Results 41 to 50 of about 1,307 (146)
Nef‘î’nin Şiirinde Siyaset Düşüncesi ve Memduhun İstidadı Olarak Cevher
Turcology ResearchCevher Antik Yunan döneminden bu yana felsefenin konusu olmuştur. Aristoteles’in Kategoriler’de etraflıca belirttiği fikirleri cevherin asla bir mevzuda bulunmaması ilkesine dayanmaktadır. Bütün arazların kendisine yüklendiği temel kategori olan cevherin
Hilal Yiğit
doaj +1 more source
Public Administration and Development, EarlyView.ABSTRACT This study examines the impact of administrative autonomy and the separation of roles in public policy on organizational capacity within hybrid public administration systems, particularly in Colombia. It explores the dynamics between elected officials and civil servants, focusing on how the division of responsibilities and the autonomy granted
Camilo Ignacio González +1 more
wiley +1 more source
Public Administration and Development, EarlyView.ABSTRACT The lack of a common variable for comparison has been a major obstacle to the development of Comparative Public Administration (CPA). State autonomy enables an integrative contextualization approach, allowing both the analysis of contextual individual country experiences and the generation of generalized comparable knowledge.
Wilson Wong
wiley +1 more source
M@GM@L’île évoque de multiples symboles : refuge, prison, paradis ou enfer, représentant la marginalité, l’exil et le désir d’ailleurs. Son étymologie grecque associe l’île (nêsos) au navire (naus), suggérant une terre flottante, entre immobilité et mobilité.
Nitouche Anthoussi
doaj +1 more source
HIV-1 Nef inhibits Protease activity and its absence alters protein content of mature viral particles. [PDF]
PLoS ONE, 2014 Nef is an important player for viral infectivity and AIDS progression, but the mechanisms involved are not completely understood. It was previously demonstrated that Nef interacts with GagPol through p6*-Protease region.
Luiza M Mendonça +4 more
doaj +1 more source
The role of iron in normal and impaired testicular function
Andrology, EarlyView.Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer +2 more
wiley +1 more source
Financial Accountability &Management, EarlyView.ABSTRACT Increasingly, community‐based organizations (CBOs) that have a social impact are required to evidence their impact through accountability and evaluation methods that are complex and inappropriate for their specific context. In response to this challenge, we offer a participatory approach to social return on investment (SROI), which builds on a
Rebecca Warren +2 more
wiley +1 more source
The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle
The FEBS Journal, EarlyView.DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh +2 more
wiley +1 more source
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, EarlyView.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source