Results 181 to 190 of about 239,792 (215)

Expression of c-myc gene in human hepatoma

Biochemical and Biophysical Research Communications, 1985
The level of c-myc transcript was examined in liver samples from seven hepatoma patients. Transcripts were detected in all the normal liver parts examined; in contrast, in two hepatoma parts, there was a dramatic reduction in c-myc transcripts. The restriction enzyme pattern of c-myc gene appeared the same among samples.
T S, Su, L H, Lin, W Y, Lui, C M, Chang, C K, Chou, L P, Ting, C P, Hu, S H, Han, F K, P'eng   +8 more
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c-myc Transactivates the Ornithine Decarboxylase Gene

1992
Several observations suggest that the c-myc proto-oncogene is a key regulator of cell growth and differentiation. First, expression of c-myc RNA and protein is tightly regulated by mitogens and are suppressed by growth inhibitory agents (Luscher and Eisenman, 1991).
C, Bello-Fernandez, J L, Cleveland
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Immortalization by truncated myc or ras genes and synergism between myc and ras genes in cell transformation.

Anticancer research, 1989
Human c-myc and normal or mutant T24 H-ras1 genes either linked to the regulatory sequences of the human metallothionein IIa gene or unlinked have been employed individually or in combination to transfect early passage Chinese hamster lung cells.
Spandidos, Demetrios A., Lang, J. C.
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Downstream Regulatory Elements in the c-myc Gene

1990
Deregulated expression of the c-myc gene appears to play an important role in the development of Burkitt’s lymphoma (BL) and certain other lymphoid tumors. Physiologic regulation of the c-myc gene is complicated, involving the interplay of distinct transcriptional and post transcriptional mechanisms.
M, Zajac-Kaye, B, Yu, N, Ben-Baruch
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c-myc gene activation and chromosomal translocation

Journal of Cell Science, 1984
ABSTRACT Burkitt’s lymphoma cells are characterized by the presence of specific chromosomal translocation bringing the immunoglobulin and the c-myc proto-oncogenes into the proximity of each other. Different translocations involve each of the three immunoglobulin loci but the breakpoint with respect to the c-myc gene is shown to be very ...
T H, Rabbitts, R, Baer, M, Davis, A, Forster, P H, Rabbitts, S, Malcolm   +5 more
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Amplification and expression of the N-myc gene in neuroblastoma

European Journal of Pediatrics, 1987
Genomic configuration and expression of the N-myc gene was investigated by Southern and Northern blot analyses in 18 neuroblastomas of different clinical stages. We observed a 4-100-fold amplification of this oncogene in one of six stage III, two of four stage IV as well as one of five stage IVS tumours.
C R, Bartram, F, Berthold
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[A study of amplifications of myc gene (c-myc and N-myc) in human ovarian cancer].

Nihon Sanka Fujinka Gakkai zasshi, 1990
Amplifications of myc oncogenes (c-myc, N-myc) were studied by Southern blot hybridization methods in ovarian cancers. Fourteen cases were primary ovarian cancers and one case was metastatic ovarian cancer. Primary and metastatic foci of three primary ovarian cancers were compared.
A, Kataoka, M, Yakushiji, M, Kojiro
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Abnormal regulation of the myc gene in myeloid leukemia

Medical Oncology and Tumor Pharmacotherapy, 1992
To study the regulation of expression of the myc protooncogene, cells from normal individuals and patients with acute myelogenous leukemia (AML), and chronic phase and blastic crisis of chronic myeloid leukemia (CML) cells were put in overnight culture in the presence or absence of fetal calf serum.
V, Gopal, P, Kadam, H, Preisler, B, Hulette, Y Q, Li, P, Steele, J, Freeman, S, Banavali   +7 more
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Chromosomal location of N-myc and L-myc genes in the mouse.

Oncogene research, 1989
The myc family of proto-oncogenes consists of at least three members, whose expression is tightly and co-ordinately regulated. The genes are nevertheless dispersed to three distinct chromosomal sites in humans. We have now used somatic cell genetics and the analysis of restriction fragment length polymorphisms (RFLPs) to identify and chromosomally map ...
G R, Campbell, K, Zimmerman, R D, Blank, F W, Alt, P, D'Eustachio   +4 more
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The Myc Gene

2021
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