Results 191 to 198 of about 26,095 (198)
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Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene
Science, 1992Vaccine protection against the human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV) in animal models is proving to be a difficult task. The difficulty is due in large part to the persistent, unrelenting nature of HIV and SIV infection once infection is initiated.
M D, Daniel +4 more
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Importance of the nef gene for maintenance of high virus loads and for development of AIDS
Cell, 1991When rhesus monkeys were infected with a form of cloned SIVmac239 having a premature stop signal at the 93rd codon of nef, revertants with a coding codon at this position quickly and universally came to predominate in the infected animals. This suggests that there are strong selective forces for open functional forms of nef in vivo.
H W, Kestler +6 more
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The nef gene products: biochemical properties and effects on host cell functions
Research in Virology, 1992A R, Nebreda, F, Segade, E, Santos
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[Function of human immunodeficiency virus type 1 nef gene product in virus replication].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1996We comparatively analyzed the replication kinetics of wild-type (wt) and nef mutant human immunodeficiency virus type 1 (HIV-1) in several CD4-positive cell lines, in order to clarify the molecular function of Nef protein. The delayed growth of nef mutant virus was observed at the initial stage of replication in all cell lines examined. This phenomenon
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[HIV nef gene and nef protein].
Nihon rinsho. Japanese journal of clinical medicine, 1994K, Obaru, S, Matsushita, K, Takatsuki
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