Results 11 to 20 of about 1,307 (146)
A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef
Cell Reports, 2018 We recently identified the multipass transmembrane protein SERINC5 as an antiviral protein that can potently inhibit HIV-1 infectivity and is counteracted by HIV-1 Nef.
Weiwei Dai +3 more
doaj +1 more source
mBio, 2023 Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of progeny virions ...
Balaji Olety +4 more
doaj +1 more source
A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.
PLoS ONE, 2015 To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef.
Marta Martínez-Bonet +7 more
doaj +1 more source
COVID-19: What Iodine Maps From Perfusion CT can reveal—A Prospective Cohort Study
Critical Care, 2020 Background Subtraction CT angiography (sCTA) is a technique used to evaluate pulmonary perfusion based on iodine distribution maps. The aim of this study is to assess lung perfusion changes with sCTA seen in patients with COVID-19 pneumonia and correlate
Mario G. Santamarina +6 more
doaj +1 more source
Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants. [PDF]
PLoS ONE, 2015 Nef is an accessory viral protein that promotes HIV-1 replication, facilitating alterations in cellular pathways via multiple protein-protein interactions.
Reshu Saxena +5 more
doaj +1 more source
Viruses, 2021 Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC).
Zita Kruize +6 more
doaj +1 more source
Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41. [PDF]
PLoS Pathogens, 2011 Primate lentivirus nef is required for sustained virus replication in vivo and accelerated progression to AIDS. While exploring the mechanism by which Nef increases the infectivity of cell-free virions, we investigated a functional link between Nef and ...
Rachel P J Lai +6 more
doaj +1 more source
Exosomes are unlikely involved in intercellular Nef transfer. [PDF]
PLoS ONE, 2015 HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Several recent studies including ours have demonstrated that Nef can be transferred to neighboring cells and alters the function of these cells.
Xiaoyu Luo +3 more
doaj +1 more source
A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. [PDF]
PLoS ONE, 2018 The HIV-1 Nef accessory protein is essential for viral pathogenicity and AIDS progression. Nef forms complexes with multiple host cell factors to facilitate viral replication and promote immune escape of HIV-infected cells.
Mousheng Wu +4 more
doaj +1 more source
Nefs d’Or, Nefs d’Argent Between Space and Power
, 2022 The so-called nefs were an important ‘presence’ in the European courts starting from the Late Middle Ages. They were precious miniature ships, shown during banquets held in the halls of the nobility. In addition to delighting the sight of diners thanks to their ornamental richness, they were used as containers of spices, drinks, or luxury silverware ...
Andrea Missagia, Feliciano Tosetto
openaire +2 more sources