Results 1 to 10 of about 1,307 (146)

HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection

Frontiers in Microbiology, 2019
HIV Nef is a central auxiliary protein in HIV infection and pathogenesis. Our results indicate that HDAC6 promotes the aggresome/autophagic degradation of the viral polyprotein Pr55Gag to inhibit HIV-1 production.
Romina Cabrera-Rodriguez, Judith Estévez-Herrera, Silvia Pérez-Yanes   +2 more
exaly   +3 more sources

Diagnóstico incidental de apendicitis aguda por colonoscopia, reporte de un caso

Revista Ciencias Biomédicas, 2021
Introducción: la apendicitis aguda es una de las causas más comunes de abdomen agudo y una de las indicaciones más frecuentes de cirugía abdominal de urgencia.
Iván Aguancha Segebre, Gonzalo Araneda Muñoz, Alejandro Ceriani Bravo, Gabriel Antonio Arrieta Pérez, Jorge Vega Stieb, Francisco Palma Carvajal   +5 more
doaj   +1 more source

Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomized trial

Critical Care, 2022
Background SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation–perfusion mismatch that can be characterized using subtraction computed tomography angiography ...
Mario G. Santamarina, Ignacio Beddings, Felipe Martinez Lomakin, Dominique Boisier Riscal, Mónica Gutiérrez Claveria, Jaime Vidal Marambio, Nicole Retamal Báez, Cristian Pavez Novoa, César Reyes Allende, Paulina Ferreira Perey, Miguel Gutiérrez Torres, Camila Villalobos Mazza, Constanza Vergara Sagredo, Sebastian Ahumada Bermejo, Eduardo Labarca Mellado, Elizabeth Barthel Munchmeyer, Solange Marchant Ramos, Mariano Volpacchio, Jorge Vega   +18 more
doaj   +1 more source

Malignancy risk of thyroid nodules with nonshadowing echogenic foci [PDF]

Ultrasonography, 2021
Purpose This study was conducted to determine the malignancy risk and diagnostic value of various types of nonshadowing echogenic foci (NEF) in the risk stratification of thyroid nodules.
Yu-Mee Sohn, Dong Gyu Na, Wooyul Paik, Hye Yun Gwon, Byeong-Joo Noh   +4 more
doaj   +1 more source

Identificação de pacientes com hipertensão resistente e pseudorresistente em uma Unidade de Saúde da Família [PDF]

Infarma: Pharmaceutical Sciences, 2017
A Hipertensão Resistente (HAR) se manifesta quando os valores de pressão arterial (PA) permanecem acima da meta, apesar do uso regular de três classes de fármacos anti-hipertensivos, incluindo um diurético.
Felipe Vieira da SILVA, Martha Gabriela Zambrana de AMORIM, Alfredo Dias de OLIVEIRA FILHO, Sabrina Joany Felizardo NEVES   +3 more
doaj   +1 more source

COVID-19 pneumonia: Perfusion abnormalities shown on subtraction CT angiography in apparently well-ventilated lungs. A prospective cohort study

Heliyon, 2023
Purpose: To evaluate whether a subtraction CT angiography (sCTA) perfusion score may have prognostic value in patients with COVID-19 pneumonia. Method: This prospective cohort study included adult patients with RT-PCR-confirmed SARS-CoV-2 infection ...
Mario G. Santamarina, Felipe Martinez Lomakin, Ignacio Beddings, Dominique Boisier Riscal, Jose Chang Villacís, Roberto Contreras, Jaime Vidal Marambio, Eduardo Labarca, Jorge Torres, Mariano Volpacchio   +9 more
doaj   +1 more source

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. [PDF]

PLoS ONE, 2011
Increased spread of HIV-1 and rapid emergence of drug resistance warrants development of novel antiviral strategies. Nef, a critical viral pathogenicity factor that interacts with host cell factors but lacks enzymatic activity, is not targeted by current
Sebastian Breuer, Simone I Schievink, Antje Schulte, Wulf Blankenfeldt, Oliver T Fackler, Matthias Geyer   +5 more
doaj   +1 more source

Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1

Frontiers in Microbiology, 2020
Nef is an accessory protein encoded by human immunodeficiency virus type-1 (HIV-1) and plays important roles in regulating HIV-1 infection and viral replication.
Hong-Guang Zhang, Hong-Guang Zhang, Jing Guo, Jing Guo, Yukang Yuan, Yukang Yuan, Yibo Zuo, Yibo Zuo, Jin Liu, Li Zhu, Ying Miao, Ying Miao, Xiangjie Chen, Xiangjie Chen, Lincong Jin, Lincong Jin, Fan Huang, Fan Huang, Tengfei Ren, Tengfei Ren, Jiuyi He, Jiuyi He, Weifeng Shi, Zhenke Wen, Chuanwu Zhu, Hui Zheng, Hui Zheng, Chunsheng Dong, Chunsheng Dong, Feng Qian   +29 more
doaj   +1 more source

Folie et société(s) au tournant du Moyen Âge et de la Renaissance

Babel: Littératures Plurielles, 2012
Dans le chapitre d’ouverture de son Histoire de la folie, Foucault convoque pêle-mêle différents objets pour faire naître deux idées fortes : l’emblème que constitue la Nef des fous d’une part, et d’autre part le grand partage entre expériences cosmique ...
Christine Bénévent
doaj   +1 more source

Strictly nef divisors [PDF]

Mathematische Annalen, 2008
Let $X$ be a projective manifold of dimension $n$ and $L$ a strictly nef line bundle on $X$. Then $K_X+tL$ is ample if $t > n+1$ in the following cases. 1.) $\text{dim} X = 3$ unless (possibly) $X$ is a Calabi-Yau with $c_2 \cdot L=0$; 2.) $κ(X) \ge n-2$; 3.) $\text{dim} α(X) \ge n-2$, with $α: X \to A$ the Albanese map.
Campana, F., Chen, J.A., Peternell, T.
openaire   +4 more sources