Results 171 to 180 of about 239,792 (215)

Myc target genes

Trends in Biochemical Sciences, 1997
The myc family of proto-oncogenes belongs to the basic helix-loop-helix leucine-zipper (bHLHZ) class of transcription factors. Myc proteins function as transcriptional activators through heterodimerization with Max, but might also act as negative regulators of transcription.
C, Grandori, R N, Eisenman
openaire   +2 more sources

The c-Myc target gene network

Seminars in Cancer Biology, 2006
For more than a decade, numerous studies have suggested that the c-Myc oncogenic protein is likely to broadly influence the composition of the transcriptome. However, the evidence required to support this notion was made available only recently, much to the anticipation of an eagerly awaiting field.
Chi V Dang, Kathryn A O'Donnell, Karen I Zeller   +2 more
exaly   +3 more sources

Target gene-independent functions of MYC oncoproteins

Nature Reviews Molecular Cell Biology, 2020
Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large body of evidence indicates that MYC proteins are transcription factors, studying their function has focused on the biology of their target genes. Detailed studies of MYC-dependent changes in RNA levels have provided contrasting models of the oncogenic activity of MYC
Apoorva Baluapuri, Elmar Wolf, Martin Eilers   +2 more
exaly   +4 more sources

Expression Profiles of MYC Protein and MYC Gene Rearrangement in Lymphomas

American Journal of Surgical Pathology, 2015
MYC translocations are a defining feature of Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL) with inferior outcome. However, the clinical relevance of MYC gene rearrangement and its relationship with MYC protein expression has not been well characterized in lymphomas.
Karen M, Chisholm, Charles D, Bangs, Carlos E, Bacchi, Hernan, Molina-Kirsch, Athena, Cherry, Yasodha, Natkunam   +5 more
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Regulation of gene transcription by the oncoprotein MYC

Gene, 2012
The proteins of the MYC/MAX/MAD network are central regulators of many key processes associated with basic cell physiology. These include the regulation of protein biosynthesis, energy metabolism, proliferation, and apoptosis. Molecularly the MYC/MAX/MAD network achieves these broad activities by controlling the expression of many target genes, which ...
Bernhard, Lüscher, Jörg, Vervoorts
openaire   +2 more sources

MYC protein interactors in gene transcription and cancer

Nature Reviews Cancer, 2021
The transcription factor and oncoprotein MYC is a potent driver of many human cancers and can regulate numerous biological activities that contribute to tumorigenesis. How a single transcription factor can regulate such a diverse set of biological programmes is central to the understanding of MYC function in cancer.
Corey Lourenco, Diana Resetca, Cornelia Redel, Peter Lin, Alannah S. MacDonald, Roberto Ciaccio, Tristan M. G. Kenney, Yong Wei, David W. Andrews, Maria Sunnerhagen, Cheryl H. Arrowsmith, Brian Raught, Linda Z. Penn   +12 more
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Deregulation of the c-myc and N-myc Genes in Transformed Cells

1988
Expression of the c-myc proto-oncogene is regulated by mitogens in a number of cell types, including fibroblasts and lymphoid cells. In growth arrested fibroblasts, serum, epidermal growth factor, or platelet derived growth factor are all capable of inducing c-myc mRNA (Campisi et al., 1984; Kelly et al.,1983).
M, Dean, J, Cleveland, H Y, Kim, J, Campisi, R A, Levine, J N, Ihle, U, Rapp   +6 more
openaire   +2 more sources

Myc Target Genes in Neoplastic Tranformation

1997
Deregulated expression of the c-myc oncogene as a consequence of specific genetic alterations is sine-qua-non for certain B-cell neoplasms. Dissection of the c-Myc protein over the last decade reveals a structural organization that is characteristic of a transcription factor.
H, Shim, B C, Lewis, C, Dolde, Q, Li, C S, Wu, Y S, Chun, C V, Dang   +6 more
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Molecular analysis of myc gene mutants

Proceedings of the Royal Society of London. Series B. Biological Sciences, 1985
Abstract We describe the generation and characterization of a series of deletion mutants of the avian acute leukaemia virus MC29 which allow the study of the function of the myc in transformation of quail embryo fibroblasts in vitro and tumour induction in vivo.
P J, Enrietto, M J, Hayman
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Sporadic Amplification of the MYC Gene in Human Osteosarcomas

Diagnostic Molecular Pathology, 1993
The MYC proto-oncogene has been shown to be overexpressed in several types of sarcomas, including some osteosarcomas. In most cases, the overexpression is due to gene amplification. The total number of osteosarcoma patients studied, however, remains too small to derive any conclusions regarding the true prevalence and the possible clinical significance
M, Ladanyi, C K, Park, R, Lewis, S C, Jhanwar, J H, Healey, A G, Huvos   +5 more
openaire   +2 more sources