Results 11 to 20 of about 39,677 (245)

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. [PDF]

PLoS ONE, 2015
To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef.
Marta Martínez-Bonet, Claudia Palladino, Veronica Briz, Jochen M Rudolph, Oliver T Fackler, Miguel Relloso, Maria Angeles Muñoz-Fernandez, Ricardo Madrid   +7 more
doaj   +3 more sources

A Critical History of Co-Production in the Design and Delivery of UK Mental Health Services. [PDF]

Health Expect
ABSTRACT Background The term co‐production is now very common and risks losing its original egalitarian and emancipatory meaning. Questions about what the term means relate to how the concept developed historically. We conduct a critical history of the concept to shed some light on this and inform contemporary practice.
Fleischmann P, Schofield P.
europepmc   +2 more sources

Expression, intracellular targeting and purification of HIV Nef variants in tobacco cells [PDF]

, 2007
Background Plants may represent excellent alternatives to classical heterologous protein expression systems, especially for the production of biopharmaceuticals and vaccine components.
Buriani, Giampaolo, Nuttall, James, Marusic Carla, Lombardi Raffaele, Lombardi, Raffaele, Baschieri , Selene, Buriani Giampaolo, Eugenio Benvenuto, Lico Chiara, Baschieri Selene, Frigerio, Lorenzo, James Nuttall, Benvenuto Eugenio, Lorenzo Frigerio, Nuttall James, Giampaolo Buriani, Marusic, Carla, Selene Baschieri, Frigerio Lorenzo, Raffaele Lombardi, Benvenuto, Eugenio, Chiara Lico, Carla Marusic, Lico, Chiara   +23 more
core   +1 more source

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]

, 2013
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
NADAI, MATTEO, PALU', GIORGIO, Qiu, Jianming, Smithgall, TE, Jerrod A Poe, J. A. Poe, Palumbo, M, Matteo Nadai, Ilaria Frasson, Poe, Jerrod A., Giorgio Palù, RICHTER, SARA, T. E. Smithgall, Poe, JA, Frasson Ilaria, Poe Jerrod A., Palù, Giorgio, Smithgall, Thomas E., Sara N Richter, Rosalba Perrone, Nadai, M, Palumbo Manlio, Richter, Sara N., Manlio Palumbo, Richter Sara N., Palù, G, Perrone, R, Richter, SN, Smithgall Thomas E., Palù Giorgio, Thomas E Smithgall, PERRONE, ROSALBA, Frasson, I, Nadai Matteo, FRASSON, ILARIA, PALUMBO, MANLIO, Perrone Rosalba   +36 more
core   +2 more sources

Folie et société(s) au tournant du Moyen Âge et de la Renaissance

Babel: Littératures Plurielles, 2012
Dans le chapitre d’ouverture de son Histoire de la folie, Foucault convoque pêle-mêle différents objets pour faire naître deux idées fortes : l’emblème que constitue la Nef des fous d’une part, et d’autre part le grand partage entre expériences cosmique ...
Christine Bénévent
doaj   +1 more source

S6_Data from Nef et al.

, 2022
S6 Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros".
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef

Cell Reports, 2018
We recently identified the multipass transmembrane protein SERINC5 as an antiviral protein that can potently inhibit HIV-1 infectivity and is counteracted by HIV-1 Nef.
Weiwei Dai, Yoshiko Usami, Yuanfei Wu, Heinrich Göttlinger   +3 more
doaj   +1 more source

AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4

mBio, 2023
Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of progeny virions ...
Balaji Olety, Yoshiko Usami, Yuanfei Wu, Paul Peters, Heinrich Göttlinger   +4 more
doaj   +1 more source

Strictly nef divisors [PDF]

Mathematische Annalen, 2008
Let $X$ be a projective manifold of dimension $n$ and $L$ a strictly nef line bundle on $X$. Then $K_X+tL$ is ample if $t > n+1$ in the following cases. 1.) $\text{dim} X = 3$ unless (possibly) $X$ is a Calabi-Yau with $c_2 \cdot L=0$; 2.) $κ(X) \ge n-2$; 3.) $\text{dim} α(X) \ge n-2$, with $α: X \to A$ the Albanese map.
Campana, F., Chen, J.A., Peternell, T.
openaire   +4 more sources

S10_S17_Data from Nef et al.

, 2022
Supplementary Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros". S10 Data.
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source