Results 51 to 60 of about 1,307 (146)
The FEBS Journal, EarlyView.Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff +2 more
wiley +1 more source
A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression
mSphere, 2016 Extensive genetic diversity is a defining characteristic of human immunodeficiency virus type 1 (HIV-1) and poses a significant barrier to the development of an effective vaccine.
Aaron L. Johnson +6 more
doaj +1 more source
Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells. [PDF]
PLoS ONE, 2012 Nef functions as an immunosuppressive factor critical for HIV-1 replication, survival and development of AIDS following HIV-1 infection. What effects Nef exerts on differentiation and maturation of monocytes towards dendritic cells (DCs) remains greatly ...
Yan Guo +5 more
doaj +1 more source
HIV Medicine, EarlyView.Abstract Background The potent immunogenicity of mRNA vaccination raised concerns about its impact on HIV‐1 viral load (VL) and reservoir size in people with HIV, which could drive vaccine hesitancy. As part of a prospective clinical trial, we investigated whether SARS‐CoV‐2 mRNA vaccination induced changes in VL and reservoir size after a 1‐year three‐
Oscar Kieri +8 more
wiley +1 more source
Biology Direct, 2021 Background A variety of hematopoietic abnormalities are commonly seen in human immunodeficiency virus-1 (HIV-1) infected individuals despite antiviral therapy, but the underlying mechanism remains elusive.
Wei Zou +8 more
doaj +1 more source
Journal of Fish Biology, EarlyView.Abstract Marine fish species are likely to exhibit little genetic differentiation among populations due to their high dispersal potential during early life stages and migratory nature. However, recent studies have increasingly reported intraspecific genetic differentiation resulting from species‐specific ecological traits, environmental factors, and ...
Yuki Yamamoto +7 more
wiley +1 more source
PLoS Pathogens, 2013 Nef is the viral gene product employed by the majority of primate lentiviruses to overcome restriction by tetherin (BST-2 or CD317), an interferon-inducible transmembrane protein that inhibits the detachment of enveloped viruses from infected cells ...
Ruth Serra-Moreno +3 more
doaj +1 more source
Determinants of Sustainable Finance Flows: A Literature Review
Journal of Economic Surveys, EarlyView.ABSTRACT Sustainable finance is defined as capital mobilized that explicitly integrate environmental, social, and governance (ESG) objectives alongside traditional financial metrics. It differs from conventional finance in their dual pursuit of financial and sustainability outcomes.
Akin A. Cilekoglu, Fatih Yilmaz
wiley +1 more source
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Little is known about the correlation between subjective perception and objective measures of sleep quality in particular in the oldest‐old. The aim of this study was to perform longitudinal home sleep monitoring in this age group, and to correlate results with self‐reported sleep quality.
Hugo Saner +4 more
wiley +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang +10 more
wiley +1 more source