Results 31 to 40 of about 39,677 (245)

HIV-1 Nef: at the crossroads [PDF]

Retrovirology, 2008
The development of anti-virals has blunted the AIDS epidemic in the Western world but globally the epidemic has not been curtailed. Standard vaccines have not worked, and attenuated vaccines are not being developed because of safety concerns. Interest in attenuated vaccines has centered on isolated cases of patients infected with HIV-1 containing a ...
Garcia J Victor, Foster John L
openaire   +3 more sources

Construction of a Prokaryotic Expression Vector harboring Two HIV-1 Accessory Genes

Medical Laboratory Journal, 2021
Background and objectives: HIV-1 Nef and Vpr antigens have been described as suitable candidates for therapeutic HIV vaccine development. The aim of this study was to generate Nef-Vpr fusion gene construct and to clone the construct into pET-23a (+), a ...
Arash Nikyar, Azam Bolhassani, Fatemeh Rouhollah, Masoumeh Heshmati   +3 more
doaj  

Genetic defects in the nef gene are associated with Korean Red Ginseng intake: monitoring of nef sequence polymorphisms over 20 years

Journal of Ginseng Research, 2017
Background: The presence of gross deletions in the human immunodeficiency virus nef gene (gΔnef) is associated with long-term nonprogression of infected patients.
Young-Keol Cho, Jung-Eun Kim, Jun-Hee Woo   +2 more
doaj   +1 more source

HIV-1 Nef Disrupts CD4 T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface. [PDF]

, 2018
HIV-1 Nef is a multifunctional protein that optimizes virus spread and promotes immune evasion of infected cells to accelerate disease progression in AIDS patients.
Thoma, Judith, Reif, Tatjana, Tsopoulidis, Nikolaos, Trautz, Birthe, Cui, Guoliang, Arora, Sakshi, Wu, Jingxia, Kaw, Sheetal, Ambiel, Ina, Imle, Andrea, Lamas-Murua, Miguel, Stolp, Bettina, Tanaka, Motomu, Lyck, Ruth, Fackler, Oliver T, Tibroni, Nadine, Stein, Jens Volker   +16 more
core   +1 more source

Nef HIV-1 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1), multifunctional protein: features of genetic virus variants circulating in Russia

Вопросы вирусологии
Introduction. Nef provides high level of HIV-1 replication due to synergy of its multiple functions and is an important factor in the pathogenesis of HIV infection. Nef is considered as a target for development of therapeutic agents.
Anna I. Kuznetsova, Anastasiia A. Antonova, Larisa A. Protasova, Anna V. Glyakina, Kristina V. Kim, Iana M. Munchak, Ekaterina N. Mezhenskaya, Elena A. Orlova-Morozova, Alexander Yu. Pronin, Alexey G. Prilipov, Oxana V. Galzitskaya   +10 more
doaj   +1 more source

Karl Nef und die SMG

, 2023
1899 gründete Karl Nef die Ortsgruppe Basel der Internationalen Gesellschaft für Musik. Nach der einseitigen Auflösung der I.G.M. durch den deutschen Landesverein, wurde die Ortsgruppe Basel zum einem Rückzugsort für die Vernetzung von ...
Urchueguía, Cristina
core   +1 more source

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. [PDF]

PLoS ONE, 2018
The HIV-1 Nef accessory protein is essential for viral pathogenicity and AIDS progression. Nef forms complexes with multiple host cell factors to facilitate viral replication and promote immune escape of HIV-infected cells.
Mousheng Wu, John J Alvarado, Corinne E Augelli-Szafran, Roger G Ptak, Thomas E Smithgall   +4 more
doaj   +1 more source

Nef-containing exosomes deliver Nef to macrophages.

, 2019
A—Size distribution of the extracellular vesicles secreted by HEK293 cells determined by EM; Inset–EM micrograph of the vesicles; bar– 200 nm. B—Western blot for the exosomal marker Alix and Nef in cells and exosomes (exNef); C—Western blot for the ...
Ryunosuke Ohkawa (514009), Andrew Murphy (341397), Hann Low (6612692), Peter J. Meikle (54253), Dmitri Sviridov (54259), Michael Ditiatkovski (432029), Yury I. Miller (181644), Ying Fu (173963), Nigora Mukhamedova (54252), Tatiana Pushkarsky (363651), Michael Bukrinsky (45092), Beda Brichacek (361586), Dragana Dragoljevic (7042715), Larisa Dubrovsky (45091), Anelia Horvath (444445), Anh Hoang (6612695)   +15 more
core   +1 more source

Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses [PDF]

, 2010
Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1
McKinnon, E., Rebecca Laird, Chopra, A., John, M., Simon Mallal, Almeida, C.M., Keane, N.M., Abha Chopra, David Heckerman, Heckerman, D., Imran Ahmad, Coral-Ann M. Almeida, Elizabeth McKinnon, Carl Kadie, Roberts, S.G., Mina John, Kadie, C., Niamh M. Keane, Laird, R., Steven G. Roberts, Ahmad, I., Mallal, S.   +21 more
core   +1 more source

The end of Nef's tether [PDF]

Trends in Microbiology, 2014
Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa.
openaire   +2 more sources