily on their structure and function. However, the quantitative differences in immune response gene expression are equally important, since variation of cell surface la influences immunoregulation and the expression of immunologically mediated disease.
Kate E. Sullivan +5 more
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Role of MHC Class II Genes in the pathogenesis of pemphigoid
Autoimmunity Reviews, 2011Pemphigoid (Pg) is an autoimmune subepidermal blistering disease that affects the elderly population. The phenotype can be Bullous Pemphigoid (BP), which primarily involves the skin, or Mucous Membrane Pemphigoid (MMP), which primarily involves mucus membranes. Ocular Cicatricial Pemphigoid (OCP) and Oral Pemphigoid (OP) are subsets of MMP.
Pedro A. Reche +2 more
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How are class II MHC genes turned on and off?
The FASEB Journal, 1995Fragments of foreign antigen are detected by CD4+ helper T cells via the T cell receptor for antigen in the context of major histocompatibility complex (MHC) class II molecules. Very few cells normally express class II MHC molecules, and these cells play critical roles in antigen presentation and in the thymic selection of T lymphocytes before their ...
Santa Jeremy Ono, Sarki A. Abdulkadir
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1990
MHC (Major Histocompatibility Complex) Class II antigens are polymorphic cell surface glycoproteins which bind foreign antigens and form a complex which is recognized by T lymphocyte antigen receptors. Presentation of foreign antigens by self MHC molecules to T cells triggers antigen-specific responses in the immune system.
Laurie H. Glimcher +3 more
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MHC (Major Histocompatibility Complex) Class II antigens are polymorphic cell surface glycoproteins which bind foreign antigens and form a complex which is recognized by T lymphocyte antigen receptors. Presentation of foreign antigens by self MHC molecules to T cells triggers antigen-specific responses in the immune system.
Laurie H. Glimcher +3 more
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MHC class II A genes in the channel catfish (Ictalurus punctatus)
Developmental & Comparative Immunology, 1997Two different cDNA sequences for major histocompatibility complex (MHC) class II beta chains from the channel catfish (Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus.
Ulla B. Godwin +6 more
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The Journal of Immunology, 1996
Abstract Homologues of the human HLA-A and -B MHC class I loci have been found in great apes and Old World primates suggesting that these two loci have existed for at least 30 million years. The C locus, however, shows some sequence similarity to the B locus and has been found only in gorillas, chimpanzees, and humans.
Jonathan E. Boyson +6 more
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Abstract Homologues of the human HLA-A and -B MHC class I loci have been found in great apes and Old World primates suggesting that these two loci have existed for at least 30 million years. The C locus, however, shows some sequence similarity to the B locus and has been found only in gorillas, chimpanzees, and humans.
Jonathan E. Boyson +6 more
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Structure and function of genes in the MHC class II region
Current Opinion in Immunology, 1993Genes required for antigen processing map to the MHC class II region. For the endogenous (class I) antigen processing pathway, many hypotheses concerning the structure and function of the corresponding gene products have been verified during the past year. The identity of the gene(s) involved in the exogenous (class II) pathway remains to be determined.
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The Generation and Maintenance of MHC Class II Gene Polymorphism in Rodents
Immunological Reviews, 1990Etude de la diversification du gene Aβ du site de fixation de l'antigene dans la molecule de classe II du systeme d'histocompatibilite majeur des ...
Edward K. Wakeland +2 more
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Combined immunodeficiency with abnormal expression of MHC class II genes
Clinical Immunology and Immunopathology, 1989The MHC class II CID represents an example of immunodeficiency in which the defect in expression of membrane glycoproteins leads to abnormal cell to cell interactions and thus to abnormal immune responses. It represents an interesting model which confirms the importance of MHC molecules in all immune responses to foreign antigens.
Anne-Marie Fischer +7 more
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CIITA activates the expression of MHC class II genes in mouse T cells.
International Immunology, 1995It has long been a puzzle that MHC class II molecules are expressed in human T cells after activation but not in mouse T cells; this expression is believed to play a role in the cell mediated immune response.
Cheong-Hee Chang +4 more
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