Neferine inhibits vascular smooth muscle cell proliferation and migration in atherosclerosis by targeting CYS130 and PHE252 in PTEN [PDF]
Frontiers in PharmacologyIntroductionThe abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are significant pathological factors contributing to atherosclerosis (AS).
Qi Jin +21 more
doaj +2 more sources
Nef as a driver of immunodeficiency and HIV-associated diseases: insights from mouse models [PDF]
Frontiers in ImmunologyNef is a non-structural regulatory protein of human immunodeficiency virus (HIV) that exerts pleiotropic effects on the immune system. In infected cells, Nef modulates the surface expression of molecules critical for immune responses and regulates ...
A.S. Yakovleva +11 more
doaj +2 more sources
HIV‐1 Nef is carried on the surface of extracellular vesicles
Journal of Extracellular VesiclesExtracellular vesicles (EVs) serve as pivotal mediators of intercellular communication in both health and disease, delivering biologically active molecules from vesicle‐producing cells to recipient cells.
Michael Bukrinsky
exaly +2 more sources
Diagnóstico incidental de apendicitis aguda por colonoscopia, reporte de un caso
Revista Ciencias Biomédicas, 2021 Introducción: la apendicitis aguda es una de las causas más comunes de abdomen agudo y una de las indicaciones más frecuentes de cirugía abdominal de urgencia.
Iván Aguancha Segebre +5 more
doaj +1 more source
Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomized trial
Critical Care, 2022 Background SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation–perfusion mismatch that can be characterized using subtraction computed tomography angiography ...
Mario G. Santamarina +18 more
doaj +1 more source
Malignancy risk of thyroid nodules with nonshadowing echogenic foci [PDF]
Ultrasonography, 2021 Purpose This study was conducted to determine the malignancy risk and diagnostic value of various types of nonshadowing echogenic foci (NEF) in the risk stratification of thyroid nodules.
Yu-Mee Sohn +4 more
doaj +1 more source
Identificação de pacientes com hipertensão resistente e pseudorresistente em uma Unidade de Saúde da Família [PDF]
Infarma: Pharmaceutical Sciences, 2017 A Hipertensão Resistente (HAR) se manifesta quando os valores de pressão arterial (PA) permanecem acima da meta, apesar do uso regular de três classes de fármacos anti-hipertensivos, incluindo um diurético.
Felipe Vieira da SILVA +3 more
doaj +1 more source
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. [PDF]
PLoS ONE, 2011 Increased spread of HIV-1 and rapid emergence of drug resistance warrants development of novel antiviral strategies. Nef, a critical viral pathogenicity factor that interacts with host cell factors but lacks enzymatic activity, is not targeted by current
Sebastian Breuer +5 more
doaj +1 more source
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1
Frontiers in Microbiology, 2020 Nef is an accessory protein encoded by human immunodeficiency virus type-1 (HIV-1) and plays important roles in regulating HIV-1 infection and viral replication.
Hong-Guang Zhang +29 more
doaj +1 more source
Heliyon, 2023 Purpose: To evaluate whether a subtraction CT angiography (sCTA) perfusion score may have prognostic value in patients with COVID-19 pneumonia. Method: This prospective cohort study included adult patients with RT-PCR-confirmed SARS-CoV-2 infection ...
Mario G. Santamarina +9 more
doaj +1 more source